4-Oxygenated androst-5-en-17-ones and their 7-oxo derivatives as aromatase inhibitors

A series of androst-5-ene-4,7-diones and 4-oxygenated androst-5-enes were synthesized and tested for their ability to inhibit aromatase in human placental microsomes. All of the steroids examined inhibited the enzyme in a competitive manner. The inhibitory activity of 4β-hydroxy-5-ene steroid 7 ( K...

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