In vivo nitrate tolerance is not associated with reduced bioconversion of nitroglycerin to nitric oxide

In vitro data suggest that reduced bioconversion of nitroglycerin (NTG) to nitric oxide (NO) contributes to the development of vascular and hemodynamic tolerance to NTG. We examined the in vivo validity of this hypothesis by measuring NTG-derived NO formation by in vivo spin-trapping of NO in vascul...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1996-11, Vol.94 (9), p.2241-2247
Hauptverfasser:	JØRN BECH LAURSEN, MÜLSCH, A, BOESGAARD, S, MORDVINTCEV, P, TRAUTNER, S, GRUHN, N, NIELSEN-KUDSK, J. E, BUSSE, R, ALDERSHVILE, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antianginal agents. Coronary vasodilator agents Biological and medical sciences Blood Vessels - drug effects Cardiovascular system Dose-Response Relationship, Drug Drug Tolerance - physiology Female Infusions, Intravenous Medical sciences Nitrates - metabolism Nitric Oxide - biosynthesis Nitroglycerin - metabolism Nitroglycerin - pharmacology Pharmacology. Drug treatments Rats Rats, Wistar Spin Trapping Time Factors
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