HIV Disease in Children Is Associated with a Selective Decrease in CD23+ and CD62L+ B Cells
We characterized the surface phenotype of B cells from HIV+ children in order to better understand the biology of B cell dysregulation. Twenty-nine HIV-infected, twenty-one exposed, and nineteen age-matched control children were studied for expression of CD5, CD10, CD21, CD23, CD25, CD62L, CD71, and...
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| Veröffentlicht in: | Clinical immunology and immunopathology 1996-11, Vol.81 (2), p.191-199 |
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| container_end_page | 199 |
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| container_title | Clinical immunology and immunopathology |
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| creator | Rodriguez, Cristian Thomas, John K. O'rourke, Sheryl Stiehm, E.Richard Plaeger, Susan |
| description | We characterized the surface phenotype of B cells from HIV+ children in order to better understand the biology of B cell dysregulation. Twenty-nine HIV-infected, twenty-one exposed, and nineteen age-matched control children were studied for expression of CD5, CD10, CD21, CD23, CD25, CD62L, CD71, and CD69. We conclude that, despite persistent high immunoglobulin levels, total B cells decreased as HIV disease progressed, with selective decreases in CD62L+ and CD23+ B cells. This resulted in an increased proportion of usually minor subpopulations of CD62L- and CD23-negative B cells. We did not find significantly altered B cell expression of other activation/immaturity antigens. This suggests an absolute decrease in a subset of antigen-responsive B cells and a disproportionate increase in a subset of hyperstimulated B cells. These findings provide a biological basis for the paradoxical generalized B cell hyperactivity and specific immune unresponsiveness that are characteristic of HIV infection in children. |
| doi_str_mv | 10.1006/clin.1996.0176 |
| format | Article |
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Twenty-nine HIV-infected, twenty-one exposed, and nineteen age-matched control children were studied for expression of CD5, CD10, CD21, CD23, CD25, CD62L, CD71, and CD69. We conclude that, despite persistent high immunoglobulin levels, total B cells decreased as HIV disease progressed, with selective decreases in CD62L+ and CD23+ B cells. This resulted in an increased proportion of usually minor subpopulations of CD62L- and CD23-negative B cells. We did not find significantly altered B cell expression of other activation/immaturity antigens. This suggests an absolute decrease in a subset of antigen-responsive B cells and a disproportionate increase in a subset of hyperstimulated B cells. These findings provide a biological basis for the paradoxical generalized B cell hyperactivity and specific immune unresponsiveness that are characteristic of HIV infection in children.</description><identifier>ISSN: 0090-1229</identifier><identifier>EISSN: 1090-2341</identifier><identifier>DOI: 10.1006/clin.1996.0176</identifier><identifier>PMID: 8906751</identifier><identifier>CODEN: CLIIAT</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>AIDS/HIV ; Antigens, CD - genetics ; Antigens, CD19 - analysis ; Antigens, Differentiation, B-Lymphocyte - genetics ; B-Lymphocyte Subsets - immunology ; B-Lymphocytes - immunology ; Biological and medical sciences ; Child ; Child, Preschool ; Female ; HIV Infections - blood ; human immunodeficiency virus ; Humans ; Hypergammaglobulinemia - immunology ; Immunodeficiencies ; Immunodeficiencies. Immunoglobulinopathies ; Immunopathology ; Infant ; L-Selectin - analysis ; Lymphocyte Count ; Male ; Medical sciences ; Neprilysin - genetics ; Phenotype ; Receptors, IgE - analysis ; Receptors, Transferrin</subject><ispartof>Clinical immunology and immunopathology, 1996-11, Vol.81 (2), p.191-199</ispartof><rights>1996 Academic Press</rights><rights>1997 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-c6d926b868fcfa4b8d8b6485733bdd64e67f2fba6106e7d3a4e9f7539e1cafb73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2479268$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8906751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodriguez, Cristian</creatorcontrib><creatorcontrib>Thomas, John K.</creatorcontrib><creatorcontrib>O'rourke, Sheryl</creatorcontrib><creatorcontrib>Stiehm, E.Richard</creatorcontrib><creatorcontrib>Plaeger, Susan</creatorcontrib><title>HIV Disease in Children Is Associated with a Selective Decrease in CD23+ and CD62L+ B Cells</title><title>Clinical immunology and immunopathology</title><addtitle>Clin Immunol Immunopathol</addtitle><description>We characterized the surface phenotype of B cells from HIV+ children in order to better understand the biology of B cell dysregulation. Twenty-nine HIV-infected, twenty-one exposed, and nineteen age-matched control children were studied for expression of CD5, CD10, CD21, CD23, CD25, CD62L, CD71, and CD69. We conclude that, despite persistent high immunoglobulin levels, total B cells decreased as HIV disease progressed, with selective decreases in CD62L+ and CD23+ B cells. This resulted in an increased proportion of usually minor subpopulations of CD62L- and CD23-negative B cells. We did not find significantly altered B cell expression of other activation/immaturity antigens. This suggests an absolute decrease in a subset of antigen-responsive B cells and a disproportionate increase in a subset of hyperstimulated B cells. These findings provide a biological basis for the paradoxical generalized B cell hyperactivity and specific immune unresponsiveness that are characteristic of HIV infection in children.</description><subject>AIDS/HIV</subject><subject>Antigens, CD - genetics</subject><subject>Antigens, CD19 - analysis</subject><subject>Antigens, Differentiation, B-Lymphocyte - genetics</subject><subject>B-Lymphocyte Subsets - immunology</subject><subject>B-Lymphocytes - immunology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>HIV Infections - blood</subject><subject>human immunodeficiency virus</subject><subject>Humans</subject><subject>Hypergammaglobulinemia - immunology</subject><subject>Immunodeficiencies</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Infant</subject><subject>L-Selectin - analysis</subject><subject>Lymphocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neprilysin - genetics</subject><subject>Phenotype</subject><subject>Receptors, IgE - analysis</subject><subject>Receptors, Transferrin</subject><issn>0090-1229</issn><issn>1090-2341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rGzEQhkVpSJy0194COpRejB1pP_RxTOymMRhySJNLD0IrjbDKejfVrB3676vFxreS07wwzzsMDyFfOJtzxsSNa2M351qLOeNSfCATzjSbFWXFP5IJGzMvCn1BLhF_s1yomDwn50ozIWs-Ib8eVi90GREsAo0dXWxi6xN0dIX0FrF30Q7g6VscNtTSJ2jBDXEPdAkunTrLopxS2_mcRLGe0ju6gLbFT-Qs2Bbh83Fekef77z8XD7P144_V4nY9c6XWw8wJrwvRKKGCC7ZqlFeNqFQty7LxXlQgZChCYwVnAqQvbQU6yLrUwJ0NjSyvyLfD3dfU_9kBDmYb0eUPbAf9Do1UNVeKi3dBLpjkWtUZnB9Al3rEBMG8pri16a_hzIzazajdjNrNqD0Xro-Xd80W_Ak_es77r8e9RWfbkGznIp6wopJZgcqYOmCQde0jJIMuQufAx5TFG9_H_33wD8admwk</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>Rodriguez, Cristian</creator><creator>Thomas, John K.</creator><creator>O'rourke, Sheryl</creator><creator>Stiehm, E.Richard</creator><creator>Plaeger, Susan</creator><general>Elsevier Inc</general><general>Academic Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19961101</creationdate><title>HIV Disease in Children Is Associated with a Selective Decrease in CD23+ and CD62L+ B Cells</title><author>Rodriguez, Cristian ; Thomas, John K. ; O'rourke, Sheryl ; Stiehm, E.Richard ; Plaeger, Susan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-c6d926b868fcfa4b8d8b6485733bdd64e67f2fba6106e7d3a4e9f7539e1cafb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>AIDS/HIV</topic><topic>Antigens, CD - genetics</topic><topic>Antigens, CD19 - analysis</topic><topic>Antigens, Differentiation, B-Lymphocyte - genetics</topic><topic>B-Lymphocyte Subsets - immunology</topic><topic>B-Lymphocytes - immunology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>HIV Infections - blood</topic><topic>human immunodeficiency virus</topic><topic>Humans</topic><topic>Hypergammaglobulinemia - immunology</topic><topic>Immunodeficiencies</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Infant</topic><topic>L-Selectin - analysis</topic><topic>Lymphocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neprilysin - genetics</topic><topic>Phenotype</topic><topic>Receptors, IgE - analysis</topic><topic>Receptors, Transferrin</topic><toplevel>online_resources</toplevel><creatorcontrib>Rodriguez, Cristian</creatorcontrib><creatorcontrib>Thomas, John K.</creatorcontrib><creatorcontrib>O'rourke, Sheryl</creatorcontrib><creatorcontrib>Stiehm, E.Richard</creatorcontrib><creatorcontrib>Plaeger, Susan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodriguez, Cristian</au><au>Thomas, John K.</au><au>O'rourke, Sheryl</au><au>Stiehm, E.Richard</au><au>Plaeger, Susan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HIV Disease in Children Is Associated with a Selective Decrease in CD23+ and CD62L+ B Cells</atitle><jtitle>Clinical immunology and immunopathology</jtitle><addtitle>Clin Immunol Immunopathol</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>81</volume><issue>2</issue><spage>191</spage><epage>199</epage><pages>191-199</pages><issn>0090-1229</issn><eissn>1090-2341</eissn><coden>CLIIAT</coden><abstract>We characterized the surface phenotype of B cells from HIV+ children in order to better understand the biology of B cell dysregulation. Twenty-nine HIV-infected, twenty-one exposed, and nineteen age-matched control children were studied for expression of CD5, CD10, CD21, CD23, CD25, CD62L, CD71, and CD69. We conclude that, despite persistent high immunoglobulin levels, total B cells decreased as HIV disease progressed, with selective decreases in CD62L+ and CD23+ B cells. This resulted in an increased proportion of usually minor subpopulations of CD62L- and CD23-negative B cells. We did not find significantly altered B cell expression of other activation/immaturity antigens. This suggests an absolute decrease in a subset of antigen-responsive B cells and a disproportionate increase in a subset of hyperstimulated B cells. These findings provide a biological basis for the paradoxical generalized B cell hyperactivity and specific immune unresponsiveness that are characteristic of HIV infection in children.</abstract><cop>San Diego, CA</cop><cop>New York, NY</cop><cop>Boston</cop><pub>Elsevier Inc</pub><pmid>8906751</pmid><doi>10.1006/clin.1996.0176</doi><tpages>9</tpages></addata></record> |
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| ispartof | Clinical immunology and immunopathology, 1996-11, Vol.81 (2), p.191-199 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | AIDS/HIV Antigens, CD - genetics Antigens, CD19 - analysis Antigens, Differentiation, B-Lymphocyte - genetics B-Lymphocyte Subsets - immunology B-Lymphocytes - immunology Biological and medical sciences Child Child, Preschool Female HIV Infections - blood human immunodeficiency virus Humans Hypergammaglobulinemia - immunology Immunodeficiencies Immunodeficiencies. Immunoglobulinopathies Immunopathology Infant L-Selectin - analysis Lymphocyte Count Male Medical sciences Neprilysin - genetics Phenotype Receptors, IgE - analysis Receptors, Transferrin |
| title | HIV Disease in Children Is Associated with a Selective Decrease in CD23+ and CD62L+ B Cells |
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