Effects of age on levels of cysteine, glutathione and related enzyme activities in livers of mice and rats and an attempt to replenish hepatic glutathione level of mouse with cysteine derivatives

There was a large statistically significant decrease in the hepatic level of cysteine and glutathione (GSH) in 24 month-old mice compared to young mice, while, cystine and glutathione disulfide (GSSG) contents in the liver did not differ between young and old mice. Activities of cystathionine γ-lyas...

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Veröffentlicht in:	Mechanisms of ageing and development 1996-09, Vol.90 (3), p.195-207
Hauptverfasser:	Nakata, Kunihiko, Kawase, Michi, Ogino, Shinya, Kinoshita, Chieko, Murata, Hideaki, Sakaue, Takahiro, Ogata, Kazumi, Ohmori, Shinji
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Age Aging - metabolism Animals Cystathionase Cystathionine beta-Synthase - metabolism Cystathionine gamma-Lyase - metabolism Cystathionine-synthase Cysteine Cysteine - analogs & derivatives Cysteine - metabolism Cysteine - pharmacology Cysteine derivatives Cystine - metabolism Female Glutathione Glutathione - analogs & derivatives Glutathione - metabolism Glutathione Disulfide Liver - drug effects Liver - enzymology Liver - metabolism Male Maleates - pharmacology Mice Rats Rats, Inbred F344 Species Specificity
Online-Zugang:	Volltext
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