Analysis of prognostic variables and results after vertical partial laryngectomy
A consecutive series of 197 patients who underwent conservation surgery for squamous cell carcinoma of the glottic larynx was analyzed. The majority of patients were male. One hundred forty-one had stage I disease, 44 had stage II, and 12 had stage III disease at the time of treatment. Partial laryn...
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| Veröffentlicht in: | The American journal of surgery 1988-10, Vol.156 (4), p.264-268 |
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| container_title | The American journal of surgery |
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| creator | Chee Soo, Khee Shah, Jatin P. Gopinath, Kodaganur S. Jaques, David P. Gerold, Frank P. Strong, Elliot W. |
| description | A consecutive series of 197 patients who underwent conservation surgery for squamous cell carcinoma of the glottic larynx was analyzed. The majority of patients were male. One hundred forty-one had stage I disease, 44 had stage II, and 12 had stage III disease at the time of treatment. Partial laryngectomy was performed in 25 patients who had recurrent cancer after previous definitive radiotherapy and in 5 patients who had previously undergone cordectomy. There was no operative mortality and postoperative morbidity was low. Local recurrence developed in 32 patients (17 percent); cervical metastasis developed in 8 patients. The determinate survival rates at 3 and 5 years were 92 percent and 87 percent, respectively. Multivariate analysis showed soft-tissue margins and tumor differentiation as the two sigificant covariates in predicting survival. Positive surgical margins were also significant covariates affecting local recurrence. These data suggest that conservation surgery is an effective treatment for early vocal cord carcinoma. Adequate surgical margins are essential. Postoperative irradiation should be considered in patients with inadequate margins. |
| doi_str_mv | 10.1016/S0002-9610(88)80288-5 |
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The majority of patients were male. One hundred forty-one had stage I disease, 44 had stage II, and 12 had stage III disease at the time of treatment. Partial laryngectomy was performed in 25 patients who had recurrent cancer after previous definitive radiotherapy and in 5 patients who had previously undergone cordectomy. There was no operative mortality and postoperative morbidity was low. Local recurrence developed in 32 patients (17 percent); cervical metastasis developed in 8 patients. The determinate survival rates at 3 and 5 years were 92 percent and 87 percent, respectively. Multivariate analysis showed soft-tissue margins and tumor differentiation as the two sigificant covariates in predicting survival. Positive surgical margins were also significant covariates affecting local recurrence. These data suggest that conservation surgery is an effective treatment for early vocal cord carcinoma. Adequate surgical margins are essential. Postoperative irradiation should be considered in patients with inadequate margins.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/S0002-9610(88)80288-5</identifier><identifier>PMID: 3177747</identifier><identifier>CODEN: AJSUAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma - mortality ; Carcinoma - surgery ; Female ; Follow-Up Studies ; Glottis - surgery ; Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics ; Humans ; Laryngeal Neoplasms - mortality ; Laryngeal Neoplasms - surgery ; Laryngectomy - methods ; Laryngectomy - mortality ; Male ; Medical sciences ; Middle Aged ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - surgery ; Prognosis ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the upper aerodigestive tract</subject><ispartof>The American journal of surgery, 1988-10, Vol.156 (4), p.264-268</ispartof><rights>1988 Reed Publishing USA</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-4d8a33b0ec56b52aa9e9a2e224688baa72c61e46eaeb2be73d5c3d708eb9f4b03</citedby><cites>FETCH-LOGICAL-c389t-4d8a33b0ec56b52aa9e9a2e224688baa72c61e46eaeb2be73d5c3d708eb9f4b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0002-9610(88)80288-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,780,784,789,790,3548,23929,23930,25139,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7064521$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3177747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chee Soo, Khee</creatorcontrib><creatorcontrib>Shah, Jatin P.</creatorcontrib><creatorcontrib>Gopinath, Kodaganur S.</creatorcontrib><creatorcontrib>Jaques, David P.</creatorcontrib><creatorcontrib>Gerold, Frank P.</creatorcontrib><creatorcontrib>Strong, Elliot W.</creatorcontrib><title>Analysis of prognostic variables and results after vertical partial laryngectomy</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>A consecutive series of 197 patients who underwent conservation surgery for squamous cell carcinoma of the glottic larynx was analyzed. The majority of patients were male. One hundred forty-one had stage I disease, 44 had stage II, and 12 had stage III disease at the time of treatment. Partial laryngectomy was performed in 25 patients who had recurrent cancer after previous definitive radiotherapy and in 5 patients who had previously undergone cordectomy. There was no operative mortality and postoperative morbidity was low. Local recurrence developed in 32 patients (17 percent); cervical metastasis developed in 8 patients. The determinate survival rates at 3 and 5 years were 92 percent and 87 percent, respectively. Multivariate analysis showed soft-tissue margins and tumor differentiation as the two sigificant covariates in predicting survival. Positive surgical margins were also significant covariates affecting local recurrence. These data suggest that conservation surgery is an effective treatment for early vocal cord carcinoma. Adequate surgical margins are essential. Postoperative irradiation should be considered in patients with inadequate margins.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma - mortality</subject><subject>Carcinoma - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glottis - surgery</subject><subject>Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics</subject><subject>Humans</subject><subject>Laryngeal Neoplasms - mortality</subject><subject>Laryngeal Neoplasms - surgery</subject><subject>Laryngectomy - methods</subject><subject>Laryngectomy - mortality</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Prognosis</subject><subject>Surgery (general aspects). 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Graft diseases</subject><subject>Surgery of the upper aerodigestive tract</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LxDAQhoMoun78BKEHET1U89E205OI-AWCgnoOk3QqkW67Jt2F_fdm3WWvnmbCPJN5eRg7FfxKcFFdv3POZV5Xgl8AXAKXAHm5wyYCdJ0LALXLJlvkgB3G-J2eQhRqn-0robUu9IS93fbYLaOP2dBmszB89UMcvcsWGDzajmKGfZMFivNuTH07UsgWFBKCXTbD1KTaYVj2X-TGYbo8ZnstdpFONvWIfT7cf9w95S-vj893ty-5U1CPedEAKmU5ubKypUSsqUZJUhYVgEXU0lWCioqQrLSkVVM61WgOZOu2sFwdsfP1vyn0z5ziaKY-Ouo67GmYR6OhgFLpMoHlGnRhiDFQa2bBT1NiI7hZmTR_Js1KkwEwfybNau90c2Bup9Rstzbq0vxsM8eYZLQBe-fjFtO8KkopEnazxijJWHgKJjpPvaPGh2TMNIP_J8gvO0yRfw</recordid><startdate>19881001</startdate><enddate>19881001</enddate><creator>Chee Soo, Khee</creator><creator>Shah, Jatin P.</creator><creator>Gopinath, Kodaganur S.</creator><creator>Jaques, David P.</creator><creator>Gerold, Frank P.</creator><creator>Strong, Elliot W.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19881001</creationdate><title>Analysis of prognostic variables and results after vertical partial laryngectomy</title><author>Chee Soo, Khee ; Shah, Jatin P. ; Gopinath, Kodaganur S. ; Jaques, David P. ; Gerold, Frank P. ; Strong, Elliot W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-4d8a33b0ec56b52aa9e9a2e224688baa72c61e46eaeb2be73d5c3d708eb9f4b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma - mortality</topic><topic>Carcinoma - surgery</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glottis - surgery</topic><topic>Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics</topic><topic>Humans</topic><topic>Laryngeal Neoplasms - mortality</topic><topic>Laryngeal Neoplasms - surgery</topic><topic>Laryngectomy - methods</topic><topic>Laryngectomy - mortality</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>Prognosis</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the upper aerodigestive tract</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chee Soo, Khee</creatorcontrib><creatorcontrib>Shah, Jatin P.</creatorcontrib><creatorcontrib>Gopinath, Kodaganur S.</creatorcontrib><creatorcontrib>Jaques, David P.</creatorcontrib><creatorcontrib>Gerold, Frank P.</creatorcontrib><creatorcontrib>Strong, Elliot W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chee Soo, Khee</au><au>Shah, Jatin P.</au><au>Gopinath, Kodaganur S.</au><au>Jaques, David P.</au><au>Gerold, Frank P.</au><au>Strong, Elliot W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of prognostic variables and results after vertical partial laryngectomy</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>1988-10-01</date><risdate>1988</risdate><volume>156</volume><issue>4</issue><spage>264</spage><epage>268</epage><pages>264-268</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><coden>AJSUAB</coden><abstract>A consecutive series of 197 patients who underwent conservation surgery for squamous cell carcinoma of the glottic larynx was analyzed. The majority of patients were male. One hundred forty-one had stage I disease, 44 had stage II, and 12 had stage III disease at the time of treatment. Partial laryngectomy was performed in 25 patients who had recurrent cancer after previous definitive radiotherapy and in 5 patients who had previously undergone cordectomy. There was no operative mortality and postoperative morbidity was low. Local recurrence developed in 32 patients (17 percent); cervical metastasis developed in 8 patients. The determinate survival rates at 3 and 5 years were 92 percent and 87 percent, respectively. Multivariate analysis showed soft-tissue margins and tumor differentiation as the two sigificant covariates in predicting survival. Positive surgical margins were also significant covariates affecting local recurrence. These data suggest that conservation surgery is an effective treatment for early vocal cord carcinoma. Adequate surgical margins are essential. Postoperative irradiation should be considered in patients with inadequate margins.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3177747</pmid><doi>10.1016/S0002-9610(88)80288-5</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma - mortality Carcinoma - surgery Female Follow-Up Studies Glottis - surgery Head and neck surgery. Maxillofacial surgery. Dental surgery. Orthodontics Humans Laryngeal Neoplasms - mortality Laryngeal Neoplasms - surgery Laryngectomy - methods Laryngectomy - mortality Male Medical sciences Middle Aged Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - surgery Prognosis Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the upper aerodigestive tract |
| title | Analysis of prognostic variables and results after vertical partial laryngectomy |
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