Pharmacokinetically guided melatonin scheduling in rats with circadian system suppression

To obtain a pharmacologic effect of melatonin in rats kept under prolonged continuous light exposure, conditions known to produce functional suppression of the circadian system, mimicking of the physiologic 24-h pattern of melatonin secretion, a hormonal signal of darkness exposure may be needed. Th...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of pharmacology 1996-09, Vol.312 (2), p.171-178
Hauptverfasser:	Deprés-Brummer, Petra, Metzger, Gérard, Morin, Didier, Urien, Saïk, Touitou, Yvan, Tillement, Jean-Paul, Claustrat, Bruno, Lévi, Francis
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Sulfatoxymelatonin Animals Biological and medical sciences Blood Proteins - metabolism Body Temperature Regulation Circadian Rhythm Continuous light Drug Administration Schedule Hormones. Endocrine system Intravenous Male Medical sciences Melatonin Melatonin - administration & dosage Melatonin - analogs & derivatives Melatonin - metabolism Melatonin - pharmacokinetics Melatonin - urine Motor Activity - drug effects Pharmacokinetics Pharmacology. Drug treatments Protein Binding Rats Rats, Sprague-Dawley
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!