An integrated YAC map of the human X chromosome
The human X chromosome is associated with a large number of disease phenotypes, principally because of its unique mode of inheritance that tends to reveal all recessive disorders in males. With the longer term goal of identifying and characterizing most of these genes, we have adopted a chromosome-w...
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| Veröffentlicht in: | Genome research 1996-10, Vol.6 (10), p.943-955 |
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| creator | Roest Crollius, H Ross, M T Grigoriev, A Knights, C J Holloway, E Misfud, J Li, K Playford, M Gregory, S G Humphray, S J Coffey, A J See, C G Marsh, S Vatcheva, R Kumlien, J Labella, T Lam, V Rak, K H Todd, K Mott, R Graeser, D Rappold, G Zehetner, G Poustka, A Bentley, D R Monaco, A P Lehrach, H |
| description | The human X chromosome is associated with a large number of disease phenotypes, principally because of its unique mode of inheritance that tends to reveal all recessive disorders in males. With the longer term goal of identifying and characterizing most of these genes, we have adopted a chromosome-wide strategy to establish a YAC contig map. We have performed > 3250 inter Alu-PCR product hybridizations to identify overlaps between YAC clones. Positional information associated with many of these YAC clones has been derived from our Reference Library Database and a variety of other public sources. We have constructed a YAC contig map of the X chromosome covering 125 Mb of DNA in 25 contigs and containing 906 YAC clones. These contigs have been verified extensively by FISH and by gel and hybridization fingerprinting techniques. This independently derived map exceeds the coverage of recently reported X chromosome maps built as part of whole-genome YAC maps. |
| doi_str_mv | 10.1101/gr.6.10.943 |
| format | Article |
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With the longer term goal of identifying and characterizing most of these genes, we have adopted a chromosome-wide strategy to establish a YAC contig map. We have performed > 3250 inter Alu-PCR product hybridizations to identify overlaps between YAC clones. Positional information associated with many of these YAC clones has been derived from our Reference Library Database and a variety of other public sources. We have constructed a YAC contig map of the X chromosome covering 125 Mb of DNA in 25 contigs and containing 906 YAC clones. These contigs have been verified extensively by FISH and by gel and hybridization fingerprinting techniques. This independently derived map exceeds the coverage of recently reported X chromosome maps built as part of whole-genome YAC maps.</description><identifier>ISSN: 1088-9051</identifier><identifier>DOI: 10.1101/gr.6.10.943</identifier><identifier>PMID: 8908513</identifier><language>eng</language><publisher>United States</publisher><subject>Chromosome Mapping ; Chromosomes, Artificial, Yeast ; Cloning, Molecular ; DNA Fingerprinting ; Humans ; In Situ Hybridization, Fluorescence ; Male ; X Chromosome</subject><ispartof>Genome research, 1996-10, Vol.6 (10), p.943-955</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c350t-f9e585242227d9d5c9797bfa9f4cf724ae5c9240b689a66c750e8d845fa510333</citedby><cites>FETCH-LOGICAL-c350t-f9e585242227d9d5c9797bfa9f4cf724ae5c9240b689a66c750e8d845fa510333</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8908513$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roest Crollius, H</creatorcontrib><creatorcontrib>Ross, M T</creatorcontrib><creatorcontrib>Grigoriev, A</creatorcontrib><creatorcontrib>Knights, C J</creatorcontrib><creatorcontrib>Holloway, E</creatorcontrib><creatorcontrib>Misfud, J</creatorcontrib><creatorcontrib>Li, K</creatorcontrib><creatorcontrib>Playford, M</creatorcontrib><creatorcontrib>Gregory, S G</creatorcontrib><creatorcontrib>Humphray, S J</creatorcontrib><creatorcontrib>Coffey, A J</creatorcontrib><creatorcontrib>See, C G</creatorcontrib><creatorcontrib>Marsh, S</creatorcontrib><creatorcontrib>Vatcheva, R</creatorcontrib><creatorcontrib>Kumlien, J</creatorcontrib><creatorcontrib>Labella, T</creatorcontrib><creatorcontrib>Lam, V</creatorcontrib><creatorcontrib>Rak, K H</creatorcontrib><creatorcontrib>Todd, K</creatorcontrib><creatorcontrib>Mott, R</creatorcontrib><creatorcontrib>Graeser, D</creatorcontrib><creatorcontrib>Rappold, G</creatorcontrib><creatorcontrib>Zehetner, G</creatorcontrib><creatorcontrib>Poustka, A</creatorcontrib><creatorcontrib>Bentley, D R</creatorcontrib><creatorcontrib>Monaco, A P</creatorcontrib><creatorcontrib>Lehrach, H</creatorcontrib><title>An integrated YAC map of the human X chromosome</title><title>Genome research</title><addtitle>Genome Res</addtitle><description>The human X chromosome is associated with a large number of disease phenotypes, principally because of its unique mode of inheritance that tends to reveal all recessive disorders in males. 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This independently derived map exceeds the coverage of recently reported X chromosome maps built as part of whole-genome YAC maps.</description><subject>Chromosome Mapping</subject><subject>Chromosomes, Artificial, Yeast</subject><subject>Cloning, Molecular</subject><subject>DNA Fingerprinting</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Male</subject><subject>X Chromosome</subject><issn>1088-9051</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEUhbNQaq2uXAtZuZFpb16TZFmKLyi4UdBVSDNJW2kmNZlZ-O-d0uLW1eVcPg6HD6EbAlNCgMzWeVpPh6A5O0NjAkpVGgS5QJelfAEA40qN0EhpUIKwMZrNW7xtO7_OtvMN_pwvcLR7nALuNh5v-mhb_IHdJqeYSor-Cp0Huyv--nQn6P3x4W3xXC1fn14W82XlmICuCtoLJSinlMpGN8JpqeUqWB24C5Jy64cX5bCqlbZ17aQArxrFRbCCAGNsgu6OvfucvntfOhO3xfndzrY-9cXIw3xJ1L8gEVJSRuoBvD-CLqdSsg9mn7fR5h9DwBzcmXU29SEM7gb69lTbr6Jv_tiTOPYLjXlpAw</recordid><startdate>19961001</startdate><enddate>19961001</enddate><creator>Roest Crollius, H</creator><creator>Ross, M T</creator><creator>Grigoriev, A</creator><creator>Knights, C J</creator><creator>Holloway, E</creator><creator>Misfud, J</creator><creator>Li, K</creator><creator>Playford, M</creator><creator>Gregory, S G</creator><creator>Humphray, S J</creator><creator>Coffey, A J</creator><creator>See, C G</creator><creator>Marsh, S</creator><creator>Vatcheva, R</creator><creator>Kumlien, J</creator><creator>Labella, T</creator><creator>Lam, V</creator><creator>Rak, K H</creator><creator>Todd, K</creator><creator>Mott, R</creator><creator>Graeser, D</creator><creator>Rappold, G</creator><creator>Zehetner, G</creator><creator>Poustka, A</creator><creator>Bentley, D R</creator><creator>Monaco, A P</creator><creator>Lehrach, H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19961001</creationdate><title>An integrated YAC map of the human X chromosome</title><author>Roest Crollius, H ; 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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Chromosome Mapping Chromosomes, Artificial, Yeast Cloning, Molecular DNA Fingerprinting Humans In Situ Hybridization, Fluorescence Male X Chromosome |
| title | An integrated YAC map of the human X chromosome |
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