Subcellular Localization and Analysis of Apparent 180-kDa and 220-kDa Proteins of the Breast Cancer Susceptibility Gene, BRCA1

The breast cancer susceptibility gene BRCA1 encodes an 1863-amino acid protein that acts as a tumor suppressor. The biochemical function of BRCA1 is unknown, and there are conflicting results describing its subcellular location. We have identified a 220-kDa protein, which is reactive with three anti...

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Veröffentlicht in:	The Journal of biological chemistry 1996-11, Vol.271 (45), p.28630-28635
Hauptverfasser:	Thomas, James E., Smith, Melanie, Rubinfeld, Bonnee, Gutowski, Magda, Beckmann, Richard P., Polakis, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies BRCA1 Protein - analysis BRCA1 Protein - chemistry Breast Neoplasms - chemistry Female Fluorescent Antibody Technique Genes, BRCA1 Humans Molecular Weight Ovarian Neoplasms - chemistry Subcellular Fractions - chemistry Tumor Cells, Cultured Uterine Cervical Neoplasms - chemistry
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