NMDA receptor antagonists increase the release of dopamine in the substantia nigra of reserpine-treated rats

Microdialysis of the substantia nigra pars reticulata in freely moving rats disclosed a steady release of dopamine and its metabolites which was greatly reduced after reserpine (4 mg/kg s.c.) and α-methyl- p-tyrosine (200 mg/kg i.p.) pretreatments. Local infusion of high K + (100 mM) or l-3,4-dihydr...

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