Induction and its spread of apoptosis in rat spinal cord after mechanical trauma
This study was undertaken to examine the spinal cord of rats after trauma for the induction of apoptosis. DNA ladder formation was demonstrated by gel electrophoresis of the DNA obtained from the spinal cord at the site of injury after trauma from 12 h to 8 days and was most significant on Days 3 an...
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| Veröffentlicht in: | Neuroscience letters 1996-09, Vol.216 (1), p.9-12 |
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| container_title | Neuroscience letters |
| container_volume | 216 |
| creator | Katoh, Kenji Ikata, Takaaki Katoh, Shinsuke Hamada, Yoshitaka Nakauchi, Kenji Sano, Toshiaki Niwa, Mineo |
| description | This study was undertaken to examine the spinal cord of rats after trauma for the induction of apoptosis. DNA ladder formation was demonstrated by gel electrophoresis of the DNA obtained from the spinal cord at the site of injury after trauma from 12 h to 8 days and was most significant on Days 3 and 4. As for the longitudinal spread of the injury in the spinal cord, the ladder formation was observed in the two segments adjacent to the site of trauma 3 days after trauma. Histological examination using in situ end labeling also demonstrated the appearance of apoptosis. These results provide the evidence for the induction of apoptosis in the spinal cord after trauma in rats. |
| doi_str_mv | 10.1016/0304-3940(96)12999-2 |
| format | Article |
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DNA ladder formation was demonstrated by gel electrophoresis of the DNA obtained from the spinal cord at the site of injury after trauma from 12 h to 8 days and was most significant on Days 3 and 4. As for the longitudinal spread of the injury in the spinal cord, the ladder formation was observed in the two segments adjacent to the site of trauma 3 days after trauma. Histological examination using in situ end labeling also demonstrated the appearance of apoptosis. These results provide the evidence for the induction of apoptosis in the spinal cord after trauma in rats.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(96)12999-2</identifier><identifier>PMID: 8892379</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Apoptosis ; Apoptosis - physiology ; Biological and medical sciences ; DNA Fragmentation - physiology ; DNA ladder formation ; Electrophoresis, Polyacrylamide Gel ; Histocytochemistry ; In situ end labeling ; Injuries of the nervous system and the skull. Diseases due to physical agents ; Male ; Medical sciences ; Rats ; Rats, Wistar ; Spinal Cord Injuries - metabolism ; Spinal Cord Injuries - pathology ; Spinal cord injury ; Traumas. Diseases due to physical agents</subject><ispartof>Neuroscience letters, 1996-09, Vol.216 (1), p.9-12</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-2b313e65ae78337045a9df377aca3f5817cc97d3b3ff59bf41fd16514a66998f3</citedby><cites>FETCH-LOGICAL-c386t-2b313e65ae78337045a9df377aca3f5817cc97d3b3ff59bf41fd16514a66998f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3940(96)12999-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3229404$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8892379$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katoh, Kenji</creatorcontrib><creatorcontrib>Ikata, Takaaki</creatorcontrib><creatorcontrib>Katoh, Shinsuke</creatorcontrib><creatorcontrib>Hamada, Yoshitaka</creatorcontrib><creatorcontrib>Nakauchi, Kenji</creatorcontrib><creatorcontrib>Sano, Toshiaki</creatorcontrib><creatorcontrib>Niwa, Mineo</creatorcontrib><title>Induction and its spread of apoptosis in rat spinal cord after mechanical trauma</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>This study was undertaken to examine the spinal cord of rats after trauma for the induction of apoptosis. DNA ladder formation was demonstrated by gel electrophoresis of the DNA obtained from the spinal cord at the site of injury after trauma from 12 h to 8 days and was most significant on Days 3 and 4. As for the longitudinal spread of the injury in the spinal cord, the ladder formation was observed in the two segments adjacent to the site of trauma 3 days after trauma. Histological examination using in situ end labeling also demonstrated the appearance of apoptosis. These results provide the evidence for the induction of apoptosis in the spinal cord after trauma in rats.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - physiology</subject><subject>Biological and medical sciences</subject><subject>DNA Fragmentation - physiology</subject><subject>DNA ladder formation</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Histocytochemistry</subject><subject>In situ end labeling</subject><subject>Injuries of the nervous system and the skull. Diseases due to physical agents</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Spinal Cord Injuries - metabolism</subject><subject>Spinal Cord Injuries - pathology</subject><subject>Spinal cord injury</subject><subject>Traumas. Diseases due to physical agents</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtqHDEQRUWwccZO_iABLUKwF23r1S1pYwjGLzA4i2QtavTAMtNSR1IH8vfuyQyz9Eqge-qqdBD6QsklJXS4IpyIjmtBzvVwQZnWumMf0IoqyTqpJTtCqwPyEZ3W-koI6WkvTtCJUppxqVfo52Nys20xJwzJ4dgqrlPx4HAOGKY8tVxjxTHhAm2JYoINtrk4DKH5gkdvXyBFu9y2AvMIn9BxgE31n_fnGfp9d_vr5qF7er5_vPnx1FmuhtaxNafcDz14qTiXRPSgXeBSggUeekWltVo6vuYh9HodBA2ODj0VMAxaq8DP0Pdd71Tyn9nXZsZYrd9sIPk8VyOVUD1RYgHFDrQl11p8MFOJI5R_hhKzFWm2lszWktGD-S_SsGXs675_Xo_eHYb25pb82z6Huvw-FEg21gPGGVsKt69f7zC_uPgbfTHVRp-sd7F424zL8f093gD2u46N</recordid><startdate>19960920</startdate><enddate>19960920</enddate><creator>Katoh, Kenji</creator><creator>Ikata, Takaaki</creator><creator>Katoh, Shinsuke</creator><creator>Hamada, Yoshitaka</creator><creator>Nakauchi, Kenji</creator><creator>Sano, Toshiaki</creator><creator>Niwa, Mineo</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19960920</creationdate><title>Induction and its spread of apoptosis in rat spinal cord after mechanical trauma</title><author>Katoh, Kenji ; Ikata, Takaaki ; Katoh, Shinsuke ; Hamada, Yoshitaka ; Nakauchi, Kenji ; Sano, Toshiaki ; Niwa, Mineo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-2b313e65ae78337045a9df377aca3f5817cc97d3b3ff59bf41fd16514a66998f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - physiology</topic><topic>Biological and medical sciences</topic><topic>DNA Fragmentation - physiology</topic><topic>DNA ladder formation</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Histocytochemistry</topic><topic>In situ end labeling</topic><topic>Injuries of the nervous system and the skull. Diseases due to physical agents</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Spinal Cord Injuries - metabolism</topic><topic>Spinal Cord Injuries - pathology</topic><topic>Spinal cord injury</topic><topic>Traumas. Diseases due to physical agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Katoh, Kenji</creatorcontrib><creatorcontrib>Ikata, Takaaki</creatorcontrib><creatorcontrib>Katoh, Shinsuke</creatorcontrib><creatorcontrib>Hamada, Yoshitaka</creatorcontrib><creatorcontrib>Nakauchi, Kenji</creatorcontrib><creatorcontrib>Sano, Toshiaki</creatorcontrib><creatorcontrib>Niwa, Mineo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katoh, Kenji</au><au>Ikata, Takaaki</au><au>Katoh, Shinsuke</au><au>Hamada, Yoshitaka</au><au>Nakauchi, Kenji</au><au>Sano, Toshiaki</au><au>Niwa, Mineo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction and its spread of apoptosis in rat spinal cord after mechanical trauma</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1996-09-20</date><risdate>1996</risdate><volume>216</volume><issue>1</issue><spage>9</spage><epage>12</epage><pages>9-12</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>This study was undertaken to examine the spinal cord of rats after trauma for the induction of apoptosis. DNA ladder formation was demonstrated by gel electrophoresis of the DNA obtained from the spinal cord at the site of injury after trauma from 12 h to 8 days and was most significant on Days 3 and 4. As for the longitudinal spread of the injury in the spinal cord, the ladder formation was observed in the two segments adjacent to the site of trauma 3 days after trauma. Histological examination using in situ end labeling also demonstrated the appearance of apoptosis. These results provide the evidence for the induction of apoptosis in the spinal cord after trauma in rats.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>8892379</pmid><doi>10.1016/0304-3940(96)12999-2</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1996-09, Vol.216 (1), p.9-12 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Apoptosis Apoptosis - physiology Biological and medical sciences DNA Fragmentation - physiology DNA ladder formation Electrophoresis, Polyacrylamide Gel Histocytochemistry In situ end labeling Injuries of the nervous system and the skull. Diseases due to physical agents Male Medical sciences Rats Rats, Wistar Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology Spinal cord injury Traumas. Diseases due to physical agents |
| title | Induction and its spread of apoptosis in rat spinal cord after mechanical trauma |
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