Genetic contribution of polymorphism of the GLUT1 and GLUT4 genes to the susceptibility to type 2 (non-insulin-dependent) diabetes mellitus in different populations
Polymorphic variation of genes encoding the glucose transporters glycoproteins (GLUT) may contribute to the genetic susceptibility to type 2 (non-insulin-dependent) diabetes. In this study we evaluated the allele and genotype frequencies of GLUT1 and GLUT4 restriction fragment length polymorphism (R...
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| Veröffentlicht in: | Acta diabetologica 1996-09, Vol.33 (3), p.193-197 |
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| container_title | Acta diabetologica |
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| creator | PONTIROLI, A. E CAPRA, F KOPELMAN, P. G MOHAN, V VISWANATHAN, M VEGLIA, F FERRARI, M XIANG, K. S BELL, G. I BARONI, M. G GALTON, D. J WEAVER, J. U HITMAN, G. A |
| description | Polymorphic variation of genes encoding the glucose transporters glycoproteins (GLUT) may contribute to the genetic susceptibility to type 2 (non-insulin-dependent) diabetes. In this study we evaluated the allele and genotype frequencies of GLUT1 and GLUT4 restriction fragment length polymorphism (RFLP), revealed by digestion with XbaI for GLUT1 and KpnI for GLUT4, in Caucasian, Chinese, Japanese, Asian Indian and American black populations. No differences of the KpnI GLUT 4 RFLP were found between control and diabetic subjects in any ethnic group or when all data are combined. In contrast, positive results were found for the XbaI RFLP: (1) most ethnic groups showed an association of allele 1 with type 2 diabetes, and this association was maintained when all groups were analysed together; (2) after stratifying for sex and obesity, this association was significant only for overweight/obese women. This joint analysis suggests that GLUT1 polymorphism may contribute to susceptibility to type 2 diabetes in some populations, and especially in overweight/obese women. |
| doi_str_mv | 10.1007/bf02048542 |
| format | Article |
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E ; CAPRA, F ; KOPELMAN, P. G ; MOHAN, V ; VISWANATHAN, M ; VEGLIA, F ; FERRARI, M ; XIANG, K. S ; BELL, G. I ; BARONI, M. G ; GALTON, D. J ; WEAVER, J. U ; HITMAN, G. A</creator><creatorcontrib>PONTIROLI, A. E ; CAPRA, F ; KOPELMAN, P. G ; MOHAN, V ; VISWANATHAN, M ; VEGLIA, F ; FERRARI, M ; XIANG, K. S ; BELL, G. I ; BARONI, M. G ; GALTON, D. J ; WEAVER, J. U ; HITMAN, G. A</creatorcontrib><description>Polymorphic variation of genes encoding the glucose transporters glycoproteins (GLUT) may contribute to the genetic susceptibility to type 2 (non-insulin-dependent) diabetes. In this study we evaluated the allele and genotype frequencies of GLUT1 and GLUT4 restriction fragment length polymorphism (RFLP), revealed by digestion with XbaI for GLUT1 and KpnI for GLUT4, in Caucasian, Chinese, Japanese, Asian Indian and American black populations. No differences of the KpnI GLUT 4 RFLP were found between control and diabetic subjects in any ethnic group or when all data are combined. In contrast, positive results were found for the XbaI RFLP: (1) most ethnic groups showed an association of allele 1 with type 2 diabetes, and this association was maintained when all groups were analysed together; (2) after stratifying for sex and obesity, this association was significant only for overweight/obese women. This joint analysis suggests that GLUT1 polymorphism may contribute to susceptibility to type 2 diabetes in some populations, and especially in overweight/obese women.</description><identifier>ISSN: 0940-5429</identifier><identifier>EISSN: 1432-5233</identifier><identifier>DOI: 10.1007/bf02048542</identifier><identifier>PMID: 8904924</identifier><language>eng</language><publisher>Berlin: Springer International</publisher><subject>Adult ; Alleles ; Biological and medical sciences ; Body Mass Index ; Chi-Square Distribution ; Confidence Intervals ; Continental Population Groups - genetics ; Deoxyribonucleases, Type II Site-Specific ; Diabetes Mellitus, Type 2 - genetics ; Diabetes. Impaired glucose tolerance ; Disease Susceptibility ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Ethnic Groups - genetics ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Gene Frequency ; Genetic Variation ; Genotype ; Glucose Transporter Type 1 ; Glucose Transporter Type 4 ; Humans ; Male ; Medical sciences ; Middle Aged ; Monosaccharide Transport Proteins - genetics ; Muscle Proteins ; Odds Ratio ; Polymorphism, Genetic ; Polymorphism, Restriction Fragment Length ; Sex Factors</subject><ispartof>Acta diabetologica, 1996-09, Vol.33 (3), p.193-197</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-b612659cdda3a02adebea3372dc72ae35c96cfa35f4dd38573d55cae5e5f665f3</citedby><cites>FETCH-LOGICAL-c379t-b612659cdda3a02adebea3372dc72ae35c96cfa35f4dd38573d55cae5e5f665f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27906,27907</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3231648$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8904924$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PONTIROLI, A. E</creatorcontrib><creatorcontrib>CAPRA, F</creatorcontrib><creatorcontrib>KOPELMAN, P. G</creatorcontrib><creatorcontrib>MOHAN, V</creatorcontrib><creatorcontrib>VISWANATHAN, M</creatorcontrib><creatorcontrib>VEGLIA, F</creatorcontrib><creatorcontrib>FERRARI, M</creatorcontrib><creatorcontrib>XIANG, K. S</creatorcontrib><creatorcontrib>BELL, G. I</creatorcontrib><creatorcontrib>BARONI, M. G</creatorcontrib><creatorcontrib>GALTON, D. J</creatorcontrib><creatorcontrib>WEAVER, J. U</creatorcontrib><creatorcontrib>HITMAN, G. A</creatorcontrib><title>Genetic contribution of polymorphism of the GLUT1 and GLUT4 genes to the susceptibility to type 2 (non-insulin-dependent) diabetes mellitus in different populations</title><title>Acta diabetologica</title><addtitle>Acta Diabetol</addtitle><description>Polymorphic variation of genes encoding the glucose transporters glycoproteins (GLUT) may contribute to the genetic susceptibility to type 2 (non-insulin-dependent) diabetes. In this study we evaluated the allele and genotype frequencies of GLUT1 and GLUT4 restriction fragment length polymorphism (RFLP), revealed by digestion with XbaI for GLUT1 and KpnI for GLUT4, in Caucasian, Chinese, Japanese, Asian Indian and American black populations. No differences of the KpnI GLUT 4 RFLP were found between control and diabetic subjects in any ethnic group or when all data are combined. In contrast, positive results were found for the XbaI RFLP: (1) most ethnic groups showed an association of allele 1 with type 2 diabetes, and this association was maintained when all groups were analysed together; (2) after stratifying for sex and obesity, this association was significant only for overweight/obese women. This joint analysis suggests that GLUT1 polymorphism may contribute to susceptibility to type 2 diabetes in some populations, and especially in overweight/obese women.</description><subject>Adult</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Chi-Square Distribution</subject><subject>Confidence Intervals</subject><subject>Continental Population Groups - genetics</subject><subject>Deoxyribonucleases, Type II Site-Specific</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Disease Susceptibility</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Ethnic Groups - genetics</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Variation</subject><subject>Genotype</subject><subject>Glucose Transporter Type 1</subject><subject>Glucose Transporter Type 4</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Monosaccharide Transport Proteins - genetics</subject><subject>Muscle Proteins</subject><subject>Odds Ratio</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Sex Factors</subject><issn>0940-5429</issn><issn>1432-5233</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kTtvFDEUhS0ECptAQ4_kAiFAmuDnPEqIkiXSSmmSeuSxr4mRxx5sT7H_hx8a72ZJZfuc7x5d6yD0gZJLSkj3fbKEEdFLwV6hDRWcNZJx_hptyCBIU-XhLTrP-Q8hlHW8P0Nn_UDEwMQG_dtCgOI01jGU5Ka1uBhwtHiJfj_HtDy6PB_e5RHwdvdwT7EK5ngT-HedzbjEo5nXrGEpbnLelf1R3S-AGf4SYmhcyKt3oTGwQDAQyldsnJqg1IAZfB1ZM3ahitZCqn5dYFm9OqyT36E3VvkM70_nBXq4ub6_-tXs7ra3Vz92jebdUJqppayVgzZGcUWYMjCB4rxjRndMAZd6aLVVXFphDO9lx42UWoEEadtWWn6BPj_nLin-XSGXcXb1U96rAHHNY9dLIqlsK_jtGdQp5pzAjktys0r7kZLxUMn48-Z_JRX-eEpdpxnMC3rqoPqfTr7KWnmbVNAuv2CccdqKnj8B7L2Wew</recordid><startdate>19960901</startdate><enddate>19960901</enddate><creator>PONTIROLI, A. 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Target tissue resistance</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Variation</topic><topic>Genotype</topic><topic>Glucose Transporter Type 1</topic><topic>Glucose Transporter Type 4</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Monosaccharide Transport Proteins - genetics</topic><topic>Muscle Proteins</topic><topic>Odds Ratio</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PONTIROLI, A. E</creatorcontrib><creatorcontrib>CAPRA, F</creatorcontrib><creatorcontrib>KOPELMAN, P. G</creatorcontrib><creatorcontrib>MOHAN, V</creatorcontrib><creatorcontrib>VISWANATHAN, M</creatorcontrib><creatorcontrib>VEGLIA, F</creatorcontrib><creatorcontrib>FERRARI, M</creatorcontrib><creatorcontrib>XIANG, K. S</creatorcontrib><creatorcontrib>BELL, G. 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A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic contribution of polymorphism of the GLUT1 and GLUT4 genes to the susceptibility to type 2 (non-insulin-dependent) diabetes mellitus in different populations</atitle><jtitle>Acta diabetologica</jtitle><addtitle>Acta Diabetol</addtitle><date>1996-09-01</date><risdate>1996</risdate><volume>33</volume><issue>3</issue><spage>193</spage><epage>197</epage><pages>193-197</pages><issn>0940-5429</issn><eissn>1432-5233</eissn><abstract>Polymorphic variation of genes encoding the glucose transporters glycoproteins (GLUT) may contribute to the genetic susceptibility to type 2 (non-insulin-dependent) diabetes. In this study we evaluated the allele and genotype frequencies of GLUT1 and GLUT4 restriction fragment length polymorphism (RFLP), revealed by digestion with XbaI for GLUT1 and KpnI for GLUT4, in Caucasian, Chinese, Japanese, Asian Indian and American black populations. No differences of the KpnI GLUT 4 RFLP were found between control and diabetic subjects in any ethnic group or when all data are combined. In contrast, positive results were found for the XbaI RFLP: (1) most ethnic groups showed an association of allele 1 with type 2 diabetes, and this association was maintained when all groups were analysed together; (2) after stratifying for sex and obesity, this association was significant only for overweight/obese women. This joint analysis suggests that GLUT1 polymorphism may contribute to susceptibility to type 2 diabetes in some populations, and especially in overweight/obese women.</abstract><cop>Berlin</cop><pub>Springer International</pub><pmid>8904924</pmid><doi>10.1007/bf02048542</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0940-5429 |
| ispartof | Acta diabetologica, 1996-09, Vol.33 (3), p.193-197 |
| issn | 0940-5429 1432-5233 |
| language | eng |
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| subjects | Adult Alleles Biological and medical sciences Body Mass Index Chi-Square Distribution Confidence Intervals Continental Population Groups - genetics Deoxyribonucleases, Type II Site-Specific Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance Disease Susceptibility Endocrine pancreas. Apud cells (diseases) Endocrinopathies Ethnic Groups - genetics Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Gene Frequency Genetic Variation Genotype Glucose Transporter Type 1 Glucose Transporter Type 4 Humans Male Medical sciences Middle Aged Monosaccharide Transport Proteins - genetics Muscle Proteins Odds Ratio Polymorphism, Genetic Polymorphism, Restriction Fragment Length Sex Factors |
| title | Genetic contribution of polymorphism of the GLUT1 and GLUT4 genes to the susceptibility to type 2 (non-insulin-dependent) diabetes mellitus in different populations |
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