The Carboxyl Termini of β-Amyloid Peptides 1-40 and 1-42 Are Generated by Distinct γ-Secretase Activities

We have studied the effects of peptide aldehyde protease inhibitors on the secretion of β-amyloid peptide 1-40 (Aβ(1-40)) and Aβ(1-42) by HEK 293 and COS-1 cells expressing β-amyloid precursor protein with the Swedish double mutation. A multiphasic SDS-polyacrylamide gel electrophoresis system was u...

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Veröffentlicht in:	The Journal of biological chemistry 1996-11, Vol.271 (45), p.28655-28659
Hauptverfasser:	Klafki, H.-W., Abramowski, D., Swoboda, R., Paganetti, P.A., Staufenbiel, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid beta-Peptides - metabolism Amyloid Precursor Protein Secretases Animals Aspartic Acid Endopeptidases COS Cells Cysteine Proteinase Inhibitors - metabolism Electrophoresis, Polyacrylamide Gel Endopeptidases - metabolism Glycoproteins - metabolism Humans Leupeptins - metabolism Peptide Fragments - metabolism Tumor Cells, Cultured
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