Inhibitors of cyclic AMP phosphodiesterase. 3. Synthesis and biological evaluation of pyrido and imidazolyl analogs of 1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazoline

Hybridization of structural elements of 1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazoline ring system common to the cyclic AMP (cAMP) phosphodiesterase (PDE) inhibitors lixazinone (RS-82856, 1) and anagrelide (3) with complementary features of other PDE inhibitor cardiotonic agents prompted the desi...

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Veröffentlicht in:	Journal of medicinal chemistry 1988-11, Vol.31 (11), p.2136-2145
Hauptverfasser:	Venuti, Michael C, Stephenson, Robert A, Alvarez, Robert, Bruno, John J, Strosberg, Arthur M
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2,3,5-tetrahydro-2-oxoimidazo(2,1-b)quinazoline 3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors Animals Blood Platelets - enzymology Cardiotonic Agents - chemical synthesis Cardiotonic Agents - pharmacology Dogs Drug Evaluation Heart Failure - enzymology Humans Myocardium - enzymology Platelet Aggregation - drug effects Quinazolines Structure-Activity Relationship
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