Inhibition of the aldosterone response to sodium depletion in man by stimulation of dopamine DA2 receptors
In this study we have investigated the effect of co-dergocrine, a selective DA2-agonist, on plasma aldosterone concentrations (PAC) in twelve patients with essential hypertension both in basal conditions and during sodium depletion. Sodium depletion resulted in an increase of PAC from 38 (13) pg/ml...
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| Veröffentlicht in: | European journal of clinical pharmacology 1988-01, Vol.35 (3), p.323-326 |
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| container_end_page | 326 |
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| container_issue | 3 |
| container_start_page | 323 |
| container_title | European journal of clinical pharmacology |
| container_volume | 35 |
| creator | LOMBARDI, C MISSALE, C DE COTIIS, R SPEDINI, C PIZZOCCOLO, G MEMO, M ALBERTINI, A SPANO, P. F |
| description | In this study we have investigated the effect of co-dergocrine, a selective DA2-agonist, on plasma aldosterone concentrations (PAC) in twelve patients with essential hypertension both in basal conditions and during sodium depletion. Sodium depletion resulted in an increase of PAC from 38 (13) pg/ml to 297 (21) pg/ml. The PAC response to sodium depletion was reduced to 155 (29) pg/ml by co-dergocrine. No significant PAC changes were found in patients maintained on a normal sodium intake. In addition the drug did not significantly modify plasma renin activity (PRA) in either experimental group. These results suggest that the dopaminergic inhibition of aldosterone secretion in man is mediated by DA2 receptors in the adrenal cortex. |
| doi_str_mv | 10.1007/BF00558273 |
| format | Article |
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These results suggest that the dopaminergic inhibition of aldosterone secretion in man is mediated by DA2 receptors in the adrenal cortex.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/BF00558273</identifier><identifier>PMID: 2972550</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Aged ; Aldosterone - blood ; Biological and medical sciences ; Catecholaminergic system ; Dihydroergotoxine - pharmacology ; Female ; Humans ; Hypertension - blood ; Male ; Medical sciences ; Middle Aged ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; Pharmacology. 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F</creatorcontrib><title>Inhibition of the aldosterone response to sodium depletion in man by stimulation of dopamine DA2 receptors</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>In this study we have investigated the effect of co-dergocrine, a selective DA2-agonist, on plasma aldosterone concentrations (PAC) in twelve patients with essential hypertension both in basal conditions and during sodium depletion. Sodium depletion resulted in an increase of PAC from 38 (13) pg/ml to 297 (21) pg/ml. The PAC response to sodium depletion was reduced to 155 (29) pg/ml by co-dergocrine. No significant PAC changes were found in patients maintained on a normal sodium intake. In addition the drug did not significantly modify plasma renin activity (PRA) in either experimental group. These results suggest that the dopaminergic inhibition of aldosterone secretion in man is mediated by DA2 receptors in the adrenal cortex.</description><subject>Aged</subject><subject>Aldosterone - blood</subject><subject>Biological and medical sciences</subject><subject>Catecholaminergic system</subject><subject>Dihydroergotoxine - pharmacology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>Pharmacology. Drug treatments</subject><subject>Receptors, Dopamine - drug effects</subject><subject>Receptors, Dopamine - metabolism</subject><subject>Receptors, Dopamine D2</subject><subject>Renin - blood</subject><subject>Sodium - metabolism</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkLtOxTAQRC0EgsujoUdygSiQAru2E8clb5CQaKCOnGQtjJI42EnB3xPgAttsMWdOMYwdIpwhgD6_vAXI81JoucFWqKTIEBRushWAxKwwGnbYbkpvAJgbkNtsWxgt8hxW7O1hePW1n3wYeHB8eiVuuzakiWIYiEdKYxgS8SnwFFo_97ylsaNv3g-8twOvP3iafD939tfShtH2fqlfX4hF0dA4hZj22ZazXaKD9d9jL7c3z1f32ePT3cPVxWPWSMQps7auy9aaGoumwBxt6YRUqtAFSdNI1wqjanRkwC2AqEETLtcWQqkS0ck9dvLjHWN4nylNVe9TQ11nBwpzqnSpDCowC3j6AzYxpBTJVWP0vY0fFUL1NWz1P-wCH62tc91T-4eul1zy43VuU2M7F-3Q-PSHaSykKbX8BDaGf9c</recordid><startdate>19880101</startdate><enddate>19880101</enddate><creator>LOMBARDI, C</creator><creator>MISSALE, C</creator><creator>DE COTIIS, R</creator><creator>SPEDINI, C</creator><creator>PIZZOCCOLO, G</creator><creator>MEMO, M</creator><creator>ALBERTINI, A</creator><creator>SPANO, P. 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| fulltext | fulltext |
| identifier | ISSN: 0031-6970 |
| ispartof | European journal of clinical pharmacology, 1988-01, Vol.35 (3), p.323-326 |
| issn | 0031-6970 1432-1041 |
| language | eng |
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| subjects | Aged Aldosterone - blood Biological and medical sciences Catecholaminergic system Dihydroergotoxine - pharmacology Female Humans Hypertension - blood Male Medical sciences Middle Aged Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Receptors, Dopamine - drug effects Receptors, Dopamine - metabolism Receptors, Dopamine D2 Renin - blood Sodium - metabolism |
| title | Inhibition of the aldosterone response to sodium depletion in man by stimulation of dopamine DA2 receptors |
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