Cell-cell interactions influence oligosaccharide modifications on mucins and other large glycoproteins
Intratumoral phenotypic diversity is well documented with regard to tumor associated carbohydrate antigens (TACA). The factors which control the expression of these cell-surface oligosaccharides on different cells of the same tumor are not understood. We investigated the expression of a panel of muc...
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| Veröffentlicht in: | Glycoconjugate journal 1996-10, Vol.13 (5), p.741-747 |
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| container_issue | 5 |
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| container_title | Glycoconjugate journal |
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| creator | Stranahan, P L Laroe, J McCombs, R Goldsmith, A Rahim, I Overland, M Pettijohn, D E |
| description | Intratumoral phenotypic diversity is well documented with regard to tumor associated carbohydrate antigens (TACA). The factors which control the expression of these cell-surface oligosaccharides on different cells of the same tumor are not understood. We investigated the expression of a panel of mucin associated oligosaccharides in cell lines growing at different surface densities (number of cells per cm2 of growth flask). Results show that the apparent expression of extended Lea-Lex, Lea and Lex, sialyl Lea, Tn and sialyl Tn varies with density of growth by an invasive human squamous cell lung carcinoma cell line (NU6-1), a benign variant (NE-18) and the human lung epithelial cell line BEAS-2B. The results indicate that one of the factors influencing the apparent expression of mucin-associated oligosaccharides is cell-cell interactions. |
| doi_str_mv | 10.1007/BF00702338 |
| format | Article |
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The factors which control the expression of these cell-surface oligosaccharides on different cells of the same tumor are not understood. We investigated the expression of a panel of mucin associated oligosaccharides in cell lines growing at different surface densities (number of cells per cm2 of growth flask). Results show that the apparent expression of extended Lea-Lex, Lea and Lex, sialyl Lea, Tn and sialyl Tn varies with density of growth by an invasive human squamous cell lung carcinoma cell line (NU6-1), a benign variant (NE-18) and the human lung epithelial cell line BEAS-2B. 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The factors which control the expression of these cell-surface oligosaccharides on different cells of the same tumor are not understood. We investigated the expression of a panel of mucin associated oligosaccharides in cell lines growing at different surface densities (number of cells per cm2 of growth flask). Results show that the apparent expression of extended Lea-Lex, Lea and Lex, sialyl Lea, Tn and sialyl Tn varies with density of growth by an invasive human squamous cell lung carcinoma cell line (NU6-1), a benign variant (NE-18) and the human lung epithelial cell line BEAS-2B. The results indicate that one of the factors influencing the apparent expression of mucin-associated oligosaccharides is cell-cell interactions.</description><subject>Antibodies, Monoclonal - immunology</subject><subject>Antibodies, Monoclonal - metabolism</subject><subject>Antigens, Tumor-Associated, Carbohydrate - immunology</subject><subject>Antigens, Tumor-Associated, Carbohydrate - metabolism</subject><subject>Cell Division</subject><subject>Clone Cells</subject><subject>Epitopes - chemistry</subject><subject>Epitopes - genetics</subject><subject>Gene Expression Regulation, Neoplastic - genetics</subject><subject>Humans</subject><subject>Immunoblotting</subject><subject>Immunohistochemistry</subject><subject>Lewis Blood-Group System - analysis</subject><subject>Lewis Blood-Group System - metabolism</subject><subject>Lung Neoplasms - metabolism</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Microscopy, Phase-Contrast</subject><subject>Mucins - immunology</subject><subject>Mucins - metabolism</subject><subject>Oligosaccharides - chemistry</subject><subject>Oligosaccharides - metabolism</subject><subject>Tumor Cells, Cultured</subject><issn>0282-0080</issn><issn>1573-4986</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtPwzAMxyMEGmNw4Y7UEwekQh5tmhxh4iVN4gLnKg9nC2qbkbSHfXsybQJZsh35Zzv-I3RN8D3BuHl4eskeU8bECZqTumFlJQU_RXNMBS0xFvgcXaT0jTNWUTFDMyFzIyZz5JbQdaXJrvDDCFGZ0Ych5YfrJhgMFKHz65CUMRsVvYWiD9Y7b9SBC0PRT8bnTA22COMGYtGpuIZi3e1M2MYwQq5eojOnugRXx7hAXy_Pn8u3cvXx-r58XJUm_3QslXFMS254Iyou66omlmiuGwIN1JRyx7l1FrQB7qTRilOntaCWKCmbyjC2QLeHuXnxzwRpbHuf9tepAcKU2kbUhO1tge4OoIkhpQiu3Ubfq7hrCW73orb_omb45jh10j3YP_SoIvsFNW5z6Q</recordid><startdate>19961001</startdate><enddate>19961001</enddate><creator>Stranahan, P L</creator><creator>Laroe, J</creator><creator>McCombs, R</creator><creator>Goldsmith, A</creator><creator>Rahim, I</creator><creator>Overland, M</creator><creator>Pettijohn, D E</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19961001</creationdate><title>Cell-cell interactions influence oligosaccharide modifications on mucins and other large glycoproteins</title><author>Stranahan, P L ; 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| subjects | Antibodies, Monoclonal - immunology Antibodies, Monoclonal - metabolism Antigens, Tumor-Associated, Carbohydrate - immunology Antigens, Tumor-Associated, Carbohydrate - metabolism Cell Division Clone Cells Epitopes - chemistry Epitopes - genetics Gene Expression Regulation, Neoplastic - genetics Humans Immunoblotting Immunohistochemistry Lewis Blood-Group System - analysis Lewis Blood-Group System - metabolism Lung Neoplasms - metabolism Membrane Glycoproteins - metabolism Microscopy, Phase-Contrast Mucins - immunology Mucins - metabolism Oligosaccharides - chemistry Oligosaccharides - metabolism Tumor Cells, Cultured |
| title | Cell-cell interactions influence oligosaccharide modifications on mucins and other large glycoproteins |
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