Efficacy Of High-Titer Live Attenuated Varicella Vaccine In Healthy Young Children
The efficacy of a high-titer, reformulated varicella vaccine was studied in 513 10- to 30-monthold children. Vaccinees were randomly allocated to 5 groups to receive one of two lots of an original high-titer vaccine, one of two lots of a partially heat-inactivated vaccine, or placebo. Both vaccines...
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| Veröffentlicht in: | The Journal of infectious diseases 1996-11, Vol.174 (Supplement-3), p.S330-S334 |
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| container_issue | Supplement-3 |
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| container_title | The Journal of infectious diseases |
| container_volume | 174 |
| creator | Varis, Tiina Vesikari, Timo |
| description | The efficacy of a high-titer, reformulated varicella vaccine was studied in 513 10- to 30-monthold children. Vaccinees were randomly allocated to 5 groups to receive one of two lots of an original high-titer vaccine, one of two lots of a partially heat-inactivated vaccine, or placebo. Both vaccines were well tolerated. Seroconversion was detected in 100%and 99% of children immunized with the high- and low-titer vaccines, respectively. Sixty-five cases of serologically confirmed varicella-like disease were discovered during follow-up (mean, 29.3 months): 5 in the high-titer vaccine group, 19 in the low-titer vaccine group, and 41 in the placebo group (P≤?.005 for each difference). Thus, the protective efficacy of live attenuated varicella vaccine is dependent on vaccine titer. High-titer varicella vaccine induces excellent protection in healthy young children. |
| doi_str_mv | 10.1093/infdis/174.Supplement_3.S330 |
| format | Article |
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| ispartof | The Journal of infectious diseases, 1996-11, Vol.174 (Supplement-3), p.S330-S334 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Antibodies Antibodies, Viral - blood Blood Chickenpox Chickenpox vaccine Chickenpox Vaccine - adverse effects Chickenpox Vaccine - immunology Child, Preschool Children Double-Blind Method Female Herpesvirus 3, Human - immunology Humans Immunity Immunization Infant Male Pediatrics Placebos Transcriptional regulatory elements Vaccination Vaccines, Attenuated - immunology |
| title | Efficacy Of High-Titer Live Attenuated Varicella Vaccine In Healthy Young Children |
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