A Potential Role for the Major Iron-Regulated Protein Expressed by Pathogenic Neisseria Species
Several iron-regulated proteins of Neisseria gonorrhoeae and Neisseria meningitidis have been reported. One of these, a 37,000-dalton protein is the major iron-regulated protein (MIRP) and appears to be common among all gonococcal and meningococcal isolates. This protein was purified from both N. go...
Gespeichert in:
| Veröffentlicht in: | Reviews of infectious diseases 1988-07, Vol.10, p.S306-S310 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | S310 |
|---|---|
| container_issue | |
| container_start_page | S306 |
| container_title | Reviews of infectious diseases |
| container_volume | 10 |
| creator | Morse, Stephen A. Cheng-Yen Chen Alain Le Faou Mietzner, Timothy A. |
| description | Several iron-regulated proteins of Neisseria gonorrhoeae and Neisseria meningitidis have been reported. One of these, a 37,000-dalton protein is the major iron-regulated protein (MIRP) and appears to be common among all gonococcal and meningococcal isolates. This protein was purified from both N. gonorrhoeae and N. meningitidis and was found to contain ∼1 mole of Fe⁺⁺⁺/mole of protein. Sera from patients with gonococcal infections contained antibodies to the MIRP. Thus, the MIRP is expressed in vivo. The iron-binding nature of the MIRP suggests that it may have a role in iron acquisition by the pathogenic Neisseria species and, therefore, may have a function in their pathogenicity. |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_78514146</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>4454589</jstor_id><sourcerecordid>4454589</sourcerecordid><originalsourceid>FETCH-LOGICAL-j227t-9cb14f06ddc943ddcdf3321c82b05795aa2ae2b7979afa84cbbf7cd1e0ca47803</originalsourceid><addsrcrecordid>eNo9kE1Lw0AQhnNQaq3-A4U9eQvsZzY5llK1UDVUPYfdzaTdkGbj7gbsvzfQ4mVmeJ-HObxXyRyTjKY4z7Ob5DaEFmPBJM9myYwRTjER86RaotJF6KNVHdq5DlDjPIoHQG-qna6Nd326g_3YqQg1Kv0k2x6tfwcPIUyJPqFSxYPbQ28Negc7pd4q9DmAsRDukutGdQHuL3uRfD-vv1av6fbjZbNabtOWUhnTwmjCG5zVtSk4m2bdMEaJyanGQhZCKaqAalnIQjUq50brRpqaADaKyxyzRfJ0_jt49zNCiNXRBgNdp3pwY6hkLggnPJvEx4s46iPU1eDtUflTdWlk4g9n3obo_D_mXHCRF-wP8J9mTg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78514146</pqid></control><display><type>article</type><title>A Potential Role for the Major Iron-Regulated Protein Expressed by Pathogenic Neisseria Species</title><source>MEDLINE</source><source>JSTOR Archive Collection A-Z Listing</source><creator>Morse, Stephen A. ; Cheng-Yen Chen ; Alain Le Faou ; Mietzner, Timothy A.</creator><creatorcontrib>Morse, Stephen A. ; Cheng-Yen Chen ; Alain Le Faou ; Mietzner, Timothy A.</creatorcontrib><description>Several iron-regulated proteins of Neisseria gonorrhoeae and Neisseria meningitidis have been reported. One of these, a 37,000-dalton protein is the major iron-regulated protein (MIRP) and appears to be common among all gonococcal and meningococcal isolates. This protein was purified from both N. gonorrhoeae and N. meningitidis and was found to contain ∼1 mole of Fe⁺⁺⁺/mole of protein. Sera from patients with gonococcal infections contained antibodies to the MIRP. Thus, the MIRP is expressed in vivo. The iron-binding nature of the MIRP suggests that it may have a role in iron acquisition by the pathogenic Neisseria species and, therefore, may have a function in their pathogenicity.</description><identifier>ISSN: 0162-0886</identifier><identifier>PMID: 3142015</identifier><language>eng</language><publisher>United States: University of Chicago Press</publisher><subject>Amino Acid Sequence ; Amino acids ; Antibodies ; Bacterial Outer Membrane Proteins - analysis ; Bacterial Outer Membrane Proteins - biosynthesis ; Bacterial Proteins ; Gonorrhea - microbiology ; Humans ; Infections ; Iron ; Iron - metabolism ; Iron-Binding Proteins ; Membrane proteins ; Meningococcal Infections - microbiology ; Molecular Sequence Data ; Neisseria ; Neisseria - metabolism ; Neisseria - pathogenicity ; Neisseria gonorrhoeae ; Neisseria gonorrhoeae - metabolism ; Neisseria gonorrhoeae - pathogenicity ; Neisseria meningitidis ; Neisseria meningitidis - metabolism ; Neisseria meningitidis - pathogenicity ; Periplasmic Binding Proteins ; Proteins ; The Cell Envelope of Gram-Negative Bacteria: Structure and Function ; Transferrins ; Virulence</subject><ispartof>Reviews of infectious diseases, 1988-07, Vol.10, p.S306-S310</ispartof><rights>Copyright 1988 The University of Chicago</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4454589$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4454589$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3142015$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morse, Stephen A.</creatorcontrib><creatorcontrib>Cheng-Yen Chen</creatorcontrib><creatorcontrib>Alain Le Faou</creatorcontrib><creatorcontrib>Mietzner, Timothy A.</creatorcontrib><title>A Potential Role for the Major Iron-Regulated Protein Expressed by Pathogenic Neisseria Species</title><title>Reviews of infectious diseases</title><addtitle>Rev Infect Dis</addtitle><description>Several iron-regulated proteins of Neisseria gonorrhoeae and Neisseria meningitidis have been reported. One of these, a 37,000-dalton protein is the major iron-regulated protein (MIRP) and appears to be common among all gonococcal and meningococcal isolates. This protein was purified from both N. gonorrhoeae and N. meningitidis and was found to contain ∼1 mole of Fe⁺⁺⁺/mole of protein. Sera from patients with gonococcal infections contained antibodies to the MIRP. Thus, the MIRP is expressed in vivo. The iron-binding nature of the MIRP suggests that it may have a role in iron acquisition by the pathogenic Neisseria species and, therefore, may have a function in their pathogenicity.</description><subject>Amino Acid Sequence</subject><subject>Amino acids</subject><subject>Antibodies</subject><subject>Bacterial Outer Membrane Proteins - analysis</subject><subject>Bacterial Outer Membrane Proteins - biosynthesis</subject><subject>Bacterial Proteins</subject><subject>Gonorrhea - microbiology</subject><subject>Humans</subject><subject>Infections</subject><subject>Iron</subject><subject>Iron - metabolism</subject><subject>Iron-Binding Proteins</subject><subject>Membrane proteins</subject><subject>Meningococcal Infections - microbiology</subject><subject>Molecular Sequence Data</subject><subject>Neisseria</subject><subject>Neisseria - metabolism</subject><subject>Neisseria - pathogenicity</subject><subject>Neisseria gonorrhoeae</subject><subject>Neisseria gonorrhoeae - metabolism</subject><subject>Neisseria gonorrhoeae - pathogenicity</subject><subject>Neisseria meningitidis</subject><subject>Neisseria meningitidis - metabolism</subject><subject>Neisseria meningitidis - pathogenicity</subject><subject>Periplasmic Binding Proteins</subject><subject>Proteins</subject><subject>The Cell Envelope of Gram-Negative Bacteria: Structure and Function</subject><subject>Transferrins</subject><subject>Virulence</subject><issn>0162-0886</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1Lw0AQhnNQaq3-A4U9eQvsZzY5llK1UDVUPYfdzaTdkGbj7gbsvzfQ4mVmeJ-HObxXyRyTjKY4z7Ob5DaEFmPBJM9myYwRTjER86RaotJF6KNVHdq5DlDjPIoHQG-qna6Nd326g_3YqQg1Kv0k2x6tfwcPIUyJPqFSxYPbQ28Negc7pd4q9DmAsRDukutGdQHuL3uRfD-vv1av6fbjZbNabtOWUhnTwmjCG5zVtSk4m2bdMEaJyanGQhZCKaqAalnIQjUq50brRpqaADaKyxyzRfJ0_jt49zNCiNXRBgNdp3pwY6hkLggnPJvEx4s46iPU1eDtUflTdWlk4g9n3obo_D_mXHCRF-wP8J9mTg</recordid><startdate>19880701</startdate><enddate>19880701</enddate><creator>Morse, Stephen A.</creator><creator>Cheng-Yen Chen</creator><creator>Alain Le Faou</creator><creator>Mietzner, Timothy A.</creator><general>University of Chicago Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19880701</creationdate><title>A Potential Role for the Major Iron-Regulated Protein Expressed by Pathogenic Neisseria Species</title><author>Morse, Stephen A. ; Cheng-Yen Chen ; Alain Le Faou ; Mietzner, Timothy A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j227t-9cb14f06ddc943ddcdf3321c82b05795aa2ae2b7979afa84cbbf7cd1e0ca47803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Amino Acid Sequence</topic><topic>Amino acids</topic><topic>Antibodies</topic><topic>Bacterial Outer Membrane Proteins - analysis</topic><topic>Bacterial Outer Membrane Proteins - biosynthesis</topic><topic>Bacterial Proteins</topic><topic>Gonorrhea - microbiology</topic><topic>Humans</topic><topic>Infections</topic><topic>Iron</topic><topic>Iron - metabolism</topic><topic>Iron-Binding Proteins</topic><topic>Membrane proteins</topic><topic>Meningococcal Infections - microbiology</topic><topic>Molecular Sequence Data</topic><topic>Neisseria</topic><topic>Neisseria - metabolism</topic><topic>Neisseria - pathogenicity</topic><topic>Neisseria gonorrhoeae</topic><topic>Neisseria gonorrhoeae - metabolism</topic><topic>Neisseria gonorrhoeae - pathogenicity</topic><topic>Neisseria meningitidis</topic><topic>Neisseria meningitidis - metabolism</topic><topic>Neisseria meningitidis - pathogenicity</topic><topic>Periplasmic Binding Proteins</topic><topic>Proteins</topic><topic>The Cell Envelope of Gram-Negative Bacteria: Structure and Function</topic><topic>Transferrins</topic><topic>Virulence</topic><toplevel>online_resources</toplevel><creatorcontrib>Morse, Stephen A.</creatorcontrib><creatorcontrib>Cheng-Yen Chen</creatorcontrib><creatorcontrib>Alain Le Faou</creatorcontrib><creatorcontrib>Mietzner, Timothy A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Reviews of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morse, Stephen A.</au><au>Cheng-Yen Chen</au><au>Alain Le Faou</au><au>Mietzner, Timothy A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Potential Role for the Major Iron-Regulated Protein Expressed by Pathogenic Neisseria Species</atitle><jtitle>Reviews of infectious diseases</jtitle><addtitle>Rev Infect Dis</addtitle><date>1988-07-01</date><risdate>1988</risdate><volume>10</volume><spage>S306</spage><epage>S310</epage><pages>S306-S310</pages><issn>0162-0886</issn><abstract>Several iron-regulated proteins of Neisseria gonorrhoeae and Neisseria meningitidis have been reported. One of these, a 37,000-dalton protein is the major iron-regulated protein (MIRP) and appears to be common among all gonococcal and meningococcal isolates. This protein was purified from both N. gonorrhoeae and N. meningitidis and was found to contain ∼1 mole of Fe⁺⁺⁺/mole of protein. Sera from patients with gonococcal infections contained antibodies to the MIRP. Thus, the MIRP is expressed in vivo. The iron-binding nature of the MIRP suggests that it may have a role in iron acquisition by the pathogenic Neisseria species and, therefore, may have a function in their pathogenicity.</abstract><cop>United States</cop><pub>University of Chicago Press</pub><pmid>3142015</pmid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0162-0886 |
| ispartof | Reviews of infectious diseases, 1988-07, Vol.10, p.S306-S310 |
| issn | 0162-0886 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78514146 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing |
| subjects | Amino Acid Sequence Amino acids Antibodies Bacterial Outer Membrane Proteins - analysis Bacterial Outer Membrane Proteins - biosynthesis Bacterial Proteins Gonorrhea - microbiology Humans Infections Iron Iron - metabolism Iron-Binding Proteins Membrane proteins Meningococcal Infections - microbiology Molecular Sequence Data Neisseria Neisseria - metabolism Neisseria - pathogenicity Neisseria gonorrhoeae Neisseria gonorrhoeae - metabolism Neisseria gonorrhoeae - pathogenicity Neisseria meningitidis Neisseria meningitidis - metabolism Neisseria meningitidis - pathogenicity Periplasmic Binding Proteins Proteins The Cell Envelope of Gram-Negative Bacteria: Structure and Function Transferrins Virulence |
| title | A Potential Role for the Major Iron-Regulated Protein Expressed by Pathogenic Neisseria Species |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T09%3A46%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Potential%20Role%20for%20the%20Major%20Iron-Regulated%20Protein%20Expressed%20by%20Pathogenic%20Neisseria%20Species&rft.jtitle=Reviews%20of%20infectious%20diseases&rft.au=Morse,%20Stephen%20A.&rft.date=1988-07-01&rft.volume=10&rft.spage=S306&rft.epage=S310&rft.pages=S306-S310&rft.issn=0162-0886&rft_id=info:doi/&rft_dat=%3Cjstor_proqu%3E4454589%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78514146&rft_id=info:pmid/3142015&rft_jstor_id=4454589&rfr_iscdi=true |