Metabolic Fate of Iodine-123-BMIPP in Canine Myocardium after Administration of Etomoxir
To clarify the metabolic fate of 123I-(-p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) in dysfunctional myocardium, a comparison between normal dogs and those with etomoxir administration was studied using an open-chest canine model. Using open-chested dogs under anesthesia, we created a syste...
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Veröffentlicht in: | The Journal of nuclear medicine (1978) 1996-11, Vol.37 (11), p.1836-1840 |
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container_title | The Journal of nuclear medicine (1978) |
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creator | Hosokawa, Ryohei Nohara, Ryuji Fujibayashi, Yasuhisa Okuda, Kazumi Ogino, Motonari Hata, Tatsuhiko Fujita, Masatoshi Tamaki, Nagara Konishi, Junji Sasayama, Shigetake |
description | To clarify the metabolic fate of 123I-(-p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) in dysfunctional myocardium, a comparison between normal dogs and those with etomoxir administration was studied using an open-chest canine model.
Using open-chested dogs under anesthesia, we created a system to release all the blood in the great cardiac vein outside without recirculation, if necessary. Iodine-123-BMIPP was directly injected into the left anterior descending artery, its extraction, retention and washout rate in the early phase were calculated, and the metabolites in the myocardium were evaluated using a high-performance liquid chromatography. Moreover, these factors were compared between normal dogs and those pretreated with etomoxir, that creates a condition similar to ischemia.
Although rapid extraction of BMIPP from the plasma into the myocardium and the subsequent retention were unchanged, early washout (8 min) of radioactivity significantly increased (49.6% +/- 13.3%-->70.5% +/- 10.7%, p < 0.05) with etomoxir. The levels of the full metabolite formed by complete oxidation of BMIPP decreased significantly with etomoxir (21.4% +/- 10.9%-->5.5% +/- 3.5%, p < 0.01). In addition, back diffusion of BMIPP increased (25.1% +/- 8.0%-->41.9% +/- 12.0%, p < 0.05) in the etomoxir-treated animals without affecting the levels of alpha-oxidation metabolite and the intermediate metabolites.
BMIPP is very sensitive to etomoxir and is suitable for assessing mitochondrial dysfunction. Iodine-123-BMIPP might be a promising radiopharmaceutical for the evaluation of ischemic heart disease, cardiomyopathy and mitochondrial encephalomyopathy. |
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Using open-chested dogs under anesthesia, we created a system to release all the blood in the great cardiac vein outside without recirculation, if necessary. Iodine-123-BMIPP was directly injected into the left anterior descending artery, its extraction, retention and washout rate in the early phase were calculated, and the metabolites in the myocardium were evaluated using a high-performance liquid chromatography. Moreover, these factors were compared between normal dogs and those pretreated with etomoxir, that creates a condition similar to ischemia.
Although rapid extraction of BMIPP from the plasma into the myocardium and the subsequent retention were unchanged, early washout (8 min) of radioactivity significantly increased (49.6% +/- 13.3%-->70.5% +/- 10.7%, p < 0.05) with etomoxir. The levels of the full metabolite formed by complete oxidation of BMIPP decreased significantly with etomoxir (21.4% +/- 10.9%-->5.5% +/- 3.5%, p < 0.01). In addition, back diffusion of BMIPP increased (25.1% +/- 8.0%-->41.9% +/- 12.0%, p < 0.05) in the etomoxir-treated animals without affecting the levels of alpha-oxidation metabolite and the intermediate metabolites.
BMIPP is very sensitive to etomoxir and is suitable for assessing mitochondrial dysfunction. Iodine-123-BMIPP might be a promising radiopharmaceutical for the evaluation of ischemic heart disease, cardiomyopathy and mitochondrial encephalomyopathy.</description><identifier>ISSN: 0161-5505</identifier><identifier>EISSN: 1535-5667</identifier><identifier>PMID: 8917188</identifier><identifier>CODEN: JNMEAQ</identifier><language>eng</language><publisher>Reston, VA: Soc Nuclear Med</publisher><subject>Animals ; Biological and medical sciences ; Cardiovascular system ; Chromatography, High Pressure Liquid ; Coronary Circulation - drug effects ; Dogs ; Epoxy Compounds - pharmacology ; Fatty Acids - metabolism ; Heart - diagnostic imaging ; Heart - drug effects ; Investigative techniques, diagnostic techniques (general aspects) ; Iodine Radioisotopes ; Iodobenzenes - metabolism ; Medical sciences ; Myocardial Ischemia - diagnostic imaging ; Myocardium - metabolism ; Radionuclide Imaging ; Radionuclide investigations</subject><ispartof>The Journal of nuclear medicine (1978), 1996-11, Vol.37 (11), p.1836-1840</ispartof><rights>1997 INIST-CNRS</rights><rights>Copyright Society of Nuclear Medicine Nov 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2488676$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8917188$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hosokawa, Ryohei</creatorcontrib><creatorcontrib>Nohara, Ryuji</creatorcontrib><creatorcontrib>Fujibayashi, Yasuhisa</creatorcontrib><creatorcontrib>Okuda, Kazumi</creatorcontrib><creatorcontrib>Ogino, Motonari</creatorcontrib><creatorcontrib>Hata, Tatsuhiko</creatorcontrib><creatorcontrib>Fujita, Masatoshi</creatorcontrib><creatorcontrib>Tamaki, Nagara</creatorcontrib><creatorcontrib>Konishi, Junji</creatorcontrib><creatorcontrib>Sasayama, Shigetake</creatorcontrib><title>Metabolic Fate of Iodine-123-BMIPP in Canine Myocardium after Administration of Etomoxir</title><title>The Journal of nuclear medicine (1978)</title><addtitle>J Nucl Med</addtitle><description>To clarify the metabolic fate of 123I-(-p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) in dysfunctional myocardium, a comparison between normal dogs and those with etomoxir administration was studied using an open-chest canine model.
Using open-chested dogs under anesthesia, we created a system to release all the blood in the great cardiac vein outside without recirculation, if necessary. Iodine-123-BMIPP was directly injected into the left anterior descending artery, its extraction, retention and washout rate in the early phase were calculated, and the metabolites in the myocardium were evaluated using a high-performance liquid chromatography. Moreover, these factors were compared between normal dogs and those pretreated with etomoxir, that creates a condition similar to ischemia.
Although rapid extraction of BMIPP from the plasma into the myocardium and the subsequent retention were unchanged, early washout (8 min) of radioactivity significantly increased (49.6% +/- 13.3%-->70.5% +/- 10.7%, p < 0.05) with etomoxir. The levels of the full metabolite formed by complete oxidation of BMIPP decreased significantly with etomoxir (21.4% +/- 10.9%-->5.5% +/- 3.5%, p < 0.01). In addition, back diffusion of BMIPP increased (25.1% +/- 8.0%-->41.9% +/- 12.0%, p < 0.05) in the etomoxir-treated animals without affecting the levels of alpha-oxidation metabolite and the intermediate metabolites.
BMIPP is very sensitive to etomoxir and is suitable for assessing mitochondrial dysfunction. Iodine-123-BMIPP might be a promising radiopharmaceutical for the evaluation of ischemic heart disease, cardiomyopathy and mitochondrial encephalomyopathy.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Coronary Circulation - drug effects</subject><subject>Dogs</subject><subject>Epoxy Compounds - pharmacology</subject><subject>Fatty Acids - metabolism</subject><subject>Heart - diagnostic imaging</subject><subject>Heart - drug effects</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Iodine Radioisotopes</subject><subject>Iodobenzenes - metabolism</subject><subject>Medical sciences</subject><subject>Myocardial Ischemia - diagnostic imaging</subject><subject>Myocardium - metabolism</subject><subject>Radionuclide Imaging</subject><subject>Radionuclide investigations</subject><issn>0161-5505</issn><issn>1535-5667</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpd0FFLwzAQB_AiypzTjyAEEfGlkEuWNHmcY9PBhntQ8K2kbeIy2mQmLbpvb8eGDz4d3P3-x3FnyRAYZSnjPDtPhhg4pIxhdplcxbjFGHMhxCAZCAkZCDFMPla6VYWvbYnmqtXIG7TwlXU6BULTp9VivUbWoalyfQ-t9r5UobJdg5RpdUCTqrHOxjao1np3SM9a3_gfG66TC6PqqG9OdZS8z2dv05d0-fq8mE6W6YbIrE05l5pLKjUpGKZVIWhppGKsUNgUWhlBMZixAJBCE13BuDSmAlrhPiUxFHSUPBz37oL_6nRs88bGUte1ctp3Mc8Eo0QQ6OHdP7j1XXD9bTkBCbJnpEe3J9QVja7yXbCNCvv89K9-fn-aq1iq2gTlShv_GBkLwTPes8cj29jPzbcNOnddWWsVDju3rqFZDpCDoJz-AkNugIs</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>Hosokawa, Ryohei</creator><creator>Nohara, Ryuji</creator><creator>Fujibayashi, Yasuhisa</creator><creator>Okuda, Kazumi</creator><creator>Ogino, Motonari</creator><creator>Hata, Tatsuhiko</creator><creator>Fujita, Masatoshi</creator><creator>Tamaki, Nagara</creator><creator>Konishi, Junji</creator><creator>Sasayama, Shigetake</creator><general>Soc Nuclear Med</general><general>Society of Nuclear Medicine</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>4T-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>M7Z</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>19961101</creationdate><title>Metabolic Fate of Iodine-123-BMIPP in Canine Myocardium after Administration of Etomoxir</title><author>Hosokawa, Ryohei ; Nohara, Ryuji ; Fujibayashi, Yasuhisa ; Okuda, Kazumi ; Ogino, Motonari ; Hata, Tatsuhiko ; Fujita, Masatoshi ; Tamaki, Nagara ; Konishi, Junji ; Sasayama, Shigetake</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h297t-669e6939e2b503db83cf9a55ba0fbeaf8301f481198e2ed14cffd13d0e69901b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Coronary Circulation - drug effects</topic><topic>Dogs</topic><topic>Epoxy Compounds - pharmacology</topic><topic>Fatty Acids - metabolism</topic><topic>Heart - diagnostic imaging</topic><topic>Heart - drug effects</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Iodine Radioisotopes</topic><topic>Iodobenzenes - metabolism</topic><topic>Medical sciences</topic><topic>Myocardial Ischemia - diagnostic imaging</topic><topic>Myocardium - metabolism</topic><topic>Radionuclide Imaging</topic><topic>Radionuclide investigations</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hosokawa, Ryohei</creatorcontrib><creatorcontrib>Nohara, Ryuji</creatorcontrib><creatorcontrib>Fujibayashi, Yasuhisa</creatorcontrib><creatorcontrib>Okuda, Kazumi</creatorcontrib><creatorcontrib>Ogino, Motonari</creatorcontrib><creatorcontrib>Hata, Tatsuhiko</creatorcontrib><creatorcontrib>Fujita, Masatoshi</creatorcontrib><creatorcontrib>Tamaki, Nagara</creatorcontrib><creatorcontrib>Konishi, Junji</creatorcontrib><creatorcontrib>Sasayama, Shigetake</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nuclear medicine (1978)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hosokawa, Ryohei</au><au>Nohara, Ryuji</au><au>Fujibayashi, Yasuhisa</au><au>Okuda, Kazumi</au><au>Ogino, Motonari</au><au>Hata, Tatsuhiko</au><au>Fujita, Masatoshi</au><au>Tamaki, Nagara</au><au>Konishi, Junji</au><au>Sasayama, Shigetake</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic Fate of Iodine-123-BMIPP in Canine Myocardium after Administration of Etomoxir</atitle><jtitle>The Journal of nuclear medicine (1978)</jtitle><addtitle>J Nucl Med</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>37</volume><issue>11</issue><spage>1836</spage><epage>1840</epage><pages>1836-1840</pages><issn>0161-5505</issn><eissn>1535-5667</eissn><coden>JNMEAQ</coden><abstract>To clarify the metabolic fate of 123I-(-p-iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP) in dysfunctional myocardium, a comparison between normal dogs and those with etomoxir administration was studied using an open-chest canine model.
Using open-chested dogs under anesthesia, we created a system to release all the blood in the great cardiac vein outside without recirculation, if necessary. Iodine-123-BMIPP was directly injected into the left anterior descending artery, its extraction, retention and washout rate in the early phase were calculated, and the metabolites in the myocardium were evaluated using a high-performance liquid chromatography. Moreover, these factors were compared between normal dogs and those pretreated with etomoxir, that creates a condition similar to ischemia.
Although rapid extraction of BMIPP from the plasma into the myocardium and the subsequent retention were unchanged, early washout (8 min) of radioactivity significantly increased (49.6% +/- 13.3%-->70.5% +/- 10.7%, p < 0.05) with etomoxir. The levels of the full metabolite formed by complete oxidation of BMIPP decreased significantly with etomoxir (21.4% +/- 10.9%-->5.5% +/- 3.5%, p < 0.01). In addition, back diffusion of BMIPP increased (25.1% +/- 8.0%-->41.9% +/- 12.0%, p < 0.05) in the etomoxir-treated animals without affecting the levels of alpha-oxidation metabolite and the intermediate metabolites.
BMIPP is very sensitive to etomoxir and is suitable for assessing mitochondrial dysfunction. Iodine-123-BMIPP might be a promising radiopharmaceutical for the evaluation of ischemic heart disease, cardiomyopathy and mitochondrial encephalomyopathy.</abstract><cop>Reston, VA</cop><pub>Soc Nuclear Med</pub><pmid>8917188</pmid><tpages>5</tpages></addata></record> |
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subjects | Animals Biological and medical sciences Cardiovascular system Chromatography, High Pressure Liquid Coronary Circulation - drug effects Dogs Epoxy Compounds - pharmacology Fatty Acids - metabolism Heart - diagnostic imaging Heart - drug effects Investigative techniques, diagnostic techniques (general aspects) Iodine Radioisotopes Iodobenzenes - metabolism Medical sciences Myocardial Ischemia - diagnostic imaging Myocardium - metabolism Radionuclide Imaging Radionuclide investigations |
title | Metabolic Fate of Iodine-123-BMIPP in Canine Myocardium after Administration of Etomoxir |
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