Marked enhancement in vivo of paclitaxelʼs (taxolʼs) tumor-regressing activity by ATP-depleting modulation

Paclitaxel alone Is active against the CD8F1 murine spontaneous mammary cancer, and when administered following an ATP-depleting combination of N-(phosphonacetyl)- L-aspartate (PALA) + 6-methylmercaptopurine riboside (MMPR) + 6-aminonicotinamide (6-AN) (PMA) produced significantly enhanced partial t...

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Veröffentlicht in:	Anti-cancer drugs 1996-08, Vol.7 (6), p.655-659
Hauptverfasser:	Martin, Daniel S, Stolfi, Robert L, Colofiore, Joseph R, Nord, L Dee
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Aminonicotinamide - administration & dosage Animals Antineoplastic Agents, Phytogenic - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use Aspartic Acid - administration & dosage Aspartic Acid - analogs & derivatives Female Mammary Neoplasms, Experimental - drug therapy Methylthioinosine - administration & dosage Mice Paclitaxel - therapeutic use Phosphonoacetic Acid - administration & dosage Phosphonoacetic Acid - analogs & derivatives Remission Induction
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