Direct Activation of the ATP-sensitive Potassium Channel by Oxygen Free Radicals in Guinea-pig Ventricular Cells:its Potentiation by MgADP

The effects of hydrogen peroxide (H 2O 2) on the activity of adenosine 5′-triphosphate-sensitive potassium (K + ATP) channels in ventricular cells isolated from guinea-pig hearts were investigated in inside-out membrane patches using the patch-clamp technique. H 2O 2at concentrations of 5 m mbut not...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 1996-09, Vol.28 (9), p.1867-1877
Hauptverfasser:	Ichinari, Koutarou, Kakei, Masafumi, Matsuoka, Tatsuru, Nakashima, Hitoshi, Tanaka, Hiromitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Adenosine Triphosphate - pharmacology Animals ATP-sensitive K +channel Guinea Pigs Heart Ventricles - cytology Heart Ventricles - drug effects hydrogen peroxide Hydrogen Peroxide - pharmacology In Vitro Techniques Magnesium Chloride - pharmacology patch clamp Patch-Clamp Techniques Potassium Channels - drug effects Potassium Channels - physiology single ventricular myocytes Ventricular Function
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