Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree
Schizophrenia is a severe mental illness with a typically chronic course affecting nearly 1% of the human population. It is generally accepted that genetic factors have an important pathogenic role in a substantial portion of schizophrenia cases; however, despite decades of family studies, there is...
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| Veröffentlicht in: | Nature (London) 1988-11, Vol.336 (6195), p.167-170 |
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| creator | Kennedy, James L Giuffra, Luis A Moises, Hans W Cavalli-Sforza, L. L Pakstis, Andrew J Kidd, Judith R Castiglione, Carmela M Sjogren, Barbro Wetterberg, Lennart Kidd, Kenneth K |
| description | Schizophrenia is a severe mental illness with a typically chronic course affecting nearly 1% of the human population. It is generally accepted that genetic factors have an important pathogenic role in a substantial portion of schizophrenia cases; however, despite decades of family studies, there is no agreed-upon mode of inheritance. The discovery of genetic aetiologic factors and resolution of the inheritance pattern(s) will undoubtably emerge from genetic linkage studies. With these objectives in mind, we undertook a linkage project, starting in 1985, in a previously well-documented kindred from north Sweden. Multipoint linkage analyses were used to screen the proximal long arm of chromosome 5 using restriction fragment length polymorphism (RFLP) markers at five loci and the distal long arm using RFLPs at two loci, one of which was the locus for the glucocorticoid receptor. We found strong evidence against linkage between schizophrenia and the seven loci. These results, together with the positive evidence for linkage of schizophrenia with markers in the proximal long arm of chromosome 5 lead us to conclude that the genetic factors underlying schizophrenia are heterogeneous. |
| doi_str_mv | 10.1038/336167a0 |
| format | Article |
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L ; Pakstis, Andrew J ; Kidd, Judith R ; Castiglione, Carmela M ; Sjogren, Barbro ; Wetterberg, Lennart ; Kidd, Kenneth K</creator><creatorcontrib>Kennedy, James L ; Giuffra, Luis A ; Moises, Hans W ; Cavalli-Sforza, L. L ; Pakstis, Andrew J ; Kidd, Judith R ; Castiglione, Carmela M ; Sjogren, Barbro ; Wetterberg, Lennart ; Kidd, Kenneth K</creatorcontrib><description>Schizophrenia is a severe mental illness with a typically chronic course affecting nearly 1% of the human population. It is generally accepted that genetic factors have an important pathogenic role in a substantial portion of schizophrenia cases; however, despite decades of family studies, there is no agreed-upon mode of inheritance. The discovery of genetic aetiologic factors and resolution of the inheritance pattern(s) will undoubtably emerge from genetic linkage studies. With these objectives in mind, we undertook a linkage project, starting in 1985, in a previously well-documented kindred from north Sweden. Multipoint linkage analyses were used to screen the proximal long arm of chromosome 5 using restriction fragment length polymorphism (RFLP) markers at five loci and the distal long arm using RFLPs at two loci, one of which was the locus for the glucocorticoid receptor. We found strong evidence against linkage between schizophrenia and the seven loci. These results, together with the positive evidence for linkage of schizophrenia with markers in the proximal long arm of chromosome 5 lead us to conclude that the genetic factors underlying schizophrenia are heterogeneous.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/336167a0</identifier><identifier>PMID: 2903450</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Biological and medical sciences ; Chromosomes ; Chromosomes, Human, Pair 5 ; Family studies ; Female ; Genetic factors ; Genetics ; Human populations ; Humans ; Male ; Medical sciences ; Mental disorders ; Miscellaneous ; Pedigree ; Polymorphism, Restriction Fragment Length ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Schizophrenia ; Schizophrenia - genetics ; Sweden ; Techniques and methods</subject><ispartof>Nature (London), 1988-11, Vol.336 (6195), p.167-170</ispartof><rights>1990 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Nov 10, 1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-b1bb7f521c16ae074ced813def56a40d123e233b10b5d1176fa7c9b98861a8bf3</citedby><cites>FETCH-LOGICAL-c481t-b1bb7f521c16ae074ced813def56a40d123e233b10b5d1176fa7c9b98861a8bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6771074$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2903450$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kennedy, James L</creatorcontrib><creatorcontrib>Giuffra, Luis A</creatorcontrib><creatorcontrib>Moises, Hans W</creatorcontrib><creatorcontrib>Cavalli-Sforza, L. 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With these objectives in mind, we undertook a linkage project, starting in 1985, in a previously well-documented kindred from north Sweden. Multipoint linkage analyses were used to screen the proximal long arm of chromosome 5 using restriction fragment length polymorphism (RFLP) markers at five loci and the distal long arm using RFLPs at two loci, one of which was the locus for the glucocorticoid receptor. We found strong evidence against linkage between schizophrenia and the seven loci. These results, together with the positive evidence for linkage of schizophrenia with markers in the proximal long arm of chromosome 5 lead us to conclude that the genetic factors underlying schizophrenia are heterogeneous.</description><subject>Biological and medical sciences</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, Pair 5</subject><subject>Family studies</subject><subject>Female</subject><subject>Genetic factors</subject><subject>Genetics</subject><subject>Human populations</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental disorders</subject><subject>Miscellaneous</subject><subject>Pedigree</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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L</au><au>Pakstis, Andrew J</au><au>Kidd, Judith R</au><au>Castiglione, Carmela M</au><au>Sjogren, Barbro</au><au>Wetterberg, Lennart</au><au>Kidd, Kenneth K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree</atitle><jtitle>Nature (London)</jtitle><addtitle>Nature</addtitle><date>1988-11-10</date><risdate>1988</risdate><volume>336</volume><issue>6195</issue><spage>167</spage><epage>170</epage><pages>167-170</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>Schizophrenia is a severe mental illness with a typically chronic course affecting nearly 1% of the human population. It is generally accepted that genetic factors have an important pathogenic role in a substantial portion of schizophrenia cases; however, despite decades of family studies, there is no agreed-upon mode of inheritance. 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| ispartof | Nature (London), 1988-11, Vol.336 (6195), p.167-170 |
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| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | Biological and medical sciences Chromosomes Chromosomes, Human, Pair 5 Family studies Female Genetic factors Genetics Human populations Humans Male Medical sciences Mental disorders Miscellaneous Pedigree Polymorphism, Restriction Fragment Length Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Schizophrenia Schizophrenia - genetics Sweden Techniques and methods |
| title | Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree |
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