The primary structure of the 70 kDa subunit of bovine soluble guanylate cyclase
The primary structure of the 70 kDa subunit of soluble bovine guanylate cyclase, which catalyzes the formation of cyclic GMP from GTP, has been determined. The alignment of six different clones out of two bovine libraries yielded a total of 3.1 kb with a coding region of 1857 bases. The open reading...
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| Veröffentlicht in: | FEBS letters 1988-10, Vol.239 (1), p.29-34 |
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| creator | Koesling, Doris Herz, Joachim Gausepohl, Heinrich Niroomand, Feraydoon Hinsch, Klaus-Dieter Mülsch, Alexander Böhme, Eycke Schultz, Günter Frank, Rainer |
| description | The primary structure of the 70 kDa subunit of soluble bovine guanylate cyclase, which catalyzes the formation of cyclic GMP from GTP, has been determined. The alignment of six different clones out of two bovine libraries yielded a total of 3.1 kb with a coding region of 1857 bases. The open reading frame encodes a protein of 619 amino acids and a molecular mass of 70.5 kDa. Antibodies raised against a synthetic peptide, which corresponded to the C-terminus of the deduced sequence precipitated guanylate cyclase activity from guanylate cyclase-enriched preparations. |
| doi_str_mv | 10.1016/0014-5793(88)80539-8 |
| format | Article |
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The alignment of six different clones out of two bovine libraries yielded a total of 3.1 kb with a coding region of 1857 bases. The open reading frame encodes a protein of 619 amino acids and a molecular mass of 70.5 kDa. Antibodies raised against a synthetic peptide, which corresponded to the C-terminus of the deduced sequence precipitated guanylate cyclase activity from guanylate cyclase-enriched preparations.</description><subject>Amino Acid Sequence</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>cDNA sequence</subject><subject>Cloning, Molecular</subject><subject>DNA - genetics</subject><subject>Enzymes and enzyme inhibitors</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guanylate cyclase</subject><subject>Guanylate Cyclase - genetics</subject><subject>Lung - enzymology</subject><subject>Lyases</subject><subject>Macromolecular Substances</subject><subject>Molecular Sequence Data</subject><subject>Molecular Weight</subject><subject>Peptide antibody</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1u1DAURi0EKtPCG4DkBUJlEfBP4lxvKkHpAFKlbsracpwbMHiSYsdF8_bEnWiWwMry_Y4_24eQF5y95Yyrd4zxumpaLc8B3gBrpK7gEdlwaGUlawWPyeaIPCWnKf1gyx64PiEnQjPJWr4hN7ffkd5Fv7NxT9Mcs5tzRDoNdF6CltGfHy1Nucujn8u0m-79iDRNIXcB6bdsx32wM1K3d8EmfEaeDDYkfL6uZ-Tr9ur28nN1ffPpy-X768o1WkBlpUPUYugU9orJWghRMyWQNY0YALFzGlzXDSC1A2fbXkKLDHqtnbX9oOQZeX3ovYvTr4xpNjufHIZgR5xyMi3UWmsF_wR5wxoNNVvA-gC6OKUUcTCrFsOZKcJNsWmKTQNgHoSb0v9y7c_dDvvjodXwkr9ac5ucDUO0o_PpiClV7tcLtj1gv33A_X9dbbZXH0QJyhzgYVrec3EowsX-vcdokvM4Oux9RDebfvJ__9AfFoivfg</recordid><startdate>19881024</startdate><enddate>19881024</enddate><creator>Koesling, Doris</creator><creator>Herz, Joachim</creator><creator>Gausepohl, Heinrich</creator><creator>Niroomand, Feraydoon</creator><creator>Hinsch, Klaus-Dieter</creator><creator>Mülsch, Alexander</creator><creator>Böhme, Eycke</creator><creator>Schultz, Günter</creator><creator>Frank, Rainer</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19881024</creationdate><title>The primary structure of the 70 kDa subunit of bovine soluble guanylate cyclase</title><author>Koesling, Doris ; Herz, Joachim ; Gausepohl, Heinrich ; Niroomand, Feraydoon ; Hinsch, Klaus-Dieter ; Mülsch, Alexander ; Böhme, Eycke ; Schultz, Günter ; Frank, Rainer</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5928-a3cee92fb6ed60342224062e0552f8eebc98cbbf839c8ca7d387e08d99caadf63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Amino Acid Sequence</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>cDNA sequence</topic><topic>Cloning, Molecular</topic><topic>DNA - genetics</topic><topic>Enzymes and enzyme inhibitors</topic><topic>Fundamental and applied biological sciences. 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The alignment of six different clones out of two bovine libraries yielded a total of 3.1 kb with a coding region of 1857 bases. The open reading frame encodes a protein of 619 amino acids and a molecular mass of 70.5 kDa. Antibodies raised against a synthetic peptide, which corresponded to the C-terminus of the deduced sequence precipitated guanylate cyclase activity from guanylate cyclase-enriched preparations.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2903071</pmid><doi>10.1016/0014-5793(88)80539-8</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | FEBS letters, 1988-10, Vol.239 (1), p.29-34 |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Analytical, structural and metabolic biochemistry Animals Base Sequence Biological and medical sciences Cattle cDNA sequence Cloning, Molecular DNA - genetics Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Guanylate cyclase Guanylate Cyclase - genetics Lung - enzymology Lyases Macromolecular Substances Molecular Sequence Data Molecular Weight Peptide antibody |
| title | The primary structure of the 70 kDa subunit of bovine soluble guanylate cyclase |
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