The role of hepatitis C virus specific CD4+ T lymphocytes in acute and chronic hepatitis C
Since the discovery of hepatitis C virus it has become clear that chronic hepatitis C is a major health problem throughout the world. Because antiviral agents are of limited value in the treatment of chronic hepatitis C, research has focused on the antiviral immune response for the development of bo...
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| Veröffentlicht in: | Journal of molecular medicine (Berlin, Germany) Germany), 1996-10, Vol.74 (10), p.583-588 |
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| container_end_page | 588 |
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| container_issue | 10 |
| container_start_page | 583 |
| container_title | Journal of molecular medicine (Berlin, Germany) |
| container_volume | 74 |
| creator | DIEPOLDER, H. M ZACHOVAL, R HOFFMANN, R. M JUNG, M.-C GERLACH, T PAPE, G. R |
| description | Since the discovery of hepatitis C virus it has become clear that chronic hepatitis C is a major health problem throughout the world. Because antiviral agents are of limited value in the treatment of chronic hepatitis C, research has focused on the antiviral immune response for the development of both a protective vaccine and effective immunotherapies for established chronic infection. Antiviral antibodies are present in almost all patients with chronic hepatitis C but do not seem to be virus neutralizing, probably due to the high mutational rate of viral envelope proteins. Studies on the antiviral T cell response have revealed the presence of virus-specific CD4+ helper and CD8+ cytotoxic T cells in a substantial proportion of patients with chronic hepatitis C. Recent studies describe an association between strong CD4+ T helper cell activity to certain hepatitis C virus antigens and a self-limited course of acute hepatitis C and possibly also a sustained response to treatment with interferon-alpha. Therapeutic manipulation of the virus-specific T cell response may thus develop into a new approach for prevention and treatment of hepatitis C virus infection. |
| doi_str_mv | 10.1007/s001090050062 |
| format | Article |
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Recent studies describe an association between strong CD4+ T helper cell activity to certain hepatitis C virus antigens and a self-limited course of acute hepatitis C and possibly also a sustained response to treatment with interferon-alpha. Therapeutic manipulation of the virus-specific T cell response may thus develop into a new approach for prevention and treatment of hepatitis C virus infection.</description><identifier>ISSN: 0946-2716</identifier><identifier>EISSN: 1432-1440</identifier><identifier>DOI: 10.1007/s001090050062</identifier><identifier>PMID: 8912179</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Acute Disease ; Animals ; Antigen Presentation - immunology ; Biological and medical sciences ; Chronic Disease ; Hepacivirus - immunology ; Hepatitis C - immunology ; Hepatitis C - virology ; Hepatitis C Antigens - immunology ; Histocompatibility Antigens Class II - immunology ; Human viral diseases ; Humans ; Infectious diseases ; Medical sciences ; T-Lymphocytes, Helper-Inducer - immunology ; Viral diseases ; Viral hepatitis</subject><ispartof>Journal of molecular medicine (Berlin, Germany), 1996-10, Vol.74 (10), p.583-588</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c317t-41b24cdfbdb638a8736d1ce3b4b30abd8001c98beda48dc5f8ace125014af0453</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3265763$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8912179$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DIEPOLDER, H. M</creatorcontrib><creatorcontrib>ZACHOVAL, R</creatorcontrib><creatorcontrib>HOFFMANN, R. M</creatorcontrib><creatorcontrib>JUNG, M.-C</creatorcontrib><creatorcontrib>GERLACH, T</creatorcontrib><creatorcontrib>PAPE, G. R</creatorcontrib><title>The role of hepatitis C virus specific CD4+ T lymphocytes in acute and chronic hepatitis C</title><title>Journal of molecular medicine (Berlin, Germany)</title><addtitle>J Mol Med (Berl)</addtitle><description>Since the discovery of hepatitis C virus it has become clear that chronic hepatitis C is a major health problem throughout the world. Because antiviral agents are of limited value in the treatment of chronic hepatitis C, research has focused on the antiviral immune response for the development of both a protective vaccine and effective immunotherapies for established chronic infection. Antiviral antibodies are present in almost all patients with chronic hepatitis C but do not seem to be virus neutralizing, probably due to the high mutational rate of viral envelope proteins. Studies on the antiviral T cell response have revealed the presence of virus-specific CD4+ helper and CD8+ cytotoxic T cells in a substantial proportion of patients with chronic hepatitis C. Recent studies describe an association between strong CD4+ T helper cell activity to certain hepatitis C virus antigens and a self-limited course of acute hepatitis C and possibly also a sustained response to treatment with interferon-alpha. Therapeutic manipulation of the virus-specific T cell response may thus develop into a new approach for prevention and treatment of hepatitis C virus infection.</description><subject>Acute Disease</subject><subject>Animals</subject><subject>Antigen Presentation - immunology</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Hepacivirus - immunology</subject><subject>Hepatitis C - immunology</subject><subject>Hepatitis C - virology</subject><subject>Hepatitis C Antigens - immunology</subject><subject>Histocompatibility Antigens Class II - immunology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>T-Lymphocytes, Helper-Inducer - immunology</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><issn>0946-2716</issn><issn>1432-1440</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpV0EtLxDAUBeAgyjiOLl0KWYgbqd482qRLqU8YcDNu3JQkTWik09akFebfW7EMurqL83G4HITOCdwQAHEbAQjkAClARg_QknBGE8I5HKIl5DxLqCDZMTqJ8WOSIs35Ai1kTigR-RK9b2qLQ9dY3Dlc214NfvARF_jLhzHi2FvjnTe4uOfXeIOb3bavO7MbbMS-xcqMg8WqrbCpQ9dO7k_FKTpyqon2bL4r9Pb4sCmek_Xr00txt04MI2JIONGUm8rpSmdMKilYVhFjmeaagdKVnL42udS2UlxWJnVSGUtoCoQrBzxlK3T129uH7nO0cSi3PhrbNKq13RhLIVNKOOUTTH6hCV2MwbqyD36rwq4kUP5sWf7bcvIXc_Got7ba63m8Kb-ccxWNalxQrfFxzxjNUpEx9g1cq3q1</recordid><startdate>19961001</startdate><enddate>19961001</enddate><creator>DIEPOLDER, H. 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| identifier | ISSN: 0946-2716 |
| ispartof | Journal of molecular medicine (Berlin, Germany), 1996-10, Vol.74 (10), p.583-588 |
| issn | 0946-2716 1432-1440 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Acute Disease Animals Antigen Presentation - immunology Biological and medical sciences Chronic Disease Hepacivirus - immunology Hepatitis C - immunology Hepatitis C - virology Hepatitis C Antigens - immunology Histocompatibility Antigens Class II - immunology Human viral diseases Humans Infectious diseases Medical sciences T-Lymphocytes, Helper-Inducer - immunology Viral diseases Viral hepatitis |
| title | The role of hepatitis C virus specific CD4+ T lymphocytes in acute and chronic hepatitis C |
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