Mammalian Mitochondria Possess Homologous DNA Recombination Activity

Mitochondrial protein extracts from normal and immortalized mammalian somatic cells catalyze homologous recombination of plasmid DNA substrates. Mitochondrial homologous recombination activity required exogenous adenosine triphosphate, although substantial activity remained when non-hydrolyzable ana...

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Veröffentlicht in:	The Journal of biological chemistry 1996-11, Vol.271 (44), p.27536-27543
Hauptverfasser:	Thyagarajan, Bhaskar, Padua, Rodolfo A., Campbell, Colin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured DNA Repair DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism Electron Transport Complex IV - biosynthesis Female Fibroblasts - metabolism Fibrosarcoma Humans Mammals Mitochondria - metabolism Mitochondria, Liver - metabolism Models, Genetic Plasmids - metabolism Pyruvate Dehydrogenase Complex - genetics Pyruvate Dehydrogenase Complex Deficiency Disease - genetics Rats Rats, Inbred F344 Recombination, Genetic Skin - metabolism Tumor Cells, Cultured
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