Intraoperative Mitomycin C in the Treatment of Cicatricial Obliterations of Conjunctival Fornices
To investigate whether the intraoperative use of topical mitomycin C improved the postoperative outcome in cases of cicatricial obliteration of conjunctival fornices. Ten eyes of five patients were subjected to surgical lysis of the synechiae followed by intraoperative application of 0.4 mg mitomyci...
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| Veröffentlicht in: | American journal of ophthalmology 1996-11, Vol.122 (5), p.728-730 |
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| container_title | American journal of ophthalmology |
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| creator | Secchi, Antonio G. Tognon, M. Sofia |
| description | To investigate whether the intraoperative use of topical mitomycin C improved the postoperative outcome in cases of cicatricial obliteration of conjunctival fornices.
Ten eyes of five patients were subjected to surgical lysis of the synechiae followed by intraoperative application of 0.4 mg mitomycin C per milliliter of saline for 3 to 5 minutes.
After a follow-up period of 12 to 19 months, no recurrence of synechiae was observed, the conjunctival fornices remained open, and conjunctival overgrowths on the cornea did not recur. No adverse effect was observed.
Intraoperative application of mitomycin C proved useful in the surgical treatment of cicatricial shrinkage of conjunctival fornices. |
| doi_str_mv | 10.1016/S0002-9394(14)70495-7 |
| format | Article |
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Ten eyes of five patients were subjected to surgical lysis of the synechiae followed by intraoperative application of 0.4 mg mitomycin C per milliliter of saline for 3 to 5 minutes.
After a follow-up period of 12 to 19 months, no recurrence of synechiae was observed, the conjunctival fornices remained open, and conjunctival overgrowths on the cornea did not recur. No adverse effect was observed.
Intraoperative application of mitomycin C proved useful in the surgical treatment of cicatricial shrinkage of conjunctival fornices.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/S0002-9394(14)70495-7</identifier><identifier>PMID: 8909216</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Administration, Topical ; Biological and medical sciences ; Conjunctiva - drug effects ; Conjunctiva - surgery ; Conjunctival Diseases - therapy ; Follow-Up Studies ; Humans ; Intraoperative Care ; Medical sciences ; Mitomycin - therapeutic use ; Nucleic Acid Synthesis Inhibitors - therapeutic use ; Ophthalmic Solutions ; Pemphigoid, Benign Mucous Membrane - therapy ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the eye and orbit</subject><ispartof>American journal of ophthalmology, 1996-11, Vol.122 (5), p.728-730</ispartof><rights>1996 Elsevier Inc.</rights><rights>1997 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. Nov 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-b79e700c6526c79b5df971aaa0ef21038640f25e4e8ef52e1060e8bce7a3e7b23</citedby><cites>FETCH-LOGICAL-c416t-b79e700c6526c79b5df971aaa0ef21038640f25e4e8ef52e1060e8bce7a3e7b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002939414704957$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2473979$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8909216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Secchi, Antonio G.</creatorcontrib><creatorcontrib>Tognon, M. Sofia</creatorcontrib><title>Intraoperative Mitomycin C in the Treatment of Cicatricial Obliterations of Conjunctival Fornices</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>To investigate whether the intraoperative use of topical mitomycin C improved the postoperative outcome in cases of cicatricial obliteration of conjunctival fornices.
Ten eyes of five patients were subjected to surgical lysis of the synechiae followed by intraoperative application of 0.4 mg mitomycin C per milliliter of saline for 3 to 5 minutes.
After a follow-up period of 12 to 19 months, no recurrence of synechiae was observed, the conjunctival fornices remained open, and conjunctival overgrowths on the cornea did not recur. No adverse effect was observed.
Intraoperative application of mitomycin C proved useful in the surgical treatment of cicatricial shrinkage of conjunctival fornices.</description><subject>Administration, Topical</subject><subject>Biological and medical sciences</subject><subject>Conjunctiva - drug effects</subject><subject>Conjunctiva - surgery</subject><subject>Conjunctival Diseases - therapy</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Intraoperative Care</subject><subject>Medical sciences</subject><subject>Mitomycin - therapeutic use</subject><subject>Nucleic Acid Synthesis Inhibitors - therapeutic use</subject><subject>Ophthalmic Solutions</subject><subject>Pemphigoid, Benign Mucous Membrane - therapy</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the eye and orbit</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVJSbdJf0LAlBDag5uRLEvWKYSlaQMpOTQ9C1k7plpsaSvJC_n31X6wh1560SDe5x2Gh5ArCl8oUHH7EwBYrRrFP1H-WQJXbS3fkAXtpKppp-gZWZyQd-R9SuvyFZLLc3LeKVCMigUxjz5HEzYYTXZbrH64HKZX63y1rMqTf2P1EtHkCX2uwlAtnTU5OuvMWD33o8v7YvBpHwa_nr0ti0r6EKJ3FtMleTuYMeGH47wgvx6-viy_10_P3x6X90-15VTkupcKJYAVLRNWqr5dDUpSYwzgwCg0neAwsBY5dji0DCkIwK63KE2DsmfNBbk57N3E8GfGlPXkksVxNB7DnLTsWsYohwJ-_Adchzn6cptmTHGQTOyg9gDZGFKKOOhNdJOJr5qC3vnXe_96J1dTrvf-tSy9q-PyuZ9wdWodhZf8-pibZM04ROOtSyeMcdkoqQp2d8CwGNs6jDpZh97iykW0Wa-C-88hfwHNfqHg</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>Secchi, Antonio G.</creator><creator>Tognon, M. Sofia</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19961101</creationdate><title>Intraoperative Mitomycin C in the Treatment of Cicatricial Obliterations of Conjunctival Fornices</title><author>Secchi, Antonio G. ; Tognon, M. Sofia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-b79e700c6526c79b5df971aaa0ef21038640f25e4e8ef52e1060e8bce7a3e7b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Administration, Topical</topic><topic>Biological and medical sciences</topic><topic>Conjunctiva - drug effects</topic><topic>Conjunctiva - surgery</topic><topic>Conjunctival Diseases - therapy</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Intraoperative Care</topic><topic>Medical sciences</topic><topic>Mitomycin - therapeutic use</topic><topic>Nucleic Acid Synthesis Inhibitors - therapeutic use</topic><topic>Ophthalmic Solutions</topic><topic>Pemphigoid, Benign Mucous Membrane - therapy</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the eye and orbit</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Secchi, Antonio G.</creatorcontrib><creatorcontrib>Tognon, M. Sofia</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Secchi, Antonio G.</au><au>Tognon, M. Sofia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intraoperative Mitomycin C in the Treatment of Cicatricial Obliterations of Conjunctival Fornices</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>122</volume><issue>5</issue><spage>728</spage><epage>730</epage><pages>728-730</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>To investigate whether the intraoperative use of topical mitomycin C improved the postoperative outcome in cases of cicatricial obliteration of conjunctival fornices.
Ten eyes of five patients were subjected to surgical lysis of the synechiae followed by intraoperative application of 0.4 mg mitomycin C per milliliter of saline for 3 to 5 minutes.
After a follow-up period of 12 to 19 months, no recurrence of synechiae was observed, the conjunctival fornices remained open, and conjunctival overgrowths on the cornea did not recur. No adverse effect was observed.
Intraoperative application of mitomycin C proved useful in the surgical treatment of cicatricial shrinkage of conjunctival fornices.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8909216</pmid><doi>10.1016/S0002-9394(14)70495-7</doi><tpages>3</tpages></addata></record> |
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| ispartof | American journal of ophthalmology, 1996-11, Vol.122 (5), p.728-730 |
| issn | 0002-9394 1879-1891 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Administration, Topical Biological and medical sciences Conjunctiva - drug effects Conjunctiva - surgery Conjunctival Diseases - therapy Follow-Up Studies Humans Intraoperative Care Medical sciences Mitomycin - therapeutic use Nucleic Acid Synthesis Inhibitors - therapeutic use Ophthalmic Solutions Pemphigoid, Benign Mucous Membrane - therapy Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the eye and orbit |
| title | Intraoperative Mitomycin C in the Treatment of Cicatricial Obliterations of Conjunctival Fornices |
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