Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

Exposure of mammalian cells to ultraviolet (UV) light or high osmolarity strongly activates the c-Jun amino-terminal protein kinase (JNK) cascade, causing induction of many target genes. Exposure to UV light or osmotic shock induced clustering and internalization of cell surface receptors for epider...

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Veröffentlicht in:	Science 1996-11, Vol.274 (5290), p.1194-1197
Hauptverfasser:	Rosette, Caridad, Karin, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Aggregation Amino acids ANIMAL CELLS Antibodies BIOCHEMISTRY Biological and medical sciences Biological effects of radiation BIOLOGY AND MEDICINE, APPLIED STUDIES Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell growth Cell physiology Cell surface receptors Cells Cells (Biology) Cellular biology Cytokines Dimerization Effect of radiation on Enzyme Activation Epidermal Growth Factor - pharmacology ErbB Receptors - metabolism Fluorescent Antibody Technique, Indirect Fundamental and applied biological sciences. Psychology Genes GENETIC RADIATION EFFECTS GRB2 Adaptor Protein HeLa Cells Humans Interleukin-1 - pharmacology Internalization Irradiation JNK Mitogen-Activated Protein Kinases Ligands Mitogen-Activated Protein Kinases Non ionizing radiations. Hertzian waves. Biooptics Osmotic Pressure Phosphorylation Physiological aspects Proteins Proteins - metabolism Radiation effects Receptors Receptors, Interleukin-1 - metabolism Receptors, Tumor Necrosis Factor - metabolism Signal Transduction Temperature Tissues, organs and organisms biophysics TNF Receptor-Associated Factor 1 Tumor Necrosis Factor-alpha - pharmacology ULTRAVIOLET RADIATION Ultraviolet Rays
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