Refined mapping of 12q13-q15 amplicons in human malignant gliomas suggests CDK4/SAS and MDM2 as independent amplification targets

We have reported previously that about 15% of anaplastic astrocytomas and glioblastomas show amplification and overexpression of one or more genes from chromosomal segment 12q13-q15 (G. Reifenberger et al., Cancer Res., 54, 4299-4303, 1994). The genes most frequently amplified and overexpressed were...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1996-11, Vol.56 (22), p.5141-5145
Hauptverfasser:	REIFENBERGER, G, ICHIMURA, K, REIFENBERGER, J, ELKAHLOUN, A. G, MELTZER, P. S, COLLINS, V. P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Brain Neoplasms - genetics Chromosome Mapping - methods Chromosomes, Human, Pair 12 - genetics Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinases - genetics DNA Probes - genetics Female Gene Amplification - genetics Glioblastoma - genetics Humans Male Medical sciences Middle Aged Molecular Sequence Data Neoplasm Proteins - genetics Neurology Nuclear Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-mdm2 Tumors of the nervous system. Phacomatoses
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