Relationship of pertussis immunization to the onset of neurologic disorders: A retrospective epidemiologic study
A retrospective epidemiologic study examining the relationship of the time of onset of neurologic disorders with the time of pertussis immunization in two cohorts of children who received pertussis immunization at different ages is reported. Before April 1970, children in Denmark were vaccinated wit...
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| Veröffentlicht in: | The Journal of pediatrics 1988-11, Vol.113 (5), p.801-805 |
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| container_title | The Journal of pediatrics |
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| creator | Shields, W. Donald Nielsen, Claus Buch, Dorte Jacobsen, Vibeke Christenson, Peter Zachau-Christiansen, Bengt Cherry, James D. |
| description | A retrospective epidemiologic study examining the relationship of the time of onset of neurologic disorders with the time of pertussis immunization in two cohorts of children who received pertussis immunization at different ages is reported. Before April 1970, children in Denmark were vaccinated with diphtheria and tetanus toxoids with pertussis vaccine at 5, 6, 7, and 15 months of age. Since 1970, children were given monovalent pertussis vaccine at 5 and 9 weeks and at 10 months of age. A total of 554 cases of epilepsy with onset between 28 days and 24 months of age were reviewed, 286 from the 1967–1968 period and 268 from the 1972–1973 period. There was no relationship between the age of onset of epilepsy and the scheduled age of administration of pertussis vaccine. A total of 2199 children with febrile selzures were reviewed, 830 from the 1967–1968 period and 1369 from the 1972–1973 peroid. There was a statistical association between first febrile seizures and the scheduled age of administration of pertussis vaccine (
p=0.004). No relationship between pertussis immunization and the occurrence of central nervous system infections was noted. |
| doi_str_mv | 10.1016/S0022-3476(88)80004-0 |
| format | Article |
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p=0.004). No relationship between pertussis immunization and the occurrence of central nervous system infections was noted.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(88)80004-0</identifier><identifier>PMID: 3263484</identifier><identifier>CODEN: JOPDAB</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Age Factors ; Bacteriology ; Biological and medical sciences ; Brain Diseases - etiology ; Diphtheria Toxoid - adverse effects ; Diphtheria-Tetanus-Pertussis Vaccine ; Drug Combinations - adverse effects ; Epilepsy - etiology ; Fundamental and applied biological sciences. Psychology ; Humans ; Immunization Schedule ; Infant ; Meningitis - etiology ; Meningoencephalitis - etiology ; Microbiology ; Pertussis Vaccine - adverse effects ; Retrospective Studies ; Seizures - etiology ; Tetanus Toxoid - adverse effects ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><ispartof>The Journal of pediatrics, 1988-11, Vol.113 (5), p.801-805</ispartof><rights>1998 The C.V. Mosby Company</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-1b2b9f9ab527bcb3a8dc17602fa5737bbaba6dc20dc2a0181336e210310d3e8f3</citedby><cites>FETCH-LOGICAL-c536t-1b2b9f9ab527bcb3a8dc17602fa5737bbaba6dc20dc2a0181336e210310d3e8f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0022-3476(88)80004-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6721266$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3263484$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shields, W. Donald</creatorcontrib><creatorcontrib>Nielsen, Claus</creatorcontrib><creatorcontrib>Buch, Dorte</creatorcontrib><creatorcontrib>Jacobsen, Vibeke</creatorcontrib><creatorcontrib>Christenson, Peter</creatorcontrib><creatorcontrib>Zachau-Christiansen, Bengt</creatorcontrib><creatorcontrib>Cherry, James D.</creatorcontrib><title>Relationship of pertussis immunization to the onset of neurologic disorders: A retrospective epidemiologic study</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>A retrospective epidemiologic study examining the relationship of the time of onset of neurologic disorders with the time of pertussis immunization in two cohorts of children who received pertussis immunization at different ages is reported. Before April 1970, children in Denmark were vaccinated with diphtheria and tetanus toxoids with pertussis vaccine at 5, 6, 7, and 15 months of age. Since 1970, children were given monovalent pertussis vaccine at 5 and 9 weeks and at 10 months of age. A total of 554 cases of epilepsy with onset between 28 days and 24 months of age were reviewed, 286 from the 1967–1968 period and 268 from the 1972–1973 period. There was no relationship between the age of onset of epilepsy and the scheduled age of administration of pertussis vaccine. A total of 2199 children with febrile selzures were reviewed, 830 from the 1967–1968 period and 1369 from the 1972–1973 peroid. There was a statistical association between first febrile seizures and the scheduled age of administration of pertussis vaccine (
p=0.004). No relationship between pertussis immunization and the occurrence of central nervous system infections was noted.</description><subject>Age Factors</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Brain Diseases - etiology</subject><subject>Diphtheria Toxoid - adverse effects</subject><subject>Diphtheria-Tetanus-Pertussis Vaccine</subject><subject>Drug Combinations - adverse effects</subject><subject>Epilepsy - etiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Immunization Schedule</subject><subject>Infant</subject><subject>Meningitis - etiology</subject><subject>Meningoencephalitis - etiology</subject><subject>Microbiology</subject><subject>Pertussis Vaccine - adverse effects</subject><subject>Retrospective Studies</subject><subject>Seizures - etiology</subject><subject>Tetanus Toxoid - adverse effects</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2L1TAUhoMo453RnzCQhYguqidJm6ZuhmFwVBgQ_FiHfJw6kbapSTow_np77y136-JwFu9zPngIuWTwjgGT778DcF6JupVvlHqrAKCu4AnZMejaSiohnpLdCXlOznP-vTJdDXBGzgSXolb1jszfcDAlxCnfh5nGns6YypJzyDSM4zKFv4eUlkjLPdKVw7LHJlxSHOKv4KgPOSaPKX-g1zRhSTHP6Ep4QIpz8DiGDcxl8Y8vyLPeDBlfbv2C_Lz9-OPmc3X39dOXm-u7yjVClopZbru-M7bhrXVWGOUdayXw3jStaK011kjvOKxlgCkmhETOQDDwAlUvLsjr4945xT8L5qLHkB0Og5kwLlm3qoFOdrCCzRF06-M5Ya_nFEaTHjUDvTetD6b1XqNWSh9M6_3c5XZgsSP609Smds1fbbnJzgx9MpML-YTJljMu5YpdHTFcZTwETDq7gJNDH9JqUfsY_vPIP4IOnTI</recordid><startdate>19881101</startdate><enddate>19881101</enddate><creator>Shields, W. Donald</creator><creator>Nielsen, Claus</creator><creator>Buch, Dorte</creator><creator>Jacobsen, Vibeke</creator><creator>Christenson, Peter</creator><creator>Zachau-Christiansen, Bengt</creator><creator>Cherry, James D.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19881101</creationdate><title>Relationship of pertussis immunization to the onset of neurologic disorders: A retrospective epidemiologic study</title><author>Shields, W. Donald ; Nielsen, Claus ; Buch, Dorte ; Jacobsen, Vibeke ; Christenson, Peter ; Zachau-Christiansen, Bengt ; Cherry, James D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-1b2b9f9ab527bcb3a8dc17602fa5737bbaba6dc20dc2a0181336e210310d3e8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Age Factors</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>Brain Diseases - etiology</topic><topic>Diphtheria Toxoid - adverse effects</topic><topic>Diphtheria-Tetanus-Pertussis Vaccine</topic><topic>Drug Combinations - adverse effects</topic><topic>Epilepsy - etiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Immunization Schedule</topic><topic>Infant</topic><topic>Meningitis - etiology</topic><topic>Meningoencephalitis - etiology</topic><topic>Microbiology</topic><topic>Pertussis Vaccine - adverse effects</topic><topic>Retrospective Studies</topic><topic>Seizures - etiology</topic><topic>Tetanus Toxoid - adverse effects</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shields, W. Donald</creatorcontrib><creatorcontrib>Nielsen, Claus</creatorcontrib><creatorcontrib>Buch, Dorte</creatorcontrib><creatorcontrib>Jacobsen, Vibeke</creatorcontrib><creatorcontrib>Christenson, Peter</creatorcontrib><creatorcontrib>Zachau-Christiansen, Bengt</creatorcontrib><creatorcontrib>Cherry, James D.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shields, W. Donald</au><au>Nielsen, Claus</au><au>Buch, Dorte</au><au>Jacobsen, Vibeke</au><au>Christenson, Peter</au><au>Zachau-Christiansen, Bengt</au><au>Cherry, James D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship of pertussis immunization to the onset of neurologic disorders: A retrospective epidemiologic study</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1988-11-01</date><risdate>1988</risdate><volume>113</volume><issue>5</issue><spage>801</spage><epage>805</epage><pages>801-805</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><coden>JOPDAB</coden><abstract>A retrospective epidemiologic study examining the relationship of the time of onset of neurologic disorders with the time of pertussis immunization in two cohorts of children who received pertussis immunization at different ages is reported. Before April 1970, children in Denmark were vaccinated with diphtheria and tetanus toxoids with pertussis vaccine at 5, 6, 7, and 15 months of age. Since 1970, children were given monovalent pertussis vaccine at 5 and 9 weeks and at 10 months of age. A total of 554 cases of epilepsy with onset between 28 days and 24 months of age were reviewed, 286 from the 1967–1968 period and 268 from the 1972–1973 period. There was no relationship between the age of onset of epilepsy and the scheduled age of administration of pertussis vaccine. A total of 2199 children with febrile selzures were reviewed, 830 from the 1967–1968 period and 1369 from the 1972–1973 peroid. There was a statistical association between first febrile seizures and the scheduled age of administration of pertussis vaccine (
p=0.004). No relationship between pertussis immunization and the occurrence of central nervous system infections was noted.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>3263484</pmid><doi>10.1016/S0022-3476(88)80004-0</doi><tpages>5</tpages></addata></record> |
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| ispartof | The Journal of pediatrics, 1988-11, Vol.113 (5), p.801-805 |
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| subjects | Age Factors Bacteriology Biological and medical sciences Brain Diseases - etiology Diphtheria Toxoid - adverse effects Diphtheria-Tetanus-Pertussis Vaccine Drug Combinations - adverse effects Epilepsy - etiology Fundamental and applied biological sciences. Psychology Humans Immunization Schedule Infant Meningitis - etiology Meningoencephalitis - etiology Microbiology Pertussis Vaccine - adverse effects Retrospective Studies Seizures - etiology Tetanus Toxoid - adverse effects Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies |
| title | Relationship of pertussis immunization to the onset of neurologic disorders: A retrospective epidemiologic study |
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