Age-dependent decrease in embryo implantation rate after in vitro fertilization
To investigate the relation between the implantation rate per embryo after replacement in IVF-ET in relation to female age. Retrospective study using linear and biphasic models in a multivariate analysis. Academic tertiary care institution. In vitro fertilization-ET and determination of gestational...
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| Veröffentlicht in: | Fertility and sterility 1996-11, Vol.66 (5), p.769-775 |
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| container_title | Fertility and sterility |
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| creator | van Kooij, Roelof J. Looman, Caspar W.N. Habbema, Johannes D.F. Dorland, Marinus te Velde, Egbert R. |
| description | To investigate the relation between the implantation rate per embryo after replacement in IVF-ET in relation to female age.
Retrospective study using linear and biphasic models in a multivariate analysis.
Academic tertiary care institution.
In vitro fertilization-ET and determination of gestational sacs at 6 to 7 weeks of pregnancy by ultrasound.
Implantation rate as defined by the number of gestational sacs per embryo replaced.
Woman’s age and embryo morphology were strongly related to the implantation rate; indication for IVF-ET and cycle rank number also were related significantly but less strongly. A linear model was built describing the decrease in implantation rate with age, resulting in a decrease of approximately 7%. A biphasic model was tested also and performed significantly better, resulting in a yearly decrease of >20% after 37 years of age.
The most important independent factors related to the ability of embryos to implant are female age and embryo morphology. The best way to describe the relation with female age is a biphasic model with a discontinuity at approximately 37 years of age. |
| doi_str_mv | 10.1016/S0015-0282(16)58634-8 |
| format | Article |
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Retrospective study using linear and biphasic models in a multivariate analysis.
Academic tertiary care institution.
In vitro fertilization-ET and determination of gestational sacs at 6 to 7 weeks of pregnancy by ultrasound.
Implantation rate as defined by the number of gestational sacs per embryo replaced.
Woman’s age and embryo morphology were strongly related to the implantation rate; indication for IVF-ET and cycle rank number also were related significantly but less strongly. A linear model was built describing the decrease in implantation rate with age, resulting in a decrease of approximately 7%. A biphasic model was tested also and performed significantly better, resulting in a yearly decrease of >20% after 37 years of age.
The most important independent factors related to the ability of embryos to implant are female age and embryo morphology. The best way to describe the relation with female age is a biphasic model with a discontinuity at approximately 37 years of age.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(16)58634-8</identifier><identifier>PMID: 8893683</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aging ; Biological and medical sciences ; Birth control ; Embryo Implantation - physiology ; embryo morphology ; Embryo Transfer ; Female ; female age ; Fertilization in Vitro ; Gynecology. Andrology. Obstetrics ; Humans ; Implantation rate ; in vitro fertilization ; Infertility - etiology ; Infertility - therapy ; Male ; Medical sciences ; Multivariate Analysis ; Pregnancy ; Sterility. Assisted procreation</subject><ispartof>Fertility and sterility, 1996-11, Vol.66 (5), p.769-775</ispartof><rights>1996 American Society for Reproductive Medicine</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-421f07591b5cfe258f20a683233dd5310069c9d2485dfd827eae5c220ddd779a3</citedby><cites>FETCH-LOGICAL-c389t-421f07591b5cfe258f20a683233dd5310069c9d2485dfd827eae5c220ddd779a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0015-0282(16)58634-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3261051$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8893683$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Kooij, Roelof J.</creatorcontrib><creatorcontrib>Looman, Caspar W.N.</creatorcontrib><creatorcontrib>Habbema, Johannes D.F.</creatorcontrib><creatorcontrib>Dorland, Marinus</creatorcontrib><creatorcontrib>te Velde, Egbert R.</creatorcontrib><title>Age-dependent decrease in embryo implantation rate after in vitro fertilization</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>To investigate the relation between the implantation rate per embryo after replacement in IVF-ET in relation to female age.
Retrospective study using linear and biphasic models in a multivariate analysis.
Academic tertiary care institution.
In vitro fertilization-ET and determination of gestational sacs at 6 to 7 weeks of pregnancy by ultrasound.
Implantation rate as defined by the number of gestational sacs per embryo replaced.
Woman’s age and embryo morphology were strongly related to the implantation rate; indication for IVF-ET and cycle rank number also were related significantly but less strongly. A linear model was built describing the decrease in implantation rate with age, resulting in a decrease of approximately 7%. A biphasic model was tested also and performed significantly better, resulting in a yearly decrease of >20% after 37 years of age.
The most important independent factors related to the ability of embryos to implant are female age and embryo morphology. The best way to describe the relation with female age is a biphasic model with a discontinuity at approximately 37 years of age.</description><subject>Aging</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Embryo Implantation - physiology</subject><subject>embryo morphology</subject><subject>Embryo Transfer</subject><subject>Female</subject><subject>female age</subject><subject>Fertilization in Vitro</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Implantation rate</subject><subject>in vitro fertilization</subject><subject>Infertility - etiology</subject><subject>Infertility - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Pregnancy</subject><subject>Sterility. Assisted procreation</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotVZ_QmEPInpYzcdmN3uSUvyCQg_qOaTJRCL7UZO0UH-9u-3Sq6dhmGdmXh6EpgTfE0zyh3eMCU8xFfSW5Hdc5CxLxQkaE87zlOecnaLxETlHFyF8Y4xzUtARGglRslywMVrOviA1sIbGQBMTA9qDCpC4JoF65Xdt4up1pZqoomubxKsIibIRfE9sXfRtYsFHV7nfPXGJzqyqAlwNdYI-n58-5q_pYvnyNp8tUs1EGdOMEosLXpIV1xYoF5Zi1QWijBnDGemClro0NBPcWCNoAQq4phQbY4qiVGyCbg5317792UCIsnZBQ9VFhXYTZCEyUZaF6EB-ALVvQ_Bg5dq7WvmdJFj2IuVepOwtya7bi5T93nR4sFnVYI5bg7lufj3MVdCqsl412oUjxmhOMCcd9njAoJOxdeBl0A4aDcZ50FGa1v0T5A9ou49Z</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>van Kooij, Roelof J.</creator><creator>Looman, Caspar W.N.</creator><creator>Habbema, Johannes D.F.</creator><creator>Dorland, Marinus</creator><creator>te Velde, Egbert R.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19961101</creationdate><title>Age-dependent decrease in embryo implantation rate after in vitro fertilization</title><author>van Kooij, Roelof J. ; Looman, Caspar W.N. ; Habbema, Johannes D.F. ; Dorland, Marinus ; te Velde, Egbert R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-421f07591b5cfe258f20a683233dd5310069c9d2485dfd827eae5c220ddd779a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Aging</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Embryo Implantation - physiology</topic><topic>embryo morphology</topic><topic>Embryo Transfer</topic><topic>Female</topic><topic>female age</topic><topic>Fertilization in Vitro</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Implantation rate</topic><topic>in vitro fertilization</topic><topic>Infertility - etiology</topic><topic>Infertility - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Pregnancy</topic><topic>Sterility. Assisted procreation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Kooij, Roelof J.</creatorcontrib><creatorcontrib>Looman, Caspar W.N.</creatorcontrib><creatorcontrib>Habbema, Johannes D.F.</creatorcontrib><creatorcontrib>Dorland, Marinus</creatorcontrib><creatorcontrib>te Velde, Egbert R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van Kooij, Roelof J.</au><au>Looman, Caspar W.N.</au><au>Habbema, Johannes D.F.</au><au>Dorland, Marinus</au><au>te Velde, Egbert R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age-dependent decrease in embryo implantation rate after in vitro fertilization</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>66</volume><issue>5</issue><spage>769</spage><epage>775</epage><pages>769-775</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>To investigate the relation between the implantation rate per embryo after replacement in IVF-ET in relation to female age.
Retrospective study using linear and biphasic models in a multivariate analysis.
Academic tertiary care institution.
In vitro fertilization-ET and determination of gestational sacs at 6 to 7 weeks of pregnancy by ultrasound.
Implantation rate as defined by the number of gestational sacs per embryo replaced.
Woman’s age and embryo morphology were strongly related to the implantation rate; indication for IVF-ET and cycle rank number also were related significantly but less strongly. A linear model was built describing the decrease in implantation rate with age, resulting in a decrease of approximately 7%. A biphasic model was tested also and performed significantly better, resulting in a yearly decrease of >20% after 37 years of age.
The most important independent factors related to the ability of embryos to implant are female age and embryo morphology. The best way to describe the relation with female age is a biphasic model with a discontinuity at approximately 37 years of age.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8893683</pmid><doi>10.1016/S0015-0282(16)58634-8</doi><tpages>7</tpages></addata></record> |
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| ispartof | Fertility and sterility, 1996-11, Vol.66 (5), p.769-775 |
| issn | 0015-0282 1556-5653 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via ScienceDirect (Elsevier); Alma/SFX Local Collection |
| subjects | Aging Biological and medical sciences Birth control Embryo Implantation - physiology embryo morphology Embryo Transfer Female female age Fertilization in Vitro Gynecology. Andrology. Obstetrics Humans Implantation rate in vitro fertilization Infertility - etiology Infertility - therapy Male Medical sciences Multivariate Analysis Pregnancy Sterility. Assisted procreation |
| title | Age-dependent decrease in embryo implantation rate after in vitro fertilization |
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