Metabolism of dynorphin A1-13 in human CSF

In-vitro incubation of human cerebrospinal fluid (CSF) obtained from patients ranging from 22-78 years with 10 microM of dynorphin A1-13 (Dyn A1-13) resulted in several cleavage products. Dyn A1-12 and A2-13 were identified as the major CSF metabolites by matrix-assisted laser desorption mass spectr...

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Veröffentlicht in:	Neurochemical research 1996-10, Vol.21 (10), p.1213-1219
Hauptverfasser:	MÜLLER, S, GRUNDY, B. L, HOCHHAUS, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aging - cerebrospinal fluid Aminopeptidases - antagonists & inhibitors Aminopeptidases - metabolism Biological and medical sciences Carboxypeptidases - antagonists & inhibitors Carboxypeptidases - metabolism Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Chromatography, High Pressure Liquid Dynorphins - blood Dynorphins - cerebrospinal fluid Enzyme Inhibitors - pharmacology Female Fundamental and applied biological sciences. Psychology Half-Life Humans Male Mass Spectrometry Middle Aged Peptide Fragments - blood Peptide Fragments - cerebrospinal fluid Vertebrates: nervous system and sense organs
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