Enantioselective inhibition of the formalin paw late phase by the NK1 receptor antagonist L-733,060 in gerbils

Intravenous administration of the NK1 receptor antagonist l-733,060 to gerbils 3 h before intraplantar injection of formalin caused a dose-dependent and complete inhibition of the late, but not the early, phase nociceptive response (paw licking). The ID50 for l-733,060 (0.17 mg/kg) revealed a greate...

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