Neuronal Gene Expression in the Waking State: A Role for the Locus Coeruleus

Several transcription factors are expressed at higher levels in the waking than in the sleeping brain. In experiments with rats, the locus coeruleus, a noradrenergic nucleus with diffuse projections, was found to regulates such expression. In brain regions depleted of noradrenergic innervation, amou...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1996-11, Vol.274 (5290), p.1211-1215
Hauptverfasser:	Cirelli, Chiara, Pompeiano, Maria, Tononi, Giulio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic Fibers - drug effects Adrenergic Fibers - physiology Animals Behavioral neuroscience Benzylamines - pharmacology Biological and medical sciences Brain Brain - metabolism Cerebral Cortex - metabolism Cyclic AMP Response Element-Binding Protein - metabolism DNA-Binding Proteins - genetics Early Growth Response Protein 1 Electroencephalography Eye Movements Fear of Success Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes Genes, fos Genes, Immediate-Early Hippocampus - metabolism Immediate-Early Proteins Innervation Lesions Locus Coeruleus - physiology Logical Thinking Motor Reactions Neurons Neurons - metabolism Norepinephrine - metabolism Oxidopamine - pharmacology Phosphorylation Rapid eye movement sleep Rats Rodents Sleep Sleep Deprivation Sleep. Vigilance Sympathectomy, Chemical Transcription Factors - genetics Vertebrates: nervous system and sense organs Wakefulness
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