Transforming growth factor-beta 2 down-regulates HLA-DR antigen expression on human malignant glioma cells

Transforming growth factor-beta (TGF-beta) is known to have a potent inhibitory influence on several immune functions. It has recently been demonstrated that TGF-beta 2 is identical to the glioblastoma-derived T cell suppressor factor (G-TsF). In the present study, human malignant glioma cell lines...

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Veröffentlicht in:	European journal of immunology 1988-10, Vol.18 (10), p.1623-1626
Hauptverfasser:	Zuber, P, Kuppner, M C, De Tribolet, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology beta 2-Microglobulin - immunology Blotting, Northern Flow Cytometry Glioma - immunology HLA Antigens - immunology HLA-DR Antigens - genetics HLA-DR Antigens - immunology Humans Interferon-gamma - pharmacology Recombinant Proteins RNA, Messenger - genetics Transforming Growth Factors - pharmacology Tumor Cells, Cultured
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