Use of YAC fragmentation to delimit a duplicated region on human chromosome 21

One advantage of using yeast artificial chromosomes (YACs) to study complex genomes is the ability to clone large DNA fragments. In addition, since yeasts are able to integrate DNA by homologous recombination, YACs can be modified by targeted transformation, sequences being added or replaced by clon...

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Veröffentlicht in:	Mammalian genome 1996-01, Vol.7 (1), p.85-88
Hauptverfasser:	Potier, M C, Dutriaux, A, Reeves, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Blotting, Southern Chromosomes, Artificial, Yeast - genetics Chromosomes, Human, Pair 21 - genetics Cloning, Molecular Genetic Markers - genetics Genetic Vectors - genetics Humans Molecular Sequence Data Multigene Family - genetics Repetitive Sequences, Nucleic Acid - genetics Sequence Deletion - genetics Telomere - genetics
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