Effects of age on levels of cysteine, glutathione and related enzyme activities in livers of mice and rats and an attempt to replenish hepatic glutathione level of mouse with cysteine derivatives
There was a large statistically significant decrease in the hepatic level of cysteine and glutathione (GSH) in 24 month-old mice compared to young mice, while, cystine and glutathione disulfide (GSSG) contents in the liver did not differ between young and old mice. Activities of cystathionine γ-lyas...
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| Veröffentlicht in: | Mechanisms of ageing and development 1996-09, Vol.90 (3), p.195-207 |
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| container_title | Mechanisms of ageing and development |
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| creator | Nakata, Kunihiko Kawase, Michi Ogino, Shinya Kinoshita, Chieko Murata, Hideaki Sakaue, Takahiro Ogata, Kazumi Ohmori, Shinji |
| description | There was a large statistically significant decrease in the hepatic level of cysteine and glutathione (GSH) in 24 month-old mice compared to young mice, while, cystine and glutathione disulfide (GSSG) contents in the liver did not differ between young and old mice. Activities of cystathionine γ-lyase and β-synthase in mouse live of the 24 month-old group were significantly decreased. In rats, the hepatic levels of cysteine, cystine, GSH and GSSG exhibited no statistically significant change during aging to 30 month. As the rats matured, total hepatic activities of both cystathionine γ-lyase and β-synthase increased with maximum levels at 24 months of age and decreased to the same level found in 5 week old for the former and to 22% of that in 5 week old for the latter. Intraperitoneal administration of diethyl maleate to mice led to depletion of hepatic GSH. When
N-acetylcysteine and a thiazolidine derivative were intravenously injected after diethyl maleate administration, the hepatic GSH level of mice was restored to the normal level. |
| doi_str_mv | 10.1016/0047-6374(96)01771-X |
| format | Article |
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N-acetylcysteine and a thiazolidine derivative were intravenously injected after diethyl maleate administration, the hepatic GSH level of mice was restored to the normal level.</description><subject>Acetylcysteine - pharmacology</subject><subject>Age</subject><subject>Aging - metabolism</subject><subject>Animals</subject><subject>Cystathionase</subject><subject>Cystathionine beta-Synthase - metabolism</subject><subject>Cystathionine gamma-Lyase - metabolism</subject><subject>Cystathionine-synthase</subject><subject>Cysteine</subject><subject>Cysteine - analogs & derivatives</subject><subject>Cysteine - metabolism</subject><subject>Cysteine - pharmacology</subject><subject>Cysteine derivatives</subject><subject>Cystine - metabolism</subject><subject>Female</subject><subject>Glutathione</subject><subject>Glutathione - analogs & derivatives</subject><subject>Glutathione - metabolism</subject><subject>Glutathione Disulfide</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Maleates - pharmacology</subject><subject>Mice</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Species Specificity</subject><issn>0047-6374</issn><issn>1872-6216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd1q3DAQhUVpSTdp36AFXZUU6layvJJ9Uygh_YFAb1rInRhL46yKLbuS1mHzenmxyrvLQm4KAkkz55wZ-Ah5w9lHzrj8xFilCilUddnI94wrxYvbZ2TFa1UWsuTyOVmdJC_JeYx_GGO8KuUZOavrphZcrMjjddehSZGOHYU7pKOnPc7Y7wtmFxM6jx_oXb9NkDZu9EjBWxqwh4SWon_YDblkkptdchipywFuxrAPGJw56iGPWB7gKaSEw5RoGnPM1KN3cUM3OEFy5smg_SL7mHEbkd67tDmtRC0GN2fLjPEVedFBH_H18b4gv79e_7r6Xtz8_Pbj6stNYcRapUKVnDNRtxWsW8AaqtZyYKJtrZTGNJjbTVkilMyW1nT5CEBQyKrOCujW4oK8O-ROYfy7xZj04KLBvgePeUOt6qqRgldZWB2EJowxBuz0FNwAYac50ws7vYDRCxjd5M_CTt9m29tj_rYd0J5MR1i5__nQz3hwdhh0NA69QetCZqjt6P4_4B8EZ68O</recordid><startdate>19960930</startdate><enddate>19960930</enddate><creator>Nakata, Kunihiko</creator><creator>Kawase, Michi</creator><creator>Ogino, Shinya</creator><creator>Kinoshita, Chieko</creator><creator>Murata, Hideaki</creator><creator>Sakaue, Takahiro</creator><creator>Ogata, Kazumi</creator><creator>Ohmori, Shinji</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960930</creationdate><title>Effects of age on levels of cysteine, glutathione and related enzyme activities in livers of mice and rats and an attempt to replenish hepatic glutathione level of mouse with cysteine derivatives</title><author>Nakata, Kunihiko ; Kawase, Michi ; Ogino, Shinya ; Kinoshita, Chieko ; Murata, Hideaki ; Sakaue, Takahiro ; Ogata, Kazumi ; Ohmori, Shinji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-7211038b4a5bae8a4bd1a03bbd66cc9e211922ea20d2dcfdcf3aea7e04fd3af53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Acetylcysteine - pharmacology</topic><topic>Age</topic><topic>Aging - metabolism</topic><topic>Animals</topic><topic>Cystathionase</topic><topic>Cystathionine beta-Synthase - metabolism</topic><topic>Cystathionine gamma-Lyase - metabolism</topic><topic>Cystathionine-synthase</topic><topic>Cysteine</topic><topic>Cysteine - analogs & derivatives</topic><topic>Cysteine - metabolism</topic><topic>Cysteine - pharmacology</topic><topic>Cysteine derivatives</topic><topic>Cystine - metabolism</topic><topic>Female</topic><topic>Glutathione</topic><topic>Glutathione - analogs & derivatives</topic><topic>Glutathione - metabolism</topic><topic>Glutathione Disulfide</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Maleates - pharmacology</topic><topic>Mice</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Species Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakata, Kunihiko</creatorcontrib><creatorcontrib>Kawase, Michi</creatorcontrib><creatorcontrib>Ogino, Shinya</creatorcontrib><creatorcontrib>Kinoshita, Chieko</creatorcontrib><creatorcontrib>Murata, Hideaki</creatorcontrib><creatorcontrib>Sakaue, Takahiro</creatorcontrib><creatorcontrib>Ogata, Kazumi</creatorcontrib><creatorcontrib>Ohmori, Shinji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Mechanisms of ageing and development</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakata, Kunihiko</au><au>Kawase, Michi</au><au>Ogino, Shinya</au><au>Kinoshita, Chieko</au><au>Murata, Hideaki</au><au>Sakaue, Takahiro</au><au>Ogata, Kazumi</au><au>Ohmori, Shinji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of age on levels of cysteine, glutathione and related enzyme activities in livers of mice and rats and an attempt to replenish hepatic glutathione level of mouse with cysteine derivatives</atitle><jtitle>Mechanisms of ageing and development</jtitle><addtitle>Mech Ageing Dev</addtitle><date>1996-09-30</date><risdate>1996</risdate><volume>90</volume><issue>3</issue><spage>195</spage><epage>207</epage><pages>195-207</pages><issn>0047-6374</issn><eissn>1872-6216</eissn><abstract>There was a large statistically significant decrease in the hepatic level of cysteine and glutathione (GSH) in 24 month-old mice compared to young mice, while, cystine and glutathione disulfide (GSSG) contents in the liver did not differ between young and old mice. Activities of cystathionine γ-lyase and β-synthase in mouse live of the 24 month-old group were significantly decreased. In rats, the hepatic levels of cysteine, cystine, GSH and GSSG exhibited no statistically significant change during aging to 30 month. As the rats matured, total hepatic activities of both cystathionine γ-lyase and β-synthase increased with maximum levels at 24 months of age and decreased to the same level found in 5 week old for the former and to 22% of that in 5 week old for the latter. Intraperitoneal administration of diethyl maleate to mice led to depletion of hepatic GSH. When
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| subjects | Acetylcysteine - pharmacology Age Aging - metabolism Animals Cystathionase Cystathionine beta-Synthase - metabolism Cystathionine gamma-Lyase - metabolism Cystathionine-synthase Cysteine Cysteine - analogs & derivatives Cysteine - metabolism Cysteine - pharmacology Cysteine derivatives Cystine - metabolism Female Glutathione Glutathione - analogs & derivatives Glutathione - metabolism Glutathione Disulfide Liver - drug effects Liver - enzymology Liver - metabolism Male Maleates - pharmacology Mice Rats Rats, Inbred F344 Species Specificity |
| title | Effects of age on levels of cysteine, glutathione and related enzyme activities in livers of mice and rats and an attempt to replenish hepatic glutathione level of mouse with cysteine derivatives |
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