Effects of butyrate on epidermal growth factor receptor binding, morphology, and DNA synthesis in cultured rat hepatocytes

We have examined the effect of butyrate on morphology, DNA synthesis, and epidermal growth factor (EGF) receptor binding in primary cultures of rat hepatocytes. Butyrate added 2 h after plating retarded the flattening and maintained the polyhedral shape of the hepatocytes in culture. Both insulin- a...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1988-11, Vol.48 (22), p.6560-6564
Hauptverfasser:	GLADHAUG, I. P, REFSNES, M, SAND, T.-E, CHRISTOFFERSEN, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences butyrate Butyrates - pharmacology Butyric Acid Cell physiology Cells, Cultured DNA - biosynthesis epidermal growth factor Epidermal Growth Factor - metabolism Fundamental and applied biological sciences. Psychology Liver - drug effects Liver - metabolism Liver - pathology Male Molecular and cellular biology Rats Rats, Inbred Strains Receptor, Epidermal Growth Factor - analysis Receptor, Epidermal Growth Factor - drug effects Receptor, Epidermal Growth Factor - metabolism Responses to growth factors, tumor promotors, other factors
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