The Bioactive Phospholipid, Lysophosphatidylcholine, Induces Cellular Effects via G-Protein-dependent Activation of Adenylyl Cyclase

The naturally occurring phospholipid, lysophosphatidylcholine (lyso-PC), regulates a broad range of cell processes, including gene transcription, mitogenesis, monocyte chemotaxis, smooth muscle relaxation, and platelet activation. Despite the growing list of cellular effects attributable to lyso-PC,...

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Veröffentlicht in:	The Journal of biological chemistry 1996-10, Vol.271 (43), p.27090-27098
Hauptverfasser:	Yuan, Y, Schoenwaelder, S M, Salem, H H, Jackson, S P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - metabolism Blood Platelets - drug effects Blood Platelets - metabolism Blood Proteins - metabolism Cyclic AMP - biosynthesis Cytosol - drug effects Cytosol - metabolism Enzyme Activation GTP-Binding Proteins - metabolism Humans Lysophosphatidylcholines - pharmacology Phosphorylation Platelet Activation - drug effects Platelet Aggregation - drug effects Protein Kinase C - metabolism Signal Transduction Thromboxane A2 - biosynthesis Tyrosine - metabolism
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