Antiserum to endotoxin in hemorrhagic shock
Antiserum to Escherichia coli J5, a mutant endotoxin (LPS) which contains only core determinants, has proven effective in reducing mortality from endotoxic shock due to a wide variety of gram-negative bacteria. Twenty New Zealand white rabbits with coliforms in the gut were subjected to hemorrhagic...
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| Veröffentlicht in: | The Journal of surgical research 1988-11, Vol.45 (5), p.467-471 |
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| container_title | The Journal of surgical research |
| container_volume | 45 |
| creator | Pohlson, Elizabeth C. Suehiro, Anthony Ziegler, Elizabeth J. Suehiro, Glenn McNamara, J.Judson |
| description | Antiserum to
Escherichia coli J5, a mutant endotoxin (LPS) which contains only core determinants, has proven effective in reducing mortality from endotoxic shock due to a wide variety of gram-negative bacteria. Twenty New Zealand white rabbits with coliforms in the gut were subjected to hemorrhagic shock of 36 mm Hg for 3 hr. Treated rabbits were resuscitated with 15 cc of rabbit J5 antiserum (hemagglutinating antibody titer against J5 lipopolysaccharide of 1:1024), remaining shed blood, and lactated Ringer's to achieve a mean arterial blood pressure (MABP) within 20% of baseline. The control group was similarly resuscitated but received 15 cc normal rabbit serum (titer 1:2). Catheters were removed and rabbits were returned to their cages until death or 5 days of survival. Hemodynamic parameters (heart rate, MABP, cardiac output, and total peripheral resistance) did not differ significantly between groups. However, six treated rabbits survived 5 days (60%) and no control rabbit lived past the third postexperimental day (
P < 0.019). Our data suggest that systemic endotoxemia may contribute to morbidity and mortality in severe hemorrhagic shock. |
| doi_str_mv | 10.1016/0022-4804(88)90197-7 |
| format | Article |
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Escherichia coli J5, a mutant endotoxin (LPS) which contains only core determinants, has proven effective in reducing mortality from endotoxic shock due to a wide variety of gram-negative bacteria. Twenty New Zealand white rabbits with coliforms in the gut were subjected to hemorrhagic shock of 36 mm Hg for 3 hr. Treated rabbits were resuscitated with 15 cc of rabbit J5 antiserum (hemagglutinating antibody titer against J5 lipopolysaccharide of 1:1024), remaining shed blood, and lactated Ringer's to achieve a mean arterial blood pressure (MABP) within 20% of baseline. The control group was similarly resuscitated but received 15 cc normal rabbit serum (titer 1:2). Catheters were removed and rabbits were returned to their cages until death or 5 days of survival. Hemodynamic parameters (heart rate, MABP, cardiac output, and total peripheral resistance) did not differ significantly between groups. However, six treated rabbits survived 5 days (60%) and no control rabbit lived past the third postexperimental day (
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Escherichia coli J5, a mutant endotoxin (LPS) which contains only core determinants, has proven effective in reducing mortality from endotoxic shock due to a wide variety of gram-negative bacteria. Twenty New Zealand white rabbits with coliforms in the gut were subjected to hemorrhagic shock of 36 mm Hg for 3 hr. Treated rabbits were resuscitated with 15 cc of rabbit J5 antiserum (hemagglutinating antibody titer against J5 lipopolysaccharide of 1:1024), remaining shed blood, and lactated Ringer's to achieve a mean arterial blood pressure (MABP) within 20% of baseline. The control group was similarly resuscitated but received 15 cc normal rabbit serum (titer 1:2). Catheters were removed and rabbits were returned to their cages until death or 5 days of survival. Hemodynamic parameters (heart rate, MABP, cardiac output, and total peripheral resistance) did not differ significantly between groups. However, six treated rabbits survived 5 days (60%) and no control rabbit lived past the third postexperimental day (
P < 0.019). Our data suggest that systemic endotoxemia may contribute to morbidity and mortality in severe hemorrhagic shock.</description><subject>Alanine Transaminase - metabolism</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Emergency and intensive care: infection, septic shock</subject><subject>Endotoxins - immunology</subject><subject>Escherichia coli - immunology</subject><subject>Immune Sera - immunology</subject><subject>Immunotherapy</subject><subject>Intensive care medicine</subject><subject>Medical sciences</subject><subject>Rabbits</subject><subject>Shock, Hemorrhagic - enzymology</subject><subject>Shock, Hemorrhagic - mortality</subject><subject>Shock, Hemorrhagic - therapy</subject><subject>Time Factors</subject><issn>0022-4804</issn><issn>1095-8673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAQgIMo67r6DxR6EFGkmjTvi7AsvmDBi55DNk3daNto0or-e1O37FEYGIb55sEHwDGCVwgidg1hUeREQHIuxIWESPKc74ApgpLmgnG8C6ZbZB8cxPgGUy05noAJhpTgAk_B5bztXLShb7LOZ7Ytfee_XZulWNvGh7DWr85kce3N-yHYq3Qd7dGYZ-Dl7vZ58ZAvn-4fF_NlbrBgXV5RXlmBEeaSSlmwihSU0IrxdFNzLDktjaFWmxUkkFDOICYUFYIxDVlZEjwDZ5u9H8F_9jZ2qnHR2LrWrfV9VFwkHBGaQLIBTfAxBlupj-AaHX4UgmpwpAYBahCghFB_jhRPYyfj_n7V2HI7NEpJ_dOxr6PRdRV0a1zcYkwKQsnw5s0Gs8nFl7NBReNsa2zpgjWdKr37_49fbdR_mA</recordid><startdate>19881101</startdate><enddate>19881101</enddate><creator>Pohlson, Elizabeth C.</creator><creator>Suehiro, Anthony</creator><creator>Ziegler, Elizabeth J.</creator><creator>Suehiro, Glenn</creator><creator>McNamara, J.Judson</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19881101</creationdate><title>Antiserum to endotoxin in hemorrhagic shock</title><author>Pohlson, Elizabeth C. ; Suehiro, Anthony ; Ziegler, Elizabeth J. ; Suehiro, Glenn ; McNamara, J.Judson</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-f57fe83137959926f42545f67054a73975dcc5eacb0404576034512866a06dd43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Alanine Transaminase - metabolism</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Emergency and intensive care: infection, septic shock</topic><topic>Endotoxins - immunology</topic><topic>Escherichia coli - immunology</topic><topic>Immune Sera - immunology</topic><topic>Immunotherapy</topic><topic>Intensive care medicine</topic><topic>Medical sciences</topic><topic>Rabbits</topic><topic>Shock, Hemorrhagic - enzymology</topic><topic>Shock, Hemorrhagic - mortality</topic><topic>Shock, Hemorrhagic - therapy</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pohlson, Elizabeth C.</creatorcontrib><creatorcontrib>Suehiro, Anthony</creatorcontrib><creatorcontrib>Ziegler, Elizabeth J.</creatorcontrib><creatorcontrib>Suehiro, Glenn</creatorcontrib><creatorcontrib>McNamara, J.Judson</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pohlson, Elizabeth C.</au><au>Suehiro, Anthony</au><au>Ziegler, Elizabeth J.</au><au>Suehiro, Glenn</au><au>McNamara, J.Judson</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiserum to endotoxin in hemorrhagic shock</atitle><jtitle>The Journal of surgical research</jtitle><addtitle>J Surg Res</addtitle><date>1988-11-01</date><risdate>1988</risdate><volume>45</volume><issue>5</issue><spage>467</spage><epage>471</epage><pages>467-471</pages><issn>0022-4804</issn><eissn>1095-8673</eissn><coden>JSGRA2</coden><abstract>Antiserum to
Escherichia coli J5, a mutant endotoxin (LPS) which contains only core determinants, has proven effective in reducing mortality from endotoxic shock due to a wide variety of gram-negative bacteria. Twenty New Zealand white rabbits with coliforms in the gut were subjected to hemorrhagic shock of 36 mm Hg for 3 hr. Treated rabbits were resuscitated with 15 cc of rabbit J5 antiserum (hemagglutinating antibody titer against J5 lipopolysaccharide of 1:1024), remaining shed blood, and lactated Ringer's to achieve a mean arterial blood pressure (MABP) within 20% of baseline. The control group was similarly resuscitated but received 15 cc normal rabbit serum (titer 1:2). Catheters were removed and rabbits were returned to their cages until death or 5 days of survival. Hemodynamic parameters (heart rate, MABP, cardiac output, and total peripheral resistance) did not differ significantly between groups. However, six treated rabbits survived 5 days (60%) and no control rabbit lived past the third postexperimental day (
P < 0.019). Our data suggest that systemic endotoxemia may contribute to morbidity and mortality in severe hemorrhagic shock.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3054323</pmid><doi>10.1016/0022-4804(88)90197-7</doi><tpages>5</tpages></addata></record> |
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| ispartof | The Journal of surgical research, 1988-11, Vol.45 (5), p.467-471 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Alanine Transaminase - metabolism Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Emergency and intensive care: infection, septic shock Endotoxins - immunology Escherichia coli - immunology Immune Sera - immunology Immunotherapy Intensive care medicine Medical sciences Rabbits Shock, Hemorrhagic - enzymology Shock, Hemorrhagic - mortality Shock, Hemorrhagic - therapy Time Factors |
| title | Antiserum to endotoxin in hemorrhagic shock |
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