Suppression of adjuvant arthritis by κ-opioid receptor agonist : Effect of route of administration and strain differences
It is well established that kappa-opioid receptor agonists exert antiinflammatory and antihyperalgesic effects during nonspecific inflammation as well as suppressive effects on the development of humoral and cell-mediated immune responses to foreign antigens. The aim of this study was to investigate...
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Veröffentlicht in: | Immunopharmacology 1996-09, Vol.34 (2-3), p.105-112 |
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creator | ANTIC, J VASILJEVIC, T STANOJEVIC, S VUJIC, V KOVACEVIC-JOVANOVIC, V DJERGOVIC, D MILJEVIC, C MARKOVIC, B. M RADULOVIC, J |
description | It is well established that kappa-opioid receptor agonists exert antiinflammatory and antihyperalgesic effects during nonspecific inflammation as well as suppressive effects on the development of humoral and cell-mediated immune responses to foreign antigens. The aim of this study was to investigate the ability of the kappa-opioid receptor agonist MR 2034 to modulate adjuvant arthritis in the rat. In the first series of experiments, treatments of Wistar rats were performed using several routes of drug administration: intraperitoneal (ip), intracaudal (ic), intracerebroventricular (icv) and intraplantar (ipl). MR 2034 significantly suppressed joint swelling after ip and ic treatment, slightly reduced inflammation after ipl treatment, and did not produce any effect after icv treatment. In the second series of experiments, the suppressive effect of ip injected MR 2034 was investigated using Wistar, Dark August (DA) and Lewis rats. In Wistar rats, MR 2034 significantly decreased the incidence of adjuvant arthritis, and suppressed mean joint score and aggregate joint score. Similarly, in DA rats treated with MR 2034, mean arthritic score was significantly suppressed, but other clinical parameters were not affected. In Lewis rats, however, ip treatment with MR 2034 failed to produce any suppressive effect on joint disease and even potentiated the initial development of arthritis. These data suggest that immunosuppressive and antiinflammatory action of MR 2034 markedly depend on the route of drug administration and strain susceptibility to opioids. |
doi_str_mv | 10.1016/0162-3109(96)00114-2 |
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M ; RADULOVIC, J</creator><creatorcontrib>ANTIC, J ; VASILJEVIC, T ; STANOJEVIC, S ; VUJIC, V ; KOVACEVIC-JOVANOVIC, V ; DJERGOVIC, D ; MILJEVIC, C ; MARKOVIC, B. M ; RADULOVIC, J</creatorcontrib><description>It is well established that kappa-opioid receptor agonists exert antiinflammatory and antihyperalgesic effects during nonspecific inflammation as well as suppressive effects on the development of humoral and cell-mediated immune responses to foreign antigens. The aim of this study was to investigate the ability of the kappa-opioid receptor agonist MR 2034 to modulate adjuvant arthritis in the rat. In the first series of experiments, treatments of Wistar rats were performed using several routes of drug administration: intraperitoneal (ip), intracaudal (ic), intracerebroventricular (icv) and intraplantar (ipl). MR 2034 significantly suppressed joint swelling after ip and ic treatment, slightly reduced inflammation after ipl treatment, and did not produce any effect after icv treatment. In the second series of experiments, the suppressive effect of ip injected MR 2034 was investigated using Wistar, Dark August (DA) and Lewis rats. In Wistar rats, MR 2034 significantly decreased the incidence of adjuvant arthritis, and suppressed mean joint score and aggregate joint score. Similarly, in DA rats treated with MR 2034, mean arthritic score was significantly suppressed, but other clinical parameters were not affected. In Lewis rats, however, ip treatment with MR 2034 failed to produce any suppressive effect on joint disease and even potentiated the initial development of arthritis. These data suggest that immunosuppressive and antiinflammatory action of MR 2034 markedly depend on the route of drug administration and strain susceptibility to opioids.</description><identifier>ISSN: 0162-3109</identifier><identifier>DOI: 10.1016/0162-3109(96)00114-2</identifier><identifier>PMID: 8886854</identifier><identifier>CODEN: IMMUDP</identifier><language>eng</language><publisher>Amsterdam: Elsevier</publisher><subject>Animals ; Arthritis, Experimental - prevention & control ; Benzomorphans - administration & dosage ; Biological and medical sciences ; Immunomodulators ; Immunosuppressive Agents - administration & dosage ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Lew ; Rats, Wistar ; Receptors, Opioid, kappa - agonists ; Species Specificity</subject><ispartof>Immunopharmacology, 1996-09, Vol.34 (2-3), p.105-112</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3197974$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8886854$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ANTIC, J</creatorcontrib><creatorcontrib>VASILJEVIC, T</creatorcontrib><creatorcontrib>STANOJEVIC, S</creatorcontrib><creatorcontrib>VUJIC, V</creatorcontrib><creatorcontrib>KOVACEVIC-JOVANOVIC, V</creatorcontrib><creatorcontrib>DJERGOVIC, D</creatorcontrib><creatorcontrib>MILJEVIC, C</creatorcontrib><creatorcontrib>MARKOVIC, B. M</creatorcontrib><creatorcontrib>RADULOVIC, J</creatorcontrib><title>Suppression of adjuvant arthritis by κ-opioid receptor agonist : Effect of route of administration and strain differences</title><title>Immunopharmacology</title><addtitle>Immunopharmacology</addtitle><description>It is well established that kappa-opioid receptor agonists exert antiinflammatory and antihyperalgesic effects during nonspecific inflammation as well as suppressive effects on the development of humoral and cell-mediated immune responses to foreign antigens. The aim of this study was to investigate the ability of the kappa-opioid receptor agonist MR 2034 to modulate adjuvant arthritis in the rat. In the first series of experiments, treatments of Wistar rats were performed using several routes of drug administration: intraperitoneal (ip), intracaudal (ic), intracerebroventricular (icv) and intraplantar (ipl). MR 2034 significantly suppressed joint swelling after ip and ic treatment, slightly reduced inflammation after ipl treatment, and did not produce any effect after icv treatment. In the second series of experiments, the suppressive effect of ip injected MR 2034 was investigated using Wistar, Dark August (DA) and Lewis rats. In Wistar rats, MR 2034 significantly decreased the incidence of adjuvant arthritis, and suppressed mean joint score and aggregate joint score. Similarly, in DA rats treated with MR 2034, mean arthritic score was significantly suppressed, but other clinical parameters were not affected. In Lewis rats, however, ip treatment with MR 2034 failed to produce any suppressive effect on joint disease and even potentiated the initial development of arthritis. These data suggest that immunosuppressive and antiinflammatory action of MR 2034 markedly depend on the route of drug administration and strain susceptibility to opioids.</description><subject>Animals</subject><subject>Arthritis, Experimental - prevention & control</subject><subject>Benzomorphans - administration & dosage</subject><subject>Biological and medical sciences</subject><subject>Immunomodulators</subject><subject>Immunosuppressive Agents - administration & dosage</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. 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M</au><au>RADULOVIC, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppression of adjuvant arthritis by κ-opioid receptor agonist : Effect of route of administration and strain differences</atitle><jtitle>Immunopharmacology</jtitle><addtitle>Immunopharmacology</addtitle><date>1996-09-01</date><risdate>1996</risdate><volume>34</volume><issue>2-3</issue><spage>105</spage><epage>112</epage><pages>105-112</pages><issn>0162-3109</issn><coden>IMMUDP</coden><abstract>It is well established that kappa-opioid receptor agonists exert antiinflammatory and antihyperalgesic effects during nonspecific inflammation as well as suppressive effects on the development of humoral and cell-mediated immune responses to foreign antigens. The aim of this study was to investigate the ability of the kappa-opioid receptor agonist MR 2034 to modulate adjuvant arthritis in the rat. In the first series of experiments, treatments of Wistar rats were performed using several routes of drug administration: intraperitoneal (ip), intracaudal (ic), intracerebroventricular (icv) and intraplantar (ipl). MR 2034 significantly suppressed joint swelling after ip and ic treatment, slightly reduced inflammation after ipl treatment, and did not produce any effect after icv treatment. In the second series of experiments, the suppressive effect of ip injected MR 2034 was investigated using Wistar, Dark August (DA) and Lewis rats. In Wistar rats, MR 2034 significantly decreased the incidence of adjuvant arthritis, and suppressed mean joint score and aggregate joint score. Similarly, in DA rats treated with MR 2034, mean arthritic score was significantly suppressed, but other clinical parameters were not affected. In Lewis rats, however, ip treatment with MR 2034 failed to produce any suppressive effect on joint disease and even potentiated the initial development of arthritis. These data suggest that immunosuppressive and antiinflammatory action of MR 2034 markedly depend on the route of drug administration and strain susceptibility to opioids.</abstract><cop>Amsterdam</cop><pub>Elsevier</pub><pmid>8886854</pmid><doi>10.1016/0162-3109(96)00114-2</doi><tpages>8</tpages></addata></record> |
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subjects | Animals Arthritis, Experimental - prevention & control Benzomorphans - administration & dosage Biological and medical sciences Immunomodulators Immunosuppressive Agents - administration & dosage Male Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred Lew Rats, Wistar Receptors, Opioid, kappa - agonists Species Specificity |
title | Suppression of adjuvant arthritis by κ-opioid receptor agonist : Effect of route of administration and strain differences |
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