Mapping of a Gene for Parkinson's Disease to Chromosome 4q21-q23
Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately 1 percent of the population over age 50. Recent studies have confirmed significant familial aggregation of PD and a large number of large multicase families have...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1996-11, Vol.274 (5290), p.1197-1199 |
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| creator | Polymeropoulos, Mihael H. Higgins, Joseph J. Golbe, Lawrence I. Johnson, William G. Ide, Susan E. Di Iorio, Giuseppe Sanges, Giuseppe Stenroos, Edward S. Pho, Lana T. Schaffer, Alejandro A. Lazzarini, Alice M. Nussbaum, Robert L. Duvoisin, Roger C. |
| description | Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately 1 percent of the population over age 50. Recent studies have confirmed significant familial aggregation of PD and a large number of large multicase families have been documented. Genetic markers on chromosome 4q21-q23 were found to be linked to the PD phenotype in large kindred with autosomal dominant PD, with a Z$_{max}$=6.00 for marker D4S2380. This facilitate identification of the gene and research on the pathogenesis of PD. |
| doi_str_mv | 10.1126/science.274.5290.1197 |
| format | Article |
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Recent studies have confirmed significant familial aggregation of PD and a large number of large multicase families have been documented. Genetic markers on chromosome 4q21-q23 were found to be linked to the PD phenotype in large kindred with autosomal dominant PD, with a Z$_{max}$=6.00 for marker D4S2380. This facilitate identification of the gene and research on the pathogenesis of PD.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.274.5290.1197</identifier><identifier>PMID: 8895469</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Anatomy ; Biological and medical sciences ; Chromosome Mapping ; Chromosomes ; Chromosomes, Human, Pair 4 ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Environmental Influences ; Etiology ; Family (Sociological Unit) ; Female ; Genes ; Genetic aspects ; Genetic Linkage ; Genetic loci ; Genetic Markers ; Genetics ; Heredity ; Humans ; Lod Score ; Male ; Medical research ; Medical sciences ; Nervous system diseases ; Neurodegenerative diseases ; Neurology ; Parkinson disease ; Parkinson Disease - genetics ; Parkinson's disease ; Pathology ; Pedigree ; Phenotype ; Phenotypes</subject><ispartof>Science (American Association for the Advancement of Science), 1996-11, Vol.274 (5290), p.1197-1199</ispartof><rights>Copyright 1996 American Association for the Advancement of Science</rights><rights>1997 INIST-CNRS</rights><rights>COPYRIGHT 1996 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1996 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Nov 15, 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c886t-9a93c4f1f9019493a31d9eb663a2f5f7d40f6f2f0a416c1c88708ed01db6fa6c3</citedby><cites>FETCH-LOGICAL-c886t-9a93c4f1f9019493a31d9eb663a2f5f7d40f6f2f0a416c1c88708ed01db6fa6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2891594$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2891594$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,782,786,805,2886,2887,27931,27932,58024,58257</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2483262$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8895469$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Polymeropoulos, Mihael H.</creatorcontrib><creatorcontrib>Higgins, Joseph J.</creatorcontrib><creatorcontrib>Golbe, Lawrence I.</creatorcontrib><creatorcontrib>Johnson, William G.</creatorcontrib><creatorcontrib>Ide, Susan E.</creatorcontrib><creatorcontrib>Di Iorio, Giuseppe</creatorcontrib><creatorcontrib>Sanges, Giuseppe</creatorcontrib><creatorcontrib>Stenroos, Edward S.</creatorcontrib><creatorcontrib>Pho, Lana T.</creatorcontrib><creatorcontrib>Schaffer, Alejandro A.</creatorcontrib><creatorcontrib>Lazzarini, Alice M.</creatorcontrib><creatorcontrib>Nussbaum, Robert L.</creatorcontrib><creatorcontrib>Duvoisin, Roger C.</creatorcontrib><title>Mapping of a Gene for Parkinson's Disease to Chromosome 4q21-q23</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Parkinson's disease (PD) is the second most common neurodegenerative disorder after Alzheimer's disease, affecting approximately 1 percent of the population over age 50. Recent studies have confirmed significant familial aggregation of PD and a large number of large multicase families have been documented. Genetic markers on chromosome 4q21-q23 were found to be linked to the PD phenotype in large kindred with autosomal dominant PD, with a Z$_{max}$=6.00 for marker D4S2380. This facilitate identification of the gene and research on the pathogenesis of PD.</description><subject>Anatomy</subject><subject>Biological and medical sciences</subject><subject>Chromosome Mapping</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, Pair 4</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. 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Leukodystrophies. 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Recent studies have confirmed significant familial aggregation of PD and a large number of large multicase families have been documented. Genetic markers on chromosome 4q21-q23 were found to be linked to the PD phenotype in large kindred with autosomal dominant PD, with a Z$_{max}$=6.00 for marker D4S2380. This facilitate identification of the gene and research on the pathogenesis of PD.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>8895469</pmid><doi>10.1126/science.274.5290.1197</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1996-11, Vol.274 (5290), p.1197-1199 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78500387 |
| source | MEDLINE; Science Magazine; JSTOR Archive Collection A-Z Listing |
| subjects | Anatomy Biological and medical sciences Chromosome Mapping Chromosomes Chromosomes, Human, Pair 4 Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Environmental Influences Etiology Family (Sociological Unit) Female Genes Genetic aspects Genetic Linkage Genetic loci Genetic Markers Genetics Heredity Humans Lod Score Male Medical research Medical sciences Nervous system diseases Neurodegenerative diseases Neurology Parkinson disease Parkinson Disease - genetics Parkinson's disease Pathology Pedigree Phenotype Phenotypes |
| title | Mapping of a Gene for Parkinson's Disease to Chromosome 4q21-q23 |
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