Insulin response of a hybrid amylase/CAT gene in transgenic mice

Expression of an amylase/CAT hybrid gene was analyzed in transgenic mice. The amylase promoter was derived from a pancreatic amylase gene whose expression is repressed in diabetic animals. Pancreas-specific expression of the amylase/chloramphenicol acetyl-transferase (CAT) construct was observed in...

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Veröffentlicht in:	The Journal of biological chemistry 1988-11, Vol.263 (32), p.16519-16522
Hauptverfasser:	Osborn, L, Rosenberg, M P, Keller, S A, Ting, C N, Meisler, M H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amylases - genetics Animals Base Sequence Biological and medical sciences Biotechnology Cell Line Chloramphenicol O-Acetyltransferase - genetics Diabetes Mellitus, Experimental - genetics Fundamental and applied biological sciences. Psychology Gene expression Genetic engineering Genetic technics Insulin - metabolism Methods. Procedures. Technologies Mice Mice, Transgenic Molecular and cellular biology Molecular genetics Molecular Sequence Data Nucleotide Mapping Pancreas - enzymology Promoter Regions, Genetic Transcription, Genetic Vectors (cloning, transfer, expression). Insertion sequences and transposons
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