Ex vivo inhibition of rat brain cytochrome P-450 activity by stiripentol

Stiripentol is an anti-epileptic drug of novel structure with previously demonstrated strong in vitro inhibitory activity on rat cerebral cytochrome P-450 mediated naphthalene hydroxylation [6]. When administered to rats as a single i.p. dose, the drug is presently shown to have the same in vitro ef...

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Veröffentlicht in:	Biochemical pharmacology 1988-10, Vol.37 (19), p.3619-3622
Hauptverfasser:	Mesnil, Marcel, Testa, Bernard, Jenner, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Brain - enzymology Cytochrome P-450 Enzyme Inhibitors Dioxolanes - metabolism Dioxolanes - pharmacology Dioxoles - pharmacology Male Medical sciences Naphthalenes - metabolism Neuropharmacology Oxidation-Reduction Pharmacology. Drug treatments Rats Rats, Inbred Strains
Online-Zugang:	Volltext
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