Occult Blood Versus Fecal Leukocytes in the Diagnosis of Bacterial Diarrhea: a Study of U.S. Travelers to Mexico and Mexican Children
A study was done to test the effectiveness of fecal occult blood as a screening test for invasive bacterial pathogens and as a substitute for the fecal leukocyte examination in adult and pediatric cases of acute diarrhea. United States citizens studying in Mexico and Mexican children, both with acut...
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Veröffentlicht in: | The American journal of tropical medicine and hygiene 1996-10, Vol.55 (4), p.430-433 |
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creator | McNeely, Wesley S Dupont, Herbert L Mathewson, John J Oberhelman, Richard A Ericsson, Charles D |
description | A study was done to test the effectiveness of fecal occult blood as a screening test for invasive bacterial pathogens and as a substitute for the fecal leukocyte examination in adult and pediatric cases of acute diarrhea. United States citizens studying in Mexico and Mexican children, both with acute diarrhea had their stools cultured, examined for fecal leukocytes, and tested for occult blood. Using culture results as the criterion standard for detection of bacterial agents, and fecal leukocytes for diarrhea associated with diffuse colonic inflammation, occult blood was tested for its sensitivity, specificity, and predictive value using 2 x 2 tables. Analysis of the data found that occult blood negative samples were reliable indicators of a lack of invasive bacteria in both adult and pediatric patients (negative predictive values of 87% and 96%, respectively). Positive results for either test were not reliably predictive as indicators of invasive bacteria among adults. A positive occult blood test result was significantly more sensitive than a positive fecal leukocyte test result (79% versus 42%) in detecting invasive bacteria in the pediatric patients; however, the positive predictive value was only 24%. The fecal occult blood test is an uncomplicated, low-cost test that was reliable when giving a negative result in detecting a lack of invasive bacteria in adult and pediatric patients with diarrhea. In children, a positive result on a fecal occult blood test is sensitive but not specific in detecting invasive bacterial enteropathogens. These data also indicate that a commercially available test for occult blood represents a suitable alternative to microscopic examination of fecal samples for leukocytes obtained from patients with acute diarrhea. |
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United States citizens studying in Mexico and Mexican children, both with acute diarrhea had their stools cultured, examined for fecal leukocytes, and tested for occult blood. Using culture results as the criterion standard for detection of bacterial agents, and fecal leukocytes for diarrhea associated with diffuse colonic inflammation, occult blood was tested for its sensitivity, specificity, and predictive value using 2 x 2 tables. Analysis of the data found that occult blood negative samples were reliable indicators of a lack of invasive bacteria in both adult and pediatric patients (negative predictive values of 87% and 96%, respectively). Positive results for either test were not reliably predictive as indicators of invasive bacteria among adults. A positive occult blood test result was significantly more sensitive than a positive fecal leukocyte test result (79% versus 42%) in detecting invasive bacteria in the pediatric patients; however, the positive predictive value was only 24%. The fecal occult blood test is an uncomplicated, low-cost test that was reliable when giving a negative result in detecting a lack of invasive bacteria in adult and pediatric patients with diarrhea. In children, a positive result on a fecal occult blood test is sensitive but not specific in detecting invasive bacterial enteropathogens. These data also indicate that a commercially available test for occult blood represents a suitable alternative to microscopic examination of fecal samples for leukocytes obtained from patients with acute diarrhea.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.1996.55.430</identifier><identifier>PMID: 8916801</identifier><identifier>CODEN: AJTHAB</identifier><language>eng</language><publisher>Lawrence, KS: ASTMH</publisher><subject>Acute Disease ; Adult ; Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Bacterial Infections - diagnosis ; Biological and medical sciences ; Child ; Child, Preschool ; Diarrhea - diagnosis ; Diarrhea, Infantile - diagnosis ; Feces - cytology ; Human bacterial diseases ; Humans ; Infant ; Infectious diseases ; Leukocytes ; Medical sciences ; Mexico ; Occult Blood ; Predictive Value of Tests ; Sensitivity and Specificity ; Travel ; Tropical medicine ; United States</subject><ispartof>The American journal of tropical medicine and hygiene, 1996-10, Vol.55 (4), p.430-433</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-1afd853c109258c7fc04d407cade408b670f2f793fe1d9b47d66ba65472d1f4e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2488446$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8916801$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McNeely, Wesley S</creatorcontrib><creatorcontrib>Dupont, Herbert L</creatorcontrib><creatorcontrib>Mathewson, John J</creatorcontrib><creatorcontrib>Oberhelman, Richard A</creatorcontrib><creatorcontrib>Ericsson, Charles D</creatorcontrib><title>Occult Blood Versus Fecal Leukocytes in the Diagnosis of Bacterial Diarrhea: a Study of U.S. Travelers to Mexico and Mexican Children</title><title>The American journal of tropical medicine and hygiene</title><addtitle>Am J Trop Med Hyg</addtitle><description>A study was done to test the effectiveness of fecal occult blood as a screening test for invasive bacterial pathogens and as a substitute for the fecal leukocyte examination in adult and pediatric cases of acute diarrhea. United States citizens studying in Mexico and Mexican children, both with acute diarrhea had their stools cultured, examined for fecal leukocytes, and tested for occult blood. Using culture results as the criterion standard for detection of bacterial agents, and fecal leukocytes for diarrhea associated with diffuse colonic inflammation, occult blood was tested for its sensitivity, specificity, and predictive value using 2 x 2 tables. Analysis of the data found that occult blood negative samples were reliable indicators of a lack of invasive bacteria in both adult and pediatric patients (negative predictive values of 87% and 96%, respectively). Positive results for either test were not reliably predictive as indicators of invasive bacteria among adults. A positive occult blood test result was significantly more sensitive than a positive fecal leukocyte test result (79% versus 42%) in detecting invasive bacteria in the pediatric patients; however, the positive predictive value was only 24%. The fecal occult blood test is an uncomplicated, low-cost test that was reliable when giving a negative result in detecting a lack of invasive bacteria in adult and pediatric patients with diarrhea. In children, a positive result on a fecal occult blood test is sensitive but not specific in detecting invasive bacterial enteropathogens. These data also indicate that a commercially available test for occult blood represents a suitable alternative to microscopic examination of fecal samples for leukocytes obtained from patients with acute diarrhea.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Bacterial Infections - diagnosis</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diarrhea - diagnosis</subject><subject>Diarrhea, Infantile - diagnosis</subject><subject>Feces - cytology</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Leukocytes</subject><subject>Medical sciences</subject><subject>Mexico</subject><subject>Occult Blood</subject><subject>Predictive Value of Tests</subject><subject>Sensitivity and Specificity</subject><subject>Travel</subject><subject>Tropical medicine</subject><subject>United States</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAURi0EKkPhAVggeQHsEuzEPwk7OlBAGtRFW7aWx75uXDxxaycM8wC8N57OqFtWtvyd-13JB6HXlNSsEf0HfTtthpr2vag5r1lLnqAFZVJUVDD-FC0IIU3Vi1Y-Ry9yviWEdg2lJ-ik66noCF2gvxfGzGHCZyFGi39CynPG52B0wCuYf0WzmyBjP-JpAPzZ65sxZp9xdPhMmwmSL2B5TmkA_RFrfDnNdrePr-vLGl8l_RtCKcVTxD_gjzcR69EernrEy8EHm2B8iZ45HTK8Op6n6Pr8y9XyW7W6-Pp9-WlVmbYTU0W1sx1vDSV9wzsjnSHMMiKNtsBItxaSuMbJvnVAbb9m0gqx1oIz2VjqGLSn6P2h9y7F-xnypDY-GwhBjxDnrGRpl7SV_wUpLx9IG15AegBNijkncOou-Y1OO0WJ2jtSD47U3pHiXBVHZebNsXxeb8A-ThyllPztMde5iHBJj8bnR6xhXceYKNi7Azb4m2HrE6i80SGUUqq22-1-2cO6f5wYp8w</recordid><startdate>19961001</startdate><enddate>19961001</enddate><creator>McNeely, Wesley S</creator><creator>Dupont, Herbert L</creator><creator>Mathewson, John J</creator><creator>Oberhelman, Richard A</creator><creator>Ericsson, Charles D</creator><general>ASTMH</general><general>Allen Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19961001</creationdate><title>Occult Blood Versus Fecal Leukocytes in the Diagnosis of Bacterial Diarrhea: a Study of U.S. Travelers to Mexico and Mexican Children</title><author>McNeely, Wesley S ; Dupont, Herbert L ; Mathewson, John J ; Oberhelman, Richard A ; Ericsson, Charles D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-1afd853c109258c7fc04d407cade408b670f2f793fe1d9b47d66ba65472d1f4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Acute Disease</topic><topic>Adult</topic><topic>Bacterial diseases</topic><topic>Bacterial diseases of the digestive system and abdomen</topic><topic>Bacterial Infections - diagnosis</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diarrhea - diagnosis</topic><topic>Diarrhea, Infantile - diagnosis</topic><topic>Feces - cytology</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Leukocytes</topic><topic>Medical sciences</topic><topic>Mexico</topic><topic>Occult Blood</topic><topic>Predictive Value of Tests</topic><topic>Sensitivity and Specificity</topic><topic>Travel</topic><topic>Tropical medicine</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McNeely, Wesley S</creatorcontrib><creatorcontrib>Dupont, Herbert L</creatorcontrib><creatorcontrib>Mathewson, John J</creatorcontrib><creatorcontrib>Oberhelman, Richard A</creatorcontrib><creatorcontrib>Ericsson, Charles D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McNeely, Wesley S</au><au>Dupont, Herbert L</au><au>Mathewson, John J</au><au>Oberhelman, Richard A</au><au>Ericsson, Charles D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Occult Blood Versus Fecal Leukocytes in the Diagnosis of Bacterial Diarrhea: a Study of U.S. Travelers to Mexico and Mexican Children</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>1996-10-01</date><risdate>1996</risdate><volume>55</volume><issue>4</issue><spage>430</spage><epage>433</epage><pages>430-433</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><coden>AJTHAB</coden><abstract>A study was done to test the effectiveness of fecal occult blood as a screening test for invasive bacterial pathogens and as a substitute for the fecal leukocyte examination in adult and pediatric cases of acute diarrhea. United States citizens studying in Mexico and Mexican children, both with acute diarrhea had their stools cultured, examined for fecal leukocytes, and tested for occult blood. Using culture results as the criterion standard for detection of bacterial agents, and fecal leukocytes for diarrhea associated with diffuse colonic inflammation, occult blood was tested for its sensitivity, specificity, and predictive value using 2 x 2 tables. Analysis of the data found that occult blood negative samples were reliable indicators of a lack of invasive bacteria in both adult and pediatric patients (negative predictive values of 87% and 96%, respectively). Positive results for either test were not reliably predictive as indicators of invasive bacteria among adults. A positive occult blood test result was significantly more sensitive than a positive fecal leukocyte test result (79% versus 42%) in detecting invasive bacteria in the pediatric patients; however, the positive predictive value was only 24%. The fecal occult blood test is an uncomplicated, low-cost test that was reliable when giving a negative result in detecting a lack of invasive bacteria in adult and pediatric patients with diarrhea. In children, a positive result on a fecal occult blood test is sensitive but not specific in detecting invasive bacterial enteropathogens. These data also indicate that a commercially available test for occult blood represents a suitable alternative to microscopic examination of fecal samples for leukocytes obtained from patients with acute diarrhea.</abstract><cop>Lawrence, KS</cop><pub>ASTMH</pub><pmid>8916801</pmid><doi>10.4269/ajtmh.1996.55.430</doi><tpages>4</tpages></addata></record> |
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subjects | Acute Disease Adult Bacterial diseases Bacterial diseases of the digestive system and abdomen Bacterial Infections - diagnosis Biological and medical sciences Child Child, Preschool Diarrhea - diagnosis Diarrhea, Infantile - diagnosis Feces - cytology Human bacterial diseases Humans Infant Infectious diseases Leukocytes Medical sciences Mexico Occult Blood Predictive Value of Tests Sensitivity and Specificity Travel Tropical medicine United States |
title | Occult Blood Versus Fecal Leukocytes in the Diagnosis of Bacterial Diarrhea: a Study of U.S. Travelers to Mexico and Mexican Children |
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