PC-2, linear homoglucan with α-linkages, peripherally enhances the hippocampal long-term potentiation
To investigate central effectiveness of PC-2, a glucan from lichen Parmelia caperata with alpha(1-3)(1-4) linkages in the ratio 3:2, with regard to the long-term potentiation (LTP) of evoked potential. The extent of LTP, induced by high-frequency stimulation of medial perforant pathway, was evaluate...
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| Veröffentlicht in: | Pharmaceutical research 1996-09, Vol.13 (9), p.1322-1326 |
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| creator | SMRIGA, M SAITO, H SHIBATA, S NARUI, T OKUYAMA, T NISHIYAMA, N |
| description | To investigate central effectiveness of PC-2, a glucan from lichen Parmelia caperata with alpha(1-3)(1-4) linkages in the ratio 3:2, with regard to the long-term potentiation (LTP) of evoked potential.
The extent of LTP, induced by high-frequency stimulation of medial perforant pathway, was evaluated as fractional increase in population spike amplitude in dentate gyrus in anesthetized rats.
Oral and intravenous application of PC-2 resulted in significant enhancement of LTP elicited by a weak, but not by a strong, tetanic stimulation. No influence of PC-2 on basal evoked synaptic potential was found. Bilateral adrenalectomy profoundly suppressed the positive impact of the glucan on the formation of LTP, but showed no effect upon the magnitude and time-course of population spike enhancement in vehicle-treated subjects. Two related alpha-glucans with different chemical structures did not show any effect comparable to that of PC-2.
Peripheral application of PC-2 significantly enhances LTP in dentate gyrus in rats. Results indicate that the effect of PC-2 might be peripherally mediated and that the specific higher structure of PC-2 is crucial for its biological activity. |
| doi_str_mv | 10.1023/A:1016009630329 |
| format | Article |
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The extent of LTP, induced by high-frequency stimulation of medial perforant pathway, was evaluated as fractional increase in population spike amplitude in dentate gyrus in anesthetized rats.
Oral and intravenous application of PC-2 resulted in significant enhancement of LTP elicited by a weak, but not by a strong, tetanic stimulation. No influence of PC-2 on basal evoked synaptic potential was found. Bilateral adrenalectomy profoundly suppressed the positive impact of the glucan on the formation of LTP, but showed no effect upon the magnitude and time-course of population spike enhancement in vehicle-treated subjects. Two related alpha-glucans with different chemical structures did not show any effect comparable to that of PC-2.
Peripheral application of PC-2 significantly enhances LTP in dentate gyrus in rats. Results indicate that the effect of PC-2 might be peripherally mediated and that the specific higher structure of PC-2 is crucial for its biological activity.</description><identifier>ISSN: 0724-8741</identifier><identifier>EISSN: 1573-904X</identifier><identifier>DOI: 10.1023/A:1016009630329</identifier><identifier>PMID: 8893269</identifier><identifier>CODEN: PHREEB</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Adrenalectomy ; Animals ; Biological and medical sciences ; Carbohydrate Sequence ; Dentate Gyrus - drug effects ; Dentate Gyrus - physiology ; Evoked Potentials ; Glucans - isolation & purification ; Glucans - pharmacology ; Lichens - chemistry ; Long-Term Potentiation - drug effects ; Male ; Medical sciences ; Molecular Sequence Data ; Neuropharmacology ; Pharmacology. Drug treatments ; Polysaccharides - administration & dosage ; Polysaccharides - isolation & purification ; Polysaccharides - pharmacology ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Rats ; Rats, Wistar</subject><ispartof>Pharmaceutical research, 1996-09, Vol.13 (9), p.1322-1326</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c281t-f7a9cfdb226dd6199c15a62432e074fe6286fd27333925a348224c82a392ce0e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3232822$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8893269$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SMRIGA, M</creatorcontrib><creatorcontrib>SAITO, H</creatorcontrib><creatorcontrib>SHIBATA, S</creatorcontrib><creatorcontrib>NARUI, T</creatorcontrib><creatorcontrib>OKUYAMA, T</creatorcontrib><creatorcontrib>NISHIYAMA, N</creatorcontrib><title>PC-2, linear homoglucan with α-linkages, peripherally enhances the hippocampal long-term potentiation</title><title>Pharmaceutical research</title><addtitle>Pharm Res</addtitle><description>To investigate central effectiveness of PC-2, a glucan from lichen Parmelia caperata with alpha(1-3)(1-4) linkages in the ratio 3:2, with regard to the long-term potentiation (LTP) of evoked potential.
The extent of LTP, induced by high-frequency stimulation of medial perforant pathway, was evaluated as fractional increase in population spike amplitude in dentate gyrus in anesthetized rats.
Oral and intravenous application of PC-2 resulted in significant enhancement of LTP elicited by a weak, but not by a strong, tetanic stimulation. No influence of PC-2 on basal evoked synaptic potential was found. Bilateral adrenalectomy profoundly suppressed the positive impact of the glucan on the formation of LTP, but showed no effect upon the magnitude and time-course of population spike enhancement in vehicle-treated subjects. Two related alpha-glucans with different chemical structures did not show any effect comparable to that of PC-2.
Peripheral application of PC-2 significantly enhances LTP in dentate gyrus in rats. Results indicate that the effect of PC-2 might be peripherally mediated and that the specific higher structure of PC-2 is crucial for its biological activity.</description><subject>Adrenalectomy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carbohydrate Sequence</subject><subject>Dentate Gyrus - drug effects</subject><subject>Dentate Gyrus - physiology</subject><subject>Evoked Potentials</subject><subject>Glucans - isolation & purification</subject><subject>Glucans - pharmacology</subject><subject>Lichens - chemistry</subject><subject>Long-Term Potentiation - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Polysaccharides - administration & dosage</subject><subject>Polysaccharides - isolation & purification</subject><subject>Polysaccharides - pharmacology</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0724-8741</issn><issn>1573-904X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LxDAQhoMouq6ePQk5iCerySRtE2_L4hcIelDwVsZ0uo2mHzZdxJ_lH_E3WXDxNLw8D_Myw9iRFOdSgLpYXEohMyFspoQCu8VmMs1VYoV-2WYzkYNOTK7lHtuP8U0IYaTVu2zXGKsgszNWPS4TOOPBt4QDr7umW4W1w5Z_-rHmP9_JRN5xRfGM9zT4vqYBQ_ji1NbYOop8rInXvu87h02PgYeuXSUjDQ3vu5Ha0ePou_aA7VQYIh1u5pw9X189LW-T-4ebu-XiPnFg5JhUOVpXla8AWVlm0lonU8xAKyCR64oyMFlVQq6UspCi0gZAOwM4RUeC1Jyd_u3th-5jTXEsGh8dhYAtdetY5EabNBVyEo834vq1obLoB9_g8FVsHjPxkw3H6DBUw3Stj_-aAgVTt_oFB-NyrA</recordid><startdate>19960901</startdate><enddate>19960901</enddate><creator>SMRIGA, M</creator><creator>SAITO, H</creator><creator>SHIBATA, S</creator><creator>NARUI, T</creator><creator>OKUYAMA, T</creator><creator>NISHIYAMA, N</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19960901</creationdate><title>PC-2, linear homoglucan with α-linkages, peripherally enhances the hippocampal long-term potentiation</title><author>SMRIGA, M ; SAITO, H ; SHIBATA, S ; NARUI, T ; OKUYAMA, T ; NISHIYAMA, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-f7a9cfdb226dd6199c15a62432e074fe6286fd27333925a348224c82a392ce0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adrenalectomy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carbohydrate Sequence</topic><topic>Dentate Gyrus - drug effects</topic><topic>Dentate Gyrus - physiology</topic><topic>Evoked Potentials</topic><topic>Glucans - isolation & purification</topic><topic>Glucans - pharmacology</topic><topic>Lichens - chemistry</topic><topic>Long-Term Potentiation - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Polysaccharides - administration & dosage</topic><topic>Polysaccharides - isolation & purification</topic><topic>Polysaccharides - pharmacology</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SMRIGA, M</creatorcontrib><creatorcontrib>SAITO, H</creatorcontrib><creatorcontrib>SHIBATA, S</creatorcontrib><creatorcontrib>NARUI, T</creatorcontrib><creatorcontrib>OKUYAMA, T</creatorcontrib><creatorcontrib>NISHIYAMA, N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmaceutical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SMRIGA, M</au><au>SAITO, H</au><au>SHIBATA, S</au><au>NARUI, T</au><au>OKUYAMA, T</au><au>NISHIYAMA, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PC-2, linear homoglucan with α-linkages, peripherally enhances the hippocampal long-term potentiation</atitle><jtitle>Pharmaceutical research</jtitle><addtitle>Pharm Res</addtitle><date>1996-09-01</date><risdate>1996</risdate><volume>13</volume><issue>9</issue><spage>1322</spage><epage>1326</epage><pages>1322-1326</pages><issn>0724-8741</issn><eissn>1573-904X</eissn><coden>PHREEB</coden><abstract>To investigate central effectiveness of PC-2, a glucan from lichen Parmelia caperata with alpha(1-3)(1-4) linkages in the ratio 3:2, with regard to the long-term potentiation (LTP) of evoked potential.
The extent of LTP, induced by high-frequency stimulation of medial perforant pathway, was evaluated as fractional increase in population spike amplitude in dentate gyrus in anesthetized rats.
Oral and intravenous application of PC-2 resulted in significant enhancement of LTP elicited by a weak, but not by a strong, tetanic stimulation. No influence of PC-2 on basal evoked synaptic potential was found. Bilateral adrenalectomy profoundly suppressed the positive impact of the glucan on the formation of LTP, but showed no effect upon the magnitude and time-course of population spike enhancement in vehicle-treated subjects. Two related alpha-glucans with different chemical structures did not show any effect comparable to that of PC-2.
Peripheral application of PC-2 significantly enhances LTP in dentate gyrus in rats. Results indicate that the effect of PC-2 might be peripherally mediated and that the specific higher structure of PC-2 is crucial for its biological activity.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>8893269</pmid><doi>10.1023/A:1016009630329</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adrenalectomy Animals Biological and medical sciences Carbohydrate Sequence Dentate Gyrus - drug effects Dentate Gyrus - physiology Evoked Potentials Glucans - isolation & purification Glucans - pharmacology Lichens - chemistry Long-Term Potentiation - drug effects Male Medical sciences Molecular Sequence Data Neuropharmacology Pharmacology. Drug treatments Polysaccharides - administration & dosage Polysaccharides - isolation & purification Polysaccharides - pharmacology Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Wistar |
| title | PC-2, linear homoglucan with α-linkages, peripherally enhances the hippocampal long-term potentiation |
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