Neuronal Gene Expression in the Waking State: A Role for the Locus Coeruleus
Several transcription factors are expressed at higher levels in the waking than in the sleeping brain. In experiments with rats, the locus coeruleus, a noradrenergic nucleus with diffuse projections, was found to regulates such expression. In brain regions depleted of noradrenergic innervation, amou...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1996-11, Vol.274 (5290), p.1211-1215 |
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| creator | Cirelli, Chiara Pompeiano, Maria Tononi, Giulio |
| description | Several transcription factors are expressed at higher levels in the waking than in the sleeping brain. In experiments with rats, the locus coeruleus, a noradrenergic nucleus with diffuse projections, was found to regulates such expression. In brain regions depleted of noradrenergic innervation, amounts of c-Fos and nerve growth factor-induced A after waking were as low as after sleep. Phosphorylation of cyclic adenosine monophosphate response element-binding protein was also reduced. In contrast, electroencephalographic activity was unchanged. The reduced activity of locus coeruleus neurons may explain why the induction of certain transcription factors, with potential effects on plasticity and learning, does not occur during sleep. |
| doi_str_mv | 10.1126/science.274.5290.1211 |
| format | Article |
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In experiments with rats, the locus coeruleus, a noradrenergic nucleus with diffuse projections, was found to regulates such expression. In brain regions depleted of noradrenergic innervation, amounts of c-Fos and nerve growth factor-induced A after waking were as low as after sleep. Phosphorylation of cyclic adenosine monophosphate response element-binding protein was also reduced. In contrast, electroencephalographic activity was unchanged. The reduced activity of locus coeruleus neurons may explain why the induction of certain transcription factors, with potential effects on plasticity and learning, does not occur during sleep.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.274.5290.1211</identifier><identifier>PMID: 8895474</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Adrenergic Fibers - drug effects ; Adrenergic Fibers - physiology ; Animals ; Behavioral neuroscience ; Benzylamines - pharmacology ; Biological and medical sciences ; Brain ; Brain - metabolism ; Cerebral Cortex - metabolism ; Cyclic AMP Response Element-Binding Protein - metabolism ; DNA-Binding Proteins - genetics ; Early Growth Response Protein 1 ; Electroencephalography ; Eye Movements ; Fear of Success ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; Genes ; Genes, fos ; Genes, Immediate-Early ; Hippocampus - metabolism ; Immediate-Early Proteins ; Innervation ; Lesions ; Locus Coeruleus - physiology ; Logical Thinking ; Motor Reactions ; Neurons ; Neurons - metabolism ; Norepinephrine - metabolism ; Oxidopamine - pharmacology ; Phosphorylation ; Rapid eye movement sleep ; Rats ; Rodents ; Sleep ; Sleep Deprivation ; Sleep. Vigilance ; Sympathectomy, Chemical ; Transcription Factors - genetics ; Vertebrates: nervous system and sense organs ; Wakefulness</subject><ispartof>Science (American Association for the Advancement of Science), 1996-11, Vol.274 (5290), p.1211-1215</ispartof><rights>Copyright 1996 American Association for the Advancement of Science</rights><rights>1997 INIST-CNRS</rights><rights>Copyright American Association for the Advancement of Science Nov 15, 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-61d70c61800dcf87dd8a364131f93c287a3962b54986cba12ebfaccd35e527de3</citedby><cites>FETCH-LOGICAL-c475t-61d70c61800dcf87dd8a364131f93c287a3962b54986cba12ebfaccd35e527de3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2891599$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2891599$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,2884,2885,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2490416$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8895474$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cirelli, Chiara</creatorcontrib><creatorcontrib>Pompeiano, Maria</creatorcontrib><creatorcontrib>Tononi, Giulio</creatorcontrib><title>Neuronal Gene Expression in the Waking State: A Role for the Locus Coeruleus</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Several transcription factors are expressed at higher levels in the waking than in the sleeping brain. In experiments with rats, the locus coeruleus, a noradrenergic nucleus with diffuse projections, was found to regulates such expression. In brain regions depleted of noradrenergic innervation, amounts of c-Fos and nerve growth factor-induced A after waking were as low as after sleep. Phosphorylation of cyclic adenosine monophosphate response element-binding protein was also reduced. In contrast, electroencephalographic activity was unchanged. The reduced activity of locus coeruleus neurons may explain why the induction of certain transcription factors, with potential effects on plasticity and learning, does not occur during sleep.</description><subject>Adrenergic Fibers - drug effects</subject><subject>Adrenergic Fibers - physiology</subject><subject>Animals</subject><subject>Behavioral neuroscience</subject><subject>Benzylamines - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Brain</subject><subject>Brain - metabolism</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cyclic AMP Response Element-Binding Protein - metabolism</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Early Growth Response Protein 1</subject><subject>Electroencephalography</subject><subject>Eye Movements</subject><subject>Fear of Success</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation</subject><subject>Genes</subject><subject>Genes, fos</subject><subject>Genes, Immediate-Early</subject><subject>Hippocampus - metabolism</subject><subject>Immediate-Early Proteins</subject><subject>Innervation</subject><subject>Lesions</subject><subject>Locus Coeruleus - physiology</subject><subject>Logical Thinking</subject><subject>Motor Reactions</subject><subject>Neurons</subject><subject>Neurons - metabolism</subject><subject>Norepinephrine - metabolism</subject><subject>Oxidopamine - pharmacology</subject><subject>Phosphorylation</subject><subject>Rapid eye movement sleep</subject><subject>Rats</subject><subject>Rodents</subject><subject>Sleep</subject><subject>Sleep Deprivation</subject><subject>Sleep. 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in the Waking State: A Role for the Locus Coeruleus</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1996-11-15</date><risdate>1996</risdate><volume>274</volume><issue>5290</issue><spage>1211</spage><epage>1215</epage><pages>1211-1215</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Several transcription factors are expressed at higher levels in the waking than in the sleeping brain. In experiments with rats, the locus coeruleus, a noradrenergic nucleus with diffuse projections, was found to regulates such expression. In brain regions depleted of noradrenergic innervation, amounts of c-Fos and nerve growth factor-induced A after waking were as low as after sleep. Phosphorylation of cyclic adenosine monophosphate response element-binding protein was also reduced. In contrast, electroencephalographic activity was unchanged. The reduced activity of locus coeruleus neurons may explain why the induction of certain transcription factors, with potential effects on plasticity and learning, does not occur during sleep.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>8895474</pmid><doi>10.1126/science.274.5290.1211</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1996-11, Vol.274 (5290), p.1211-1215 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78497449 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Adrenergic Fibers - drug effects Adrenergic Fibers - physiology Animals Behavioral neuroscience Benzylamines - pharmacology Biological and medical sciences Brain Brain - metabolism Cerebral Cortex - metabolism Cyclic AMP Response Element-Binding Protein - metabolism DNA-Binding Proteins - genetics Early Growth Response Protein 1 Electroencephalography Eye Movements Fear of Success Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes Genes, fos Genes, Immediate-Early Hippocampus - metabolism Immediate-Early Proteins Innervation Lesions Locus Coeruleus - physiology Logical Thinking Motor Reactions Neurons Neurons - metabolism Norepinephrine - metabolism Oxidopamine - pharmacology Phosphorylation Rapid eye movement sleep Rats Rodents Sleep Sleep Deprivation Sleep. Vigilance Sympathectomy, Chemical Transcription Factors - genetics Vertebrates: nervous system and sense organs Wakefulness |
| title | Neuronal Gene Expression in the Waking State: A Role for the Locus Coeruleus |
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