Ventilatory effects of tryptophan depletion in panic disorder: A preliminary report
On the basis of preclinical studies, we hypothesized that deficient serotonin neurotransmission may be associated with the respiratory hyperactivity and carbon dioxide sensitivity seen in panic disorder. We used the tryptophan depletion method to investigate the effects of transient reductions in se...
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| Veröffentlicht in: | Psychiatry research 1996-09, Vol.64 (2), p.83-90 |
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| container_end_page | 90 |
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| container_title | Psychiatry research |
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| creator | Kent, Justine M Coplan, Jeremy D Martinez, Jose Karmally, Wahida Papp, Laszlo A Gorman, Jack M |
| description | On the basis of preclinical studies, we hypothesized that deficient serotonin neurotransmission may be associated with the respiratory hyperactivity and carbon dioxide sensitivity seen in panic disorder. We used the tryptophan depletion method to investigate the effects of transient reductions in serotonin on respiration in five patients with panic disorder and seven normal control subjects. During room air breathing, the patients showed significantly increased ventilation when tryptophan-depleted, while the normal subjects showed no significant changes in respiration. These preliminary data suggest that serotonergic manipulation may affect ventilatory indices, with panic disorder patients being particularly sensitive to the effect of tryptophan depletion. |
| doi_str_mv | 10.1016/0165-1781(96)02840-5 |
| format | Article |
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We used the tryptophan depletion method to investigate the effects of transient reductions in serotonin on respiration in five patients with panic disorder and seven normal control subjects. During room air breathing, the patients showed significantly increased ventilation when tryptophan-depleted, while the normal subjects showed no significant changes in respiration. These preliminary data suggest that serotonergic manipulation may affect ventilatory indices, with panic disorder patients being particularly sensitive to the effect of tryptophan depletion.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Anxiety</subject><subject>Anxiety disorders. Neuroses</subject><subject>Biological and medical sciences</subject><subject>Carbon Dioxide</subject><subject>Diet</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperventilation - etiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Panic disorder</subject><subject>Panic Disorder - blood</subject><subject>Plasma</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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Neuroses</topic><topic>Biological and medical sciences</topic><topic>Carbon Dioxide</topic><topic>Diet</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperventilation - etiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Panic disorder</topic><topic>Panic Disorder - blood</topic><topic>Plasma</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. 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| ispartof | Psychiatry research, 1996-09, Vol.64 (2), p.83-90 |
| issn | 0165-1781 1872-7123 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Adult and adolescent clinical studies Anxiety Anxiety disorders. Neuroses Biological and medical sciences Carbon Dioxide Diet Female Humans Hyperventilation - etiology Male Medical sciences Panic disorder Panic Disorder - blood Plasma Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Respiration Serotonin Serotonin - physiology Tryptophan - blood Tryptophan - deficiency |
| title | Ventilatory effects of tryptophan depletion in panic disorder: A preliminary report |
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