Cortical versus medullary thymomas: A useful morphologic distinction?
We have tested the hypothesis that thymomas can be classified solely on the basis of epithelial cell morphology and that this distinction is prognostically useful. One hundred thymic epithelial tumors were classified according to the morphologic resem-blance to cortical or medullary thymic epitheliu...
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| Veröffentlicht in: | Human pathology 1988-11, Vol.19 (11), p.1335-1339 |
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| creator | Kornstein, Michael J. Curran, Walter J. Turrisi, Andrew T. Brooks, John J. |
| description | We have tested the hypothesis that thymomas can be classified solely on the basis of epithelial cell morphology and that this distinction is prognostically useful. One hundred thymic epithelial tumors were classified according to the morphologic resem-blance to cortical or medullary thymic epithelium and to the traditional classification (lymphocytic, epithelial, mixed, and spindled). Follow-up data was obtained on 78 patients. Fifty-eight percent of the tumors were invasive. Nineteen of the invasive tumors relapsed and none of the non-invasive tumors relapsed (
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| doi_str_mv | 10.1016/S0046-8177(88)80289-2 |
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P <.0001). Four of nine tumors with microscopic invasion through the capsule recurred. Statistical analysis showed no significant differences in relapse-free survival for any of the histologic categories. Ninety-four percent of the tumors studied were keratin positive and all were chromogranin negative. Carcinomebryonic antigen was negative for all but one cytologically malignant tumor; of the tumors 75% were epithelial membrane antigenpositive, 80% were Leu-7 positive, and 11% were neuron specific enolase positive. Seven of 12 tumors tested expressed HLA-DR. There was no correlation between immunoreactivity and classification. The morphologic conrtical/medullary distinction is conceptually attractive but appears clinically to be no more advan-tageous than the traditional classification.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/S0046-8177(88)80289-2</identifier><identifier>PMID: 3181952</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Biological and medical sciences ; classification ; Humans ; immunohistochemistry ; Medical sciences ; Middle Aged ; Pneumology ; thymoma ; Thymoma - pathology ; Thymus Neoplasms - pathology ; Tumors of the respiratory system and mediastinum</subject><ispartof>Human pathology, 1988-11, Vol.19 (11), p.1335-1339</ispartof><rights>1988 W.B. Saunders Company. All rights reserved</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-acd0579043e419cb8da3b96d48cb088f6623243ab61b16af93c252155183b43d3</citedby><cites>FETCH-LOGICAL-c389t-acd0579043e419cb8da3b96d48cb088f6623243ab61b16af93c252155183b43d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0046-8177(88)80289-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6721356$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3181952$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kornstein, Michael J.</creatorcontrib><creatorcontrib>Curran, Walter J.</creatorcontrib><creatorcontrib>Turrisi, Andrew T.</creatorcontrib><creatorcontrib>Brooks, John J.</creatorcontrib><title>Cortical versus medullary thymomas: A useful morphologic distinction?</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>We have tested the hypothesis that thymomas can be classified solely on the basis of epithelial cell morphology and that this distinction is prognostically useful. One hundred thymic epithelial tumors were classified according to the morphologic resem-blance to cortical or medullary thymic epithelium and to the traditional classification (lymphocytic, epithelial, mixed, and spindled). Follow-up data was obtained on 78 patients. Fifty-eight percent of the tumors were invasive. Nineteen of the invasive tumors relapsed and none of the non-invasive tumors relapsed (
P <.0001). Four of nine tumors with microscopic invasion through the capsule recurred. Statistical analysis showed no significant differences in relapse-free survival for any of the histologic categories. Ninety-four percent of the tumors studied were keratin positive and all were chromogranin negative. Carcinomebryonic antigen was negative for all but one cytologically malignant tumor; of the tumors 75% were epithelial membrane antigenpositive, 80% were Leu-7 positive, and 11% were neuron specific enolase positive. Seven of 12 tumors tested expressed HLA-DR. There was no correlation between immunoreactivity and classification. The morphologic conrtical/medullary distinction is conceptually attractive but appears clinically to be no more advan-tageous than the traditional classification.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>classification</subject><subject>Humans</subject><subject>immunohistochemistry</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>thymoma</subject><subject>Thymoma - pathology</subject><subject>Thymus Neoplasms - pathology</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKxDAUhoMoOl4eQehCRBfVXJr0xM0wDOMFBBfqOqRpqpG2GZNW8O2NTpmtq7M4338uH0KnBF8RTMT1M8aFyIGU5QXAJWAKMqc7aEY4ozkwSXfRbIscoMMYPzAmhBd8H-0zAkRyOkOrpQ-DM7rNvmyIY8w6W49tq8N3Nrx_d77T8SZbZGO0zdhmnQ_rd9_6N2ey2sXB9WZwvp8fo71Gt9GeTPUIvd6uXpb3-ePT3cNy8ZgbBnLItakxLyUumC2INBXUmlVS1AWYCgM0QlBGC6YrQSoidCOZoZwSzgmwqmA1O0Lnm7nr4D9HGwfVuWhsure3foyqhEKWvIQE8g1ogo8x2Eatg-vSV4pg9atP_elTv24UgPrTp2jKnU4LxiqZ2KYmX6l_NvV1TNKaoHvj4hYTJSWMi4TNN5hNMr6cDSoaZ3tjaxesGVTt3T-H_AA1wIvB</recordid><startdate>19881101</startdate><enddate>19881101</enddate><creator>Kornstein, Michael J.</creator><creator>Curran, Walter J.</creator><creator>Turrisi, Andrew T.</creator><creator>Brooks, John J.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19881101</creationdate><title>Cortical versus medullary thymomas: A useful morphologic distinction?</title><author>Kornstein, Michael J. ; Curran, Walter J. ; Turrisi, Andrew T. ; Brooks, John J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-acd0579043e419cb8da3b96d48cb088f6623243ab61b16af93c252155183b43d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>classification</topic><topic>Humans</topic><topic>immunohistochemistry</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pneumology</topic><topic>thymoma</topic><topic>Thymoma - pathology</topic><topic>Thymus Neoplasms - pathology</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kornstein, Michael J.</creatorcontrib><creatorcontrib>Curran, Walter J.</creatorcontrib><creatorcontrib>Turrisi, Andrew T.</creatorcontrib><creatorcontrib>Brooks, John J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kornstein, Michael J.</au><au>Curran, Walter J.</au><au>Turrisi, Andrew T.</au><au>Brooks, John J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cortical versus medullary thymomas: A useful morphologic distinction?</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>1988-11-01</date><risdate>1988</risdate><volume>19</volume><issue>11</issue><spage>1335</spage><epage>1339</epage><pages>1335-1339</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>We have tested the hypothesis that thymomas can be classified solely on the basis of epithelial cell morphology and that this distinction is prognostically useful. One hundred thymic epithelial tumors were classified according to the morphologic resem-blance to cortical or medullary thymic epithelium and to the traditional classification (lymphocytic, epithelial, mixed, and spindled). Follow-up data was obtained on 78 patients. Fifty-eight percent of the tumors were invasive. Nineteen of the invasive tumors relapsed and none of the non-invasive tumors relapsed (
P <.0001). Four of nine tumors with microscopic invasion through the capsule recurred. Statistical analysis showed no significant differences in relapse-free survival for any of the histologic categories. Ninety-four percent of the tumors studied were keratin positive and all were chromogranin negative. Carcinomebryonic antigen was negative for all but one cytologically malignant tumor; of the tumors 75% were epithelial membrane antigenpositive, 80% were Leu-7 positive, and 11% were neuron specific enolase positive. Seven of 12 tumors tested expressed HLA-DR. There was no correlation between immunoreactivity and classification. The morphologic conrtical/medullary distinction is conceptually attractive but appears clinically to be no more advan-tageous than the traditional classification.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3181952</pmid><doi>10.1016/S0046-8177(88)80289-2</doi><tpages>5</tpages></addata></record> |
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| language | eng |
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| subjects | Adult Aged Biological and medical sciences classification Humans immunohistochemistry Medical sciences Middle Aged Pneumology thymoma Thymoma - pathology Thymus Neoplasms - pathology Tumors of the respiratory system and mediastinum |
| title | Cortical versus medullary thymomas: A useful morphologic distinction? |
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