NMDA receptors activate the arachidonic acid cascade system in striatal neurons
Receptors for excitatory amino-acid transmitters on nerve cells fall into two main categories associated with non-selective cationic channels, the NMDA (N-methyl-D-aspartate) and non-NMDA (kainate and quisqualate) receptors. Special properties of NMDA receptors such as their voltage-dependent blocka...
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| Veröffentlicht in: | Nature (London) 1988-11, Vol.336 (6194), p.68-70 |
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| creator | Dumuis, A Sebben, M Haynes, L Pin, J. -P Bockaert, J |
| description | Receptors for excitatory amino-acid transmitters on nerve cells fall into two main categories associated with non-selective cationic channels, the NMDA (N-methyl-D-aspartate) and non-NMDA (kainate and quisqualate) receptors. Special properties of NMDA receptors such as their voltage-dependent blockade by Mg2+ (refs 3, 4) and their permeability to Na+, K+ as well as to Ca2+ (refs 5, 6), have led to the suggestion that these receptors are important in plasticity during development and learning. They have been implicated in long-term potentiation (LTP), a model for the study of the cellular mechanisms of learning. We report here that glutamate and NMDA, acting at typical NMDA receptors, stimulate the release of arachidonic acid (as well as 11- and 12-hydroxyeicosatetraenoic acids from striatal neurons probably by stimulation of a Ca2+-dependent phospholipase A2. Kainate and quisqualate, as well as K+-induced depolarization were ineffective. Our results provide direct evidence in favour of the hypothesis, that arachidonic acid derivatives, produced by activation of the postsynaptic cell, could be messengers that cross the synaptic cleft to modify the presynaptic functions known to be altered during LTP. In addition, we suggest that NMDA receptors are the postsynaptic receptors which trigger the synthesis of these putative transynaptic messengers. |
| doi_str_mv | 10.1038/336068a0 |
| format | Article |
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Special properties of NMDA receptors such as their voltage-dependent blockade by Mg2+ (refs 3, 4) and their permeability to Na+, K+ as well as to Ca2+ (refs 5, 6), have led to the suggestion that these receptors are important in plasticity during development and learning. They have been implicated in long-term potentiation (LTP), a model for the study of the cellular mechanisms of learning. We report here that glutamate and NMDA, acting at typical NMDA receptors, stimulate the release of arachidonic acid (as well as 11- and 12-hydroxyeicosatetraenoic acids from striatal neurons probably by stimulation of a Ca2+-dependent phospholipase A2. Kainate and quisqualate, as well as K+-induced depolarization were ineffective. Our results provide direct evidence in favour of the hypothesis, that arachidonic acid derivatives, produced by activation of the postsynaptic cell, could be messengers that cross the synaptic cleft to modify the presynaptic functions known to be altered during LTP. In addition, we suggest that NMDA receptors are the postsynaptic receptors which trigger the synthesis of these putative transynaptic messengers.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/336068a0</identifier><identifier>PMID: 2847054</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Acids ; Arachidonic Acid ; Arachidonic Acids - metabolism ; Biological and medical sciences ; Cell receptors ; Cell structures and functions ; Chemistry ; Chromatography, High Pressure Liquid ; Fundamental and applied biological sciences. Psychology ; Genetics ; Glutamates - pharmacology ; Kainic Acid - pharmacology ; Molecular and cellular biology ; Neurons - metabolism ; Oxadiazoles - pharmacology ; Potassium - pharmacology ; Quisqualic Acid ; Receptors, N-Methyl-D-Aspartate ; Receptors, Neurotransmitter - pharmacology</subject><ispartof>Nature (London), 1988-11, Vol.336 (6194), p.68-70</ispartof><rights>1989 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. 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In addition, we suggest that NMDA receptors are the postsynaptic receptors which trigger the synthesis of these putative transynaptic messengers.</description><subject>Acids</subject><subject>Arachidonic Acid</subject><subject>Arachidonic Acids - metabolism</subject><subject>Biological and medical sciences</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Chemistry</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics</subject><subject>Glutamates - pharmacology</subject><subject>Kainic Acid - pharmacology</subject><subject>Molecular and cellular biology</subject><subject>Neurons - metabolism</subject><subject>Oxadiazoles - pharmacology</subject><subject>Potassium - pharmacology</subject><subject>Quisqualic Acid</subject><subject>Receptors, N-Methyl-D-Aspartate</subject><subject>Receptors, Neurotransmitter - pharmacology</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1v1DAQBmALgcq2IPEHQBZCiEtg7LHH3mNVyodU6AXOkePYqqtssthOpf57stplD1z25MP7aGbkl7FXAj4KQPsJkYCsgydsJZShRpE1T9kKQNoGLNJzdl7KPQBoYdQZO5NWGdBqxW5__vh8yXPwYVunXLjzNT24Gni9C9xl5-9SP43JL0HquXfFuz7w8lhq2PA08lJzctUNfAxznsbygj2Lbijh5eG9YL-_XP-6-tbc3H79fnV503gtqDZOdxiFx65X0VNnu-i91JacIIOE0cdgEH1vY-gVaFSqR22VRFLo7VrjBXu_n7vN0585lNpuUvFhGNwYprm0xmrQa7U-CZE0LJvlSSiFICm0OAmFBmsM0QLf_gfvpzmPy7e0EpSSVhAu6MMe-TyVkkNstzltXH5sBbS7btt_3S709WHe3G1Cf4SHMpf83SHf1TTE7EafypEZgUrS7v43eza6OudwzI97_gLr4rLg</recordid><startdate>19881103</startdate><enddate>19881103</enddate><creator>Dumuis, A</creator><creator>Sebben, M</creator><creator>Haynes, L</creator><creator>Pin, J. -P</creator><creator>Bockaert, J</creator><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7TG</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>KL.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope><scope>7SC</scope><scope>7SP</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>7X8</scope></search><sort><creationdate>19881103</creationdate><title>NMDA receptors activate the arachidonic acid cascade system in striatal neurons</title><author>Dumuis, A ; Sebben, M ; Haynes, L ; Pin, J. -P ; Bockaert, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-a5b3f1c3bd4fc6b8bfcc2586a167363fcfe733cd8fed405344d358423643c8953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Acids</topic><topic>Arachidonic Acid</topic><topic>Arachidonic Acids - metabolism</topic><topic>Biological and medical sciences</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>Chemistry</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics</topic><topic>Glutamates - pharmacology</topic><topic>Kainic Acid - pharmacology</topic><topic>Molecular and cellular biology</topic><topic>Neurons - metabolism</topic><topic>Oxadiazoles - pharmacology</topic><topic>Potassium - pharmacology</topic><topic>Quisqualic Acid</topic><topic>Receptors, N-Methyl-D-Aspartate</topic><topic>Receptors, Neurotransmitter - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dumuis, A</creatorcontrib><creatorcontrib>Sebben, M</creatorcontrib><creatorcontrib>Haynes, L</creatorcontrib><creatorcontrib>Pin, J. -P</creatorcontrib><creatorcontrib>Bockaert, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dumuis, A</au><au>Sebben, M</au><au>Haynes, L</au><au>Pin, J. -P</au><au>Bockaert, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NMDA receptors activate the arachidonic acid cascade system in striatal neurons</atitle><jtitle>Nature (London)</jtitle><addtitle>Nature</addtitle><date>1988-11-03</date><risdate>1988</risdate><volume>336</volume><issue>6194</issue><spage>68</spage><epage>70</epage><pages>68-70</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>Receptors for excitatory amino-acid transmitters on nerve cells fall into two main categories associated with non-selective cationic channels, the NMDA (N-methyl-D-aspartate) and non-NMDA (kainate and quisqualate) receptors. 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In addition, we suggest that NMDA receptors are the postsynaptic receptors which trigger the synthesis of these putative transynaptic messengers.</abstract><cop>London</cop><pub>Nature Publishing</pub><pmid>2847054</pmid><doi>10.1038/336068a0</doi><tpages>3</tpages></addata></record> |
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| ispartof | Nature (London), 1988-11, Vol.336 (6194), p.68-70 |
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| subjects | Acids Arachidonic Acid Arachidonic Acids - metabolism Biological and medical sciences Cell receptors Cell structures and functions Chemistry Chromatography, High Pressure Liquid Fundamental and applied biological sciences. Psychology Genetics Glutamates - pharmacology Kainic Acid - pharmacology Molecular and cellular biology Neurons - metabolism Oxadiazoles - pharmacology Potassium - pharmacology Quisqualic Acid Receptors, N-Methyl-D-Aspartate Receptors, Neurotransmitter - pharmacology |
| title | NMDA receptors activate the arachidonic acid cascade system in striatal neurons |
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