Simultaneous serological screening for congenital cytomegalovirus and toxoplasma infection
Sera from mother and baby matched by computer, were examined for evidence of infection with toxoplasma and cytomegalovirus (CMV) in a serological screening programme, based on simultaneous enzyme-linked immunosorbent assays of immunoglobulin G (IgG-ELISA) from a single master dilution of serum. Ther...
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| Veröffentlicht in: | Public health (London) 1988-09, Vol.102 (5), p.409-417 |
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| container_title | Public health (London) |
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| creator | Joss, Alexander W.L. Skinner, Louise J. Chatterton, Jean M.W. Chisholm, Sheila M. Williams, Harry D. Ho-Yen, Darrel O. |
| description | Sera from mother and baby matched by computer, were examined for evidence of infection with toxoplasma and cytomegalovirus (CMV) in a serological screening programme, based on simultaneous enzyme-linked immunosorbent assays of immunoglobulin G (IgG-ELISA) from a single master dilution of serum. There was evidence of primary CMV infection in 23 of 4717 pregnancies (13 by seroconversion in the last two trimesters: 10 by detection of specific IgM at antenatal booking) and primary toxoplasma infection in 10 of 4548 pregnancies (4 by seroconversion; 6 by detection of specific IgM). Detection of seroconversion depended on matching antenatal booking and cord specimen data. The best matching efficiency that could be achieved was 83%. The effectiveness of this approach to identifying neonates at risk of developmental abnormalities is discussed. |
| doi_str_mv | 10.1016/S0033-3506(88)80078-7 |
| format | Article |
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There was evidence of primary CMV infection in 23 of 4717 pregnancies (13 by seroconversion in the last two trimesters: 10 by detection of specific IgM at antenatal booking) and primary toxoplasma infection in 10 of 4548 pregnancies (4 by seroconversion; 6 by detection of specific IgM). Detection of seroconversion depended on matching antenatal booking and cord specimen data. The best matching efficiency that could be achieved was 83%. 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There was evidence of primary CMV infection in 23 of 4717 pregnancies (13 by seroconversion in the last two trimesters: 10 by detection of specific IgM at antenatal booking) and primary toxoplasma infection in 10 of 4548 pregnancies (4 by seroconversion; 6 by detection of specific IgM). Detection of seroconversion depended on matching antenatal booking and cord specimen data. The best matching efficiency that could be achieved was 83%. The effectiveness of this approach to identifying neonates at risk of developmental abnormalities is discussed.</description><subject>Adult</subject><subject>Cytomegalovirus Infections - immunology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin G - analysis</subject><subject>Immunoglobulin M - analysis</subject><subject>Infant, Newborn</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - immunology</subject><subject>Toxoplasmosis, Congenital - immunology</subject><issn>0033-3506</issn><issn>1476-5616</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EKqXwCZWyQrAIjJ3ETlYIVbykSiwKGzaWa08qoyQudlrRv8d9qFtWo9G9dx6HkDGFOwqU388AsizNCuA3ZXlbAogyFSdkSHPB04JTfkqGR8s5uQjhGwCYyIoBGbAyFwzEkHzNbLtqetWhW4UkoHeNW1itmiRoj9jZbpHUzifadYvY9VHQm961uFCNW1sfQ6ozSe9-3bJRoVWJ7WrUvXXdJTmrVRPw6lBH5PP56WPymk7fX94mj9NUM1H0KXKEjGoGBdTxLIYZL-aM55BXRiuDoqqoMfNKCFNDVlNOKx1vxzrHisZMNiLX-7lL735WGHrZ2qCxafZPSVEWlDFOo7HYG7V3IXis5dLbVvmNpCC3TOWOqdwCk2Upd0yliLnxYcFq3qI5pg4Qo_6w1zF-ubboZdAWO43G-ohCGmf_2fAH6WyIJA</recordid><startdate>198809</startdate><enddate>198809</enddate><creator>Joss, Alexander W.L.</creator><creator>Skinner, Louise J.</creator><creator>Chatterton, Jean M.W.</creator><creator>Chisholm, Sheila M.</creator><creator>Williams, Harry D.</creator><creator>Ho-Yen, Darrel O.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198809</creationdate><title>Simultaneous serological screening for congenital cytomegalovirus and toxoplasma infection</title><author>Joss, Alexander W.L. ; Skinner, Louise J. ; Chatterton, Jean M.W. ; Chisholm, Sheila M. ; Williams, Harry D. ; Ho-Yen, Darrel O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c275t-e6e031c2050f2842e365b264049dcade7991ddb977df03f1619c720ef4e9150f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>Cytomegalovirus Infections - immunology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin G - analysis</topic><topic>Immunoglobulin M - analysis</topic><topic>Infant, Newborn</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - immunology</topic><topic>Toxoplasmosis, Congenital - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Joss, Alexander W.L.</creatorcontrib><creatorcontrib>Skinner, Louise J.</creatorcontrib><creatorcontrib>Chatterton, Jean M.W.</creatorcontrib><creatorcontrib>Chisholm, Sheila M.</creatorcontrib><creatorcontrib>Williams, Harry D.</creatorcontrib><creatorcontrib>Ho-Yen, Darrel O.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Public health (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Joss, Alexander W.L.</au><au>Skinner, Louise J.</au><au>Chatterton, Jean M.W.</au><au>Chisholm, Sheila M.</au><au>Williams, Harry D.</au><au>Ho-Yen, Darrel O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Simultaneous serological screening for congenital cytomegalovirus and toxoplasma infection</atitle><jtitle>Public health (London)</jtitle><addtitle>Public Health</addtitle><date>1988-09</date><risdate>1988</risdate><volume>102</volume><issue>5</issue><spage>409</spage><epage>417</epage><pages>409-417</pages><issn>0033-3506</issn><eissn>1476-5616</eissn><abstract>Sera from mother and baby matched by computer, were examined for evidence of infection with toxoplasma and cytomegalovirus (CMV) in a serological screening programme, based on simultaneous enzyme-linked immunosorbent assays of immunoglobulin G (IgG-ELISA) from a single master dilution of serum. There was evidence of primary CMV infection in 23 of 4717 pregnancies (13 by seroconversion in the last two trimesters: 10 by detection of specific IgM at antenatal booking) and primary toxoplasma infection in 10 of 4548 pregnancies (4 by seroconversion; 6 by detection of specific IgM). Detection of seroconversion depended on matching antenatal booking and cord specimen data. The best matching efficiency that could be achieved was 83%. The effectiveness of this approach to identifying neonates at risk of developmental abnormalities is discussed.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>2847207</pmid><doi>10.1016/S0033-3506(88)80078-7</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-3506 |
| ispartof | Public health (London), 1988-09, Vol.102 (5), p.409-417 |
| issn | 0033-3506 1476-5616 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78512261 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Cytomegalovirus Infections - immunology Enzyme-Linked Immunosorbent Assay Female Humans Immunoglobulin G - analysis Immunoglobulin M - analysis Infant, Newborn Pregnancy Pregnancy Complications, Infectious - immunology Toxoplasmosis, Congenital - immunology |
| title | Simultaneous serological screening for congenital cytomegalovirus and toxoplasma infection |
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