SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS IN THE CEFPIROME SERIES: III. 7α-METHOXY AND 7α-FORMAMIDO ANALOGUES OF CEFPIROME

7α-Methoxy and 7α-formamido derivatives of cefpirome (HR 810) have been synthesized and tested in comparison with cefpirome and some analogues 1 against aerobic and anaerobic bacteria. Cefpirome and analogues 1 have good activity against Gram-positive and only limited activity against Gram-negative...

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Veröffentlicht in:	Journal of antibiotics 1988/10/25, Vol.41(10), pp.1409-1417
Hauptverfasser:	LATTRELL, RUDOLF, DUERCKHEIMER, WALTER, LIMBERT, MICHAEL
Format:	Artikel
Sprache:	eng
Schlagworte:	Cefpirome Cephalosporins - chemical synthesis Cephalosporins - pharmacology Chemical Phenomena Chemistry Exact sciences and technology Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Magnetic Resonance Spectroscopy Organic chemistry Preparations and properties Structure-Activity Relationship
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